FDA Approves Xeljanz (tofacitinib) for Pediatric Psoriatic Arthritis and Juvenile Idiopathic Arthritis
FDA approves Xeljanz for children with arthritis conditions.
The FDA approved Xeljanz (tofacitinib) for pediatric patients 2 years and older with active psoriatic arthritis or polyarticular course juve…
The FDA approved Xeljanz for children ages 2 and older with psoriatic arthritis or juvenile idiopathic arthritis. This provides a new oral o…
Nafamostat mesylate reduces bleeding risk compared to citrate for anticoagulation during continuous renal replacement therapy
Nafamostat mesylate may lower bleeding risks during kidney dialysis
This systematic review and meta-analysis of 2,247 CRRT patient episodes found that nafamostat mesylate significantly reduced the risk of ble…
A new analysis suggests nafamostat mesylate could be a safer alternative for patients at high risk of bleeding during continuous renal repla…
Belimumab linked to higher remission and low disease activity rates in SLE without glucocorticoids
Trial shows belimumab improves remission rates for lupus patients
A post hoc analysis of phase III trials found that belimumab plus standard therapy led to higher rates of DORIS remission and LLDAS attainme…
A new analysis of clinical trials shows that the drug belimumab helps more people with lupus reach specific remission goals compared to a pl…
Evaluating Treat to Target Outcomes in Elderly and Young Rheumatoid Arthritis Patients
Treat-to-Target Strategy Shows Promise for Elderly Rheumatoid Arthritis
A multicenter trial confirms that elderly patients achieve similar clinical outcomes and safety profiles as younger cohorts under a standard…
A new study shows that elderly patients with rheumatoid arthritis can achieve similar results to younger patients using a standard treat-to-…
Deucravacitinib modulates up to 2529 genes and SLE-relevant gene sets including interferon-regulated genes
Trial Shows Deucravacitinib Modulates Gene Activity in Lupus Patients
This post hoc analysis of a Phase 2 trial in 363 patients with systemic lupus erythematosus (SLE) found that deucravacitinib modulated up to…
A Phase 2 trial shows that deucravacitinib may influence specific gene sets and immune cell activity in people with systemic lupus erythemat…
Belimumab plus standard therapy shows numerically greater reductions in IgA, IgM, and anti-dsDNA antibodies
Trial Shows Belimumab May Help Manage Lupus Nephritis Symptoms
This Phase 3 randomized controlled trial of 446 adults with active lupus nephritis found that intravenous belimumab plus standard therapy re…
A Phase 3 trial identifies specific markers that may help predict how patients with lupus nephritis respond to belimumab treatment.
Upadacitinib 15 mg daily achieves DAS28-CRP ≤3.2 in 43.3% of patients versus 22.4% for adalimumab
Trial shows upadacitinib outperforms adalimumab for rheumatoid arthritis patients
This randomized controlled trial of 492 patients with rheumatoid arthritis and prior TNFi failure found upadacitinib 15 mg daily superior to…
A new trial finds that upadacitinib works better than adalimumab for people with rheumatoid arthritis who did not respond well to previous t…
Higher Triglyceride-Glucose index is associated with increased risk of albuminuria in chronic kidney disease
Higher Triglyceride-Glucose Index Linked to Kidney Damage Risk
This meta-analysis of cross-sectional and cohort studies involving 59,148 patients found that a higher TyG index is significantly associated…
A high triglyceride-glucose index may serve as an early warning sign for kidney issues, specifically a condition called albuminuria.
Corticosteroid and cyclophosphamide exposure are associated with higher mortality in Middle Eastern and North African SLE
Specific Medications Linked to Survival Rates in Lupus Patients
This meta-analysis of 3,478 adult patients in the MENA region found an all-cause mortality rate of 9.9% (95% CI: 7.2%-14.0%). While corticos…
New data identifies how specific medications and health conditions impact long-term survival for patients with systemic lupus erythematosus.
Spontaneous splenic rupture occurs as a rare but life-threatening complication in enteric fever infections
Typhoid and paratyphoid infections can cause rare splenic rupture
This case report and literature review examines spontaneous splenic rupture (SSR) in patients with typhoid and paratyphoid fever. The author…
A rare but life-threatening complication of enteric fever involves the spleen rupturing on its own, requiring doctors to stay alert during t…
Tai Chi and Wuqinxi reduce pain while Pilates and Baduanjin improve physical function in knee osteoarthritis
Tai Chi and Pilates May Improve Knee Osteoarthritis Symptoms
This network meta-analysis of 29 RCTs involving 2,095 participants found that specific mind-body exercises provide distinct benefits for kne…
Specific mind-body exercises like Tai Chi and Pilates may help manage pain and improve physical function for those with knee osteoarthritis.
Peer support may impact fear of disease progression and psychological symptoms in patients with glioma
Peer support may ease fear in glioma patients
This is a protocol for a systematic review and meta-analysis regarding the impact of peer support on fear of disease progression, fatigue, d…
A new meta-analysis protocol will examine whether peer support reduces fear of disease progression in glioma patients.