Comprehensive genomic profiling finds 0.2% NTRK fusion prevalence across solid tumors in community health system
Study finds rare NTRK gene fusions in 0.2% of solid tumors in community health system
An observational cohort study of 15128 adult patients with solid tumors in a community health system found a 0.2% prevalence of pathogenic N…
Only 0.2% of solid tumors in a large community health system carry rare NTRK gene fusions, yet testing found eight new fusion types never de…
CA-1 levels elevated in aqueous humor of DME patients compared to controls in cross-sectional study
Study finds elevated protein levels in eye fluid of patients with diabetic macular edema
A retrospective cross-sectional study of 74 DME patients and 30 controls found carbonic anhydrase-1 (CA-1) levels in aqueous humor were mark…
Patients with diabetic macular edema have eye fluid protein levels about 10 times higher than those without the condition.
Meta-analysis finds nausea in 24% and abdominal pain in 20% of RA patients on methotrexate
How common is nausea and stomach pain for RA patients on methotrexate?
A systematic review and meta-analysis of 37 studies involving 19,986 adult RA patients on methotrexate found pooled prevalence rates of 24.3…
Nearly one in five rheumatoid arthritis patients taking methotrexate experience nausea or stomach pain, with about 8.5% stopping the drug du…
Review explores immunopathology of dry eye disease and emerging drug delivery systems
Why do dry eye treatments often fail? A new review points to inflammation.
A systematic review examines immunopathological mechanisms in dry eye disease and recent advances in ophthalmic drug delivery systems. The a…
Why do dry eye drops often fail? A new review shows inflammation, not just dryness, drives the disease, while new delivery systems aim to fi…
Menopausal hormone therapy associated with modestly increased rheumatoid arthritis risk in meta-analysis
Menopausal hormone therapy linked to small increase in rheumatoid arthritis risk
A systematic review and meta-analysis of 5 studies with over 22 million person-years of follow-up in postmenopausal women found menopausal h…
Women using menopausal hormone therapy face a slightly higher risk of developing rheumatoid arthritis, particularly with long-term use.
Case series identifies MSH2 variants in three families suspected of Lynch syndrome
Genetic study identifies Lynch syndrome variants in three families with colon cancer history
A case series of three families with suspected Lynch syndrome used whole-exome sequencing and immunohistochemistry to characterize MSH2 vari…
Genetic testing found new disease-causing variants in three families with colon cancer history, offering clues for precision screening and g…
Meta-analysis finds 3.58% stroke incidence after lung transplant, linked to 3-fold mortality increase
How often do strokes happen after a lung transplant? A new review finds out.
A systematic review and meta-analysis of 33,175 adult lung transplant recipients from 17 studies found a pooled stroke incidence of 3.58%. S…
A stroke after a lung transplant triples the risk of death, a new review of 33,000 patients found, though the exact rate varies by hospital.
Retrospective study finds inverse association between NHHR and osteoporotic fracture risk
Study finds link between cholesterol ratio and lower fracture risk in hospital patients
A retrospective cross-sectional cohort study of 580 patients from a Chinese endocrinology department found a significant inverse association…
Higher cholesterol ratios linked to lower fracture risk in hospital patients, with highest levels showing 80% reduced odds of osteoporotic b…
Case report: Ravulizumab successfully treated COVID-19-triggered complement-mediated TMA in a kidney transplant recipient
Doctors report a single case where ravulizumab treated a rare blood disorder after COVID-19 in a kidney transplant patient.
A case report describes a 75-year-old kidney transplant recipient who developed complement-mediated thrombotic microangiopathy (CM-TMA) trig…
A kidney transplant patient with COVID-19 improved after doctors treated a rare blood disorder with ravulizumab, showing age shouldn't block…
Phase III trial of AK111 for active ankylosing spondylitis completed with 510 patients
Can a new drug help people with painful spinal arthritis move more freely?
A Phase III, randomized, double-blind, placebo-controlled, multicenter study evaluated AK111 in 510 patients with active ankylosing spondyli…
A new drug called AK111 aims to help people with painful spinal arthritis move more freely by improving symptoms like pain and stiffness.
Phase 3 trial compares bimekizumab to placebo and ustekinumab for moderate to severe plaque psoriasis
Can a new psoriasis drug outperform an established treatment?
A phase 3 randomized controlled trial enrolled 567 adults with moderate to severe chronic plaque psoriasis to compare bimekizumab against pl…
A new psoriasis drug called bimekizumab is being tested against existing treatments in a major trial involving 567 adults to see if it helps…
Canakinumab shows efficacy in Japanese AOSD patients in Phase 3 open-label study
Could a monthly injection help control the painful flares of Adult-Onset Still's Disease?
A Phase 3, open-label, single-arm study evaluated canakinumab in 14 Japanese patients with Adult-Onset Still's Disease. The primary outcome …
A monthly injection helped Japanese patients with Adult-Onset Still's Disease achieve meaningful symptom relief, supporting approval for thi…