In elderly AIS patients, BT and DMT showed comparable outcomes, with CRP and puncture time predicting prognosis.
Comparison of two stroke treatments shows similar outcomes in older patients
This single-center retrospective study compared bridging thrombectomy (BT) and direct mechanical thrombectomy (DMT) in 87 patients aged 75 y…
For stroke patients over 75, both bridging and direct clot removal offer similar recovery, but delayed treatment and high inflammation raise…
Seven patients with metamizole-induced agranulocytosis required ICU admission, resulting in two deaths and severe complications.
Seven patients needed ICU care for severe reactions to metamizole
This retrospective cohort study examined seven patients admitted to an ICU in southern Germany due to metamizole-induced agranulocytosis. Am…
Seven patients needed ICU care for severe reactions to metamizole, with two deaths from multiorgan failure and survivors facing life-threate…
HIF-1α polymorphism linked to lower metabolic syndrome odds in HIV patients on ART
Could a specific gene variant help protect people with HIV from metabolic syndrome?
A cross-sectional study of 121 people living with HIV on antiretroviral therapy found the HIF-1α rs11549465 T allele and CT/CT+TT genotypes …
A specific gene variant may help protect people with HIV on treatment from metabolic syndrome, a cluster of conditions that raises heart dis…
FPGS Gene Variants Linked to Methotrexate Efficacy and Toxicity in Rheumatoid Arthritis
Could your genes explain why methotrexate works better for some people?
A meta-analysis of 2345 rheumatoid arthritis patients on methotrexate found FPGS polymorphisms rs10106 and rs1544105 were significantly asso…
Your genes might explain why methotrexate works better for some rheumatoid arthritis patients but also raises their risk of harmful side eff…
Febuxostat-Charcoal Combo Fails to Improve Urate Control but Reduces Gout Flares in RCT
Gout study finds combination treatment reduces flares but not urate levels
A 24-week RCT in 348 primary gout patients found adding activated charcoal to febuxostat 20 mg did not improve serum urate control versus fe…
Adding activated charcoal to gout medication reduced painful flares and cholesterol, but failed to lower urate levels better than standard t…
Retrospective study identifies imaging biomarkers for AMD progression using machine learning models
Can an eye scan predict who will lose central vision from macular degeneration?
A retrospective cohort study of 324 AMD patients developed machine learning models to predict progression from early to late AMD over 3 year…
Eye scans showing pigment changes and drusen deposits can predict which patients with early macular degeneration are most likely to lose cen…
Itch prevalence and severity remain stable over time in systemic sclerosis cohort study
For people with scleroderma, how common is itch — and does it ever go away?
An observational cohort study of 2173 people with systemic sclerosis found itch prevalence was 35-37% and mean severity 4.1-4.4 on a 0-10 sc…
For people with scleroderma, a new study shows itch is common and stays steady over time, challenging the idea that it is just an early-phas…
Procalcitonin shows moderate accuracy for bloodstream infection detection in retrospective cohort
Blood test shows promise in detecting bacterial infections and identifying their type
A retrospective cohort study of 251 bacterial isolates from positively flagged blood cultures in South India found procalcitonin (PCT) had 7…
A blood test detected bloodstream infections with 83% accuracy, showing slightly higher levels for Gram-negative bacteria like E. coli and K…
Reduced anti-CXCR3 antibodies associated with systemic autoimmunity and atherosclerosis in cohort study
Study finds link between specific antibody levels and heart disease risk in autoimmune conditions
An observational cohort study of patients with rheumatoid arthritis, Sjogren disease, and controls found reduced anti-CXCR3 antibody levels …
Low levels of a specific antibody in early arthritis and joint pain are linked to higher heart disease risk and poorer medication responses.
Meta-analysis finds elevated neutrophil-to-lymphocyte ratio in SLE, with weak correlation to disease activity
Can a simple blood test help track lupus activity? The evidence is mixed.
A meta-analysis of 40 studies with external validation (n=290) found neutrophil-to-lymphocyte ratio (NLR) was higher in SLE patients versus …
A simple blood ratio tracks lupus activity better than healthy levels, but its accuracy varies by ethnicity and treatment, so it isn't ready…
Southeastern US states show highest arthritis-related severe joint pain and inactivity
Where does arthritis hurt the most? Southeastern states show highest pain and inactivity.
A 2017 US observational study found age-standardized prevalence of severe joint pain and physical inactivity among adults with arthritis was…
Adults with arthritis in the southeastern United States reported the highest levels of severe joint pain and physical inactivity compared to…
National prevalence of arthritis and associated activity limitations in U.S. adults examined
How many Americans live with arthritis that limits their daily activities?
An observational study assessed the national prevalence of arthritis and arthritis-attributable activity limitation among U.S. adults. The m…
A new report reveals how many Americans live with arthritis that limits their daily physical activities.