Narrative review explores mitochondrial-targeted therapeutics for oral squamous cell carcinoma
New drug strategy targets mouth cancer's hidden power source
This narrative review discusses the potential of mitochondrial-targeted therapeutics in oral squamous cell carcinoma (OSCC). The authors syn…
Targeting the cell's power source could help overcome stubborn mouth cancer resistance.
Meta-analysis shows AI virtual patient simulations improve psychiatric interview training in health professions education
AI Virtual Patients Boost Psychiatric Interview Skills
This meta-analysis synthesizes evidence from approximately 450 participants across 10 studies in health professions education. The authors r…
New AI tools help train doctors to talk better to patients with mental health issues by simulating real conversations.
Enpatoran fails to show dose-response in moderate-to-severe SLE phase 2 trial
New Lupus Drug Shows Promise But Misses Key Target in Trial
This phase 2 RCT enrolled 354 adults with moderate-to-severe SLE. Enpatoran (25, 50, or 100 mg twice daily) did not show a statistically sig…
A new daily pill for lupus called enpatoran helped more patients get relief from their symptoms, but the drug didn't hit the statistical tar…
Narrative review suggests MRgFUS reduces lesion size and symptoms in women with adenomyosis
Magnetic resonance-guided focused ultrasound surgery helps reduce lesion size and ease symptoms for women with adenomyosis
This narrative review examines magnetic resonance-guided focused ultrasound surgery (MRgFUS) for adenomyosis in women of childbearing age. T…
This review explains how magnetic resonance-guided focused ultrasound surgery can shrink problem areas and relieve pain for women with adeno…
Narrative review explores m6A modification and metabolic reprogramming in rheumatoid arthritis
Rheumatoid Arthritis May Start With a Tiny Chemical Tag on Your Genes
This narrative review examines the role of m6A modification in metabolic reprogramming during rheumatoid arthritis pathogenesis. The authors…
A hidden chemical switch in your cells may drive rheumatoid arthritis by turning on inflammation and joint damage.
Review of SC-EVs for SLE and MS highlights immunomodulatory mechanisms and neuroprotective potential
New cell-free therapy could calm immune fires in lupus and MS
This narrative review examines stem cell-derived extracellular vesicles (SC-EVs) for systemic lupus erythematosus and multiple sclerosis. Th…
Tiny cargo from stem cells might stop the immune system from attacking the brain and joints in lupus and MS patients
Review of rectal abscess case after endoscopic mucosal resection highlights diagnostic considerations
Rectal Surgery Complication Doctors Rarely See But Must Spot Fast
This narrative review discusses a case of rectal submucosal abscess following endoscopic mucosal resection for a rectal polyp in a 74-year-o…
A 74-year-old woman developed a dangerous hidden infection after standard polyp removal, proving why doctors must recognize rare complicatio…
Global research on olfactory dysfunction mechanisms shows rising publication trends and key molecular pathways
Smell Loss Signals Hidden Brain Changes Doctors Are Tracking Now
A comprehensive review of 7,915 articles reveals growing interest in olfactory dysfunction mechanisms linked to neurodegenerative diseases a…
• Smell trouble often warns of brain health issues early • Helps people with Parkinson’s or long COVID symptoms • Not ready for clinics but …
Narrative review on multi-omics for spondyloarthritis and psoriatic arthritis
New multi-omics strategies help doctors better understand spondyloarthritis and psoriatic arthritis conditions
This narrative review synthesizes evidence on multi-omics strategies for spondyloarthritis and psoriatic arthritis. It argues that integrati…
Doctors are using advanced genetic and protein tests to study spondyloarthritis and psoriatic arthritis. These new methods help find better …
Network meta-analysis of immunomodulatory therapies for sepsis mortality
Ulinastatin and other immune drugs may lower death risk in sepsis
This systematic review and network meta-analysis of 76 RCTs in 22,194 patients with sepsis synthesized evidence on immunomodulatory therapie…
A large review of 76 trials found ulinastatin and other immune therapies can reduce death risk in sepsis patients.
Narrative review suggests suprachoroidal injections may improve vision and reduce edema in diabetic macular edema
New eye injection method reduces shots and protects vision for diabetics
This narrative review examines suprachoroidal space injections versus conventional intravitreal therapies for diabetic macular edema. The au…
A new injection technique for diabetic eye disease could spare patients from frequent shots and lower the risk of cataracts while improving …
Case report describes rare coexistence of giant cell tumor and enchondroma in a 36-year-old woman
A Rare Tumor Duo Found in a Woman's Hip Bone
This case report describes a 36-year-old woman with a rare coexistence of giant cell tumor of bone and enchondroma. Histopathology revealed …
A 36-year-old woman with hip pain was found to have two distinct tumors in her pubic bone, a rare combination that highlights the need for c…