Linezolid continuous infusion increases clinical cure rates and pharmacodynamic target attainment compared to intermittent infusion
Continuous infusion of linezolid shows higher rates of clinical cure
This meta-analysis of 389 patients found that linezolid continuous infusion (CI) resulted in higher clinical cure rates (RR=1.33) and higher…
Giving linezolid through a continuous infusion may lead to better clinical success and higher drug targets than standard intermittent dosing…
Lung Ultrasound Matches HRCT for ILD Screening in Rheumatoid Arthritis
Lung Ultrasound Shows Promise for Screening Rheumatoid Arthritis Patients
A systematic review of 10 articles finds lung ultrasound is an effective screening tool for interstitial lung disease in rheumatoid arthriti…
Lung ultrasound may serve as an effective screening tool for interstitial lung disease in patients with rheumatoid arthritis, similar to sta…
Rituximab addition to cyclophosphamide and glucocorticoids may treat refractory ANCA-positive retroperitoneal fibrosis
Adding rituximab helps treat a rare and difficult condition
This case report describes a patient with MPO-ANCA-positive retroperitoneal fibrosis who showed significant lesion regression after the addi…
Adding rituximab to standard treatment may help shrink lesions in patients with a rare condition called retroperitoneal fibrosis.
Elevated neutrophil-to-lymphocyte ratio correlates with disease activity in patients with systemic lupus erythematosus
Neutrophil Levels Linked to Activity in Lupus Patients
This meta-analysis of 4,006 SLE patients and 2,576 healthy controls found that a significantly higher neutrophil-to-lymphocyte ratio (NLR) i…
A large study of over 4,000 patients found that specific blood cell ratios may help track how active lupus disease is in different populatio…
Metabolic Syndrome Common in Lupus, Linked to Age and Cholesterol
Lupus patients face higher risk of metabolic syndrome
A meta-analysis finds metabolic syndrome is frequent in lupus patients, with age, BMI, and cholesterol levels driving risk.
Living with lupus can increase the risk of metabolic syndrome, a cluster of conditions that impact heart health and weight.
Continuous oximetry and capnography detect more respiratory abnormalities than intermittent assessment in opioid-induced respiratory depression
New technology helps detect breathing problems caused by opioid use
This narrative review examines the role of continuous monitoring and machine-learning tools in detecting opioid-induced respiratory depressi…
Continuous monitoring and machine learning offer more ways to catch dangerous breathing issues in patients using opioids after surgery.
Inflammaging may explain heightened anaesthetic sensitivity in older adults, but clinical evidence is limited
Older adults show higher sensitivity to anesthesia during surgery
This narrative review examines how age-related immune dysregulation (inflammaging) may contribute to increased anaesthetic sensitivity in ol…
Aging can change how the body reacts to anesthesia, making older adults more sensitive to the drugs used during surgery.
Safety Profile Analysis of Immune Checkpoint Inhibitor Combinations in Metastatic Prostate Cancer
Adding immune checkpoint inhibitors to endocrine therapy increases cancer side effects
A network meta-analysis of 8,197 patients reveals that adding immune checkpoint inhibitors to endocrine therapy significantly increases toxi…
Adding immune checkpoint inhibitors to endocrine therapy for metastatic prostate cancer significantly increases the risk of serious and fata…
Distinct immune mechanisms and myeloid-cell activation differentiate systemic juvenile idiopathic arthritis from adult rheumatoid arthritis
New Research Highlights Differences Between Juvenile and Adult Arthritis
This narrative review synthesizes the distinct immune mechanisms and biomarker profiles of juvenile idiopathic arthritis (JIA) and adult rhe…
New research highlights how juvenile idiopathic arthritis differs from adult rheumatoid arthritis, helping doctors better tailor treatments …
Barriers to clinical trial participation in rural Australia include cultural gaps and logistical costs
Trial Activity in Rural Australia Shows Gaps in Cancer Care
This scoping review of 24 studies examines clinical trial activity and infrastructure in rural, regional, and remote Australia. It identifie…
New research highlights the need for better clinical trial access and culturally safe designs for cancer patients in rural and remote Austra…
Atopic dermatitis is associated with increased odds of autism and learning disabilities in children
Atopic Dermatitis Linked to Higher Odds of Neurodevelopmental Disorders
This systematic review and meta-analysis of observational studies analyzed 39 studies to evaluate the link between atopic dermatitis and neu…
A review of 39 studies found that children with atopic dermatitis may have higher odds of conditions like ADHD and autism.
Concurrent lupus nephritis and Graves' disease improved with combined immunosuppression and methimazole in a single case
Case Report Shows Treatment for Concurrent Lupus and Graves Disease
This case report describes a 39-year-old male with biopsy-proven ISN/RPS Class IV + V lupus nephritis and Graves' disease who showed early c…
A new case report describes a treatment plan for a patient managing both lupus nephritis and Graves disease at the same time.