FDA Approves Prolia (denosumab) for Osteoporosis and Bone Loss in Multiple Settings
FDA approves new drug Prolia for osteoporosis and bone loss
FDA approved Prolia (denosumab) for postmenopausal osteoporosis, male osteoporosis, glucocorticoid-induced osteoporosis, and bone loss in me…
The FDA approved Prolia (denosumab) to treat osteoporosis and bone loss in certain patients. It is for postmenopausal women, men with osteop…
JAK and IL-6 inhibitors outperform TNF inhibitors for activity limitation in rheumatoid arthritis
Specific Biologic Drugs Show Better Results for Rheumatoid Arthritis
This meta-analysis of 99 studies evaluated patient-reported outcomes (PROs) in patients with rheumatoid arthritis treated with b/tsDMARDs. T…
New analysis shows that certain types of biologic drugs may better reduce activity limits and improve mental health for people with rheumato…
Extreme temperature exposure may worsen COPD outcomes in Chinese populations, protocol outlines
Extreme heat and cold may worsen COPD outcomes
This study protocol describes a planned systematic review and meta-analysis examining the association between extreme temperature exposure (…
A new review will examine how extreme temperatures affect COPD patients in China, potentially leading to more hospitalizations.
Strengthening-based rehabilitation improves knee muscle strength following ACL reconstruction but shows no effect on hop performance
Strength Training Improves Muscle Strength After ACL Reconstruction Surgery
This meta-analysis of 9 trials and 24 effect sizes indicates that strengthening-based rehabilitation significantly improves knee muscle stre…
New analysis shows that strength-based rehabilitation improves muscle strength after ACL surgery, though results for hop performance were no…
Atypical granular cell tumor requires immunohistochemical detection and multimodal imaging to avoid common misdiagnosis as schwannoma
Rare Thigh Tumor Diagnosed With Imaging and Biopsy
This case report and literature review describes an atypical granular cell tumor in a 49-year-old male. The authors highlight that while the…
A man's thigh mass turned out to be a rare granular cell tumor, highlighting the need for careful diagnosis.
TCM influenza research surges after 2020, shifting from clinical practice to mechanistic studies
Traditional Chinese Medicine Research on Influenza Surges After 2020
A systematic bibliometric analysis of 1,527 publications maps the landscape of Traditional Chinese Medicine (TCM) research on influenza. The…
A review of 1,527 publications shows TCM research for influenza has grown rapidly since 2014, with a sharp rise after 2020. China leads in o…
CAR-T cell therapy for lymphoid malignancies presents a biphasic pattern of infectious complications
CAR-T Cell Therapy Shows Specific Patterns of Infection Risks
This narrative review examines the incidence patterns of bacterial, viral, and opportunistic infections in patients receiving CAR-T cell the…
Patients receiving CAR-T cell therapy for lymphoid malignancies may face different types of infections during early and late stages of treat…
Six paradigm shifts reframe preeclampsia as a first-trimester villous trophoblast syndrome
New Research Reframes the Origins of Preeclampsia
This narrative review synthesizes six inter-related paradigm shifts in placental pathophysiology, reframing preeclampsia as a first-trimeste…
New research suggests preeclampsia begins in the first trimester, potentially allowing for earlier detection and more diverse ways to assess…
Sulbactam-durlobactam and tigecycline provide clinical improvement for polymicrobial infections in severe acute pancreatitis
New drug combination shows promise for severe pancreatic infections
This case report describes the use of sulbactam-durlobactam and tigecycline for a 51-year-old male with severe acute pancreatitis and organ …
A new antibiotic combination helped a patient with a life-threatening infection that was resistant to many common drugs.
Combination therapies of plant-derived compounds outperform monotherapy for psoriasis vulgaris with specific immunological profiles
Plant compounds combined with standard care improve psoriasis symptoms
This systematic review and network meta-analysis of 84 randomized controlled trials involving 7,544 patients found that combination therapie…
Combining specific plant-derived ingredients with standard treatments may offer better results for people living with psoriasis.
EMG-based bioelectrical feedback improves Fugl-Meyer scores by 9.50 points in post-stroke hemiplegia
Bioelectrical Feedback Improves Motor Function After Stroke
This systematic review and meta-analysis of 8 studies found that EMG-based bioelectrical feedback significantly improved motor function comp…
A review of clinical data shows that bioelectrical feedback can improve motor skills and daily activities for people with post-stroke hemipl…
Continuous renal replacement therapy may support metabolic and circulatory stability in preterm infants with AKI
CRRT Treatment Shows Promise for Infants with Kidney Injury
This case report and literature review describes the use of continuous renal replacement therapy (CRRT) for a very low birth weight preterm …
A new case report highlights how continuous renal replacement therapy may help stabilize very low birth weight infants facing acute kidney i…