High CD103+ tumor-infiltrating lymphocyte density correlates with improved survival in muscle-invasive bladder cancer
High immune cell density linked to better survival in bladder cancer
This meta-analysis of 3 studies involving 6 cohorts indicates that high CD103+ tumor-infiltrating lymphocyte density is associated with prol…
A specific type of immune cell may signal a better outlook for patients with muscle-invasive bladder cancer.
Enfortumab vedotin cutaneous toxicity and peripheral neuropathy are associated with improved outcomes in urothelial carcinoma
Skin Reactions and Nerve Issues Linked to Better Survival
This meta-analysis evaluates the association between enfortumab vedotin-related adverse events and clinical outcomes in patients with advanc…
A review of patients with advanced urothelial carcinoma suggests that certain side effects from enfortumab vedotin may link to improved surv…
Females with advanced bladder cancer show significantly better progression-free survival on enfortumab vedotin
Women with bladder cancer show better outcomes on specific treatment
This meta-analysis of 17 studies evaluated sex-specific outcomes for patients with advanced or metastatic urothelial cancer treated with enf…
Women with advanced bladder cancer may experience longer periods without disease progression when treated with enfortumab vedotin.
Intraoperative Positioning Strategies Raise Stone-Free Rates in RIRS for Renal Calculi
New Positioning Strategies May Improve Success Rates for Kidney Stones
This meta-analysis of 998 patients undergoing retrograde intrarenal surgery for renal calculi found that intraoperative positioning strategi…
Specific positioning during kidney stone surgery may lead to higher stone-free rates compared to standard methods for patients undergoing RI…
Alpha-adrenergic receptor antagonists improve trial without catheter success by 24.5% in men with AUR and BPH
Alpha Blockers Improve Success Rates for Men with Blocked Bladders
This meta-analysis of randomized controlled trials indicates that alpha-adrenergic receptor antagonists significantly improve the success ra…
Men with blocked bladders due to enlarged prostates may have a much better chance of avoiding a catheter when using specific medications.
Gene Methylation Detection Explored for Cervical Cancer Screening Integration
Gene methylation detection may improve cervical cancer screening methods
This systematic review examines gene methylation detection as an emerging approach for cervical cancer screening. The authors synthesize the…
Newer ways to detect gene changes could help doctors find cervical cancer earlier and improve how they screen patients.
Histone lactylation links glycolysis to salivary gland fibrosis in Sjogren's disease
Scientists Link Cell Metabolism to Sjogren's Gland Damage
This systematic review synthesizes evidence from immunometabolism, epigenetic rewiring, and tissue fibrogenesis to propose histone lactylati…
A new review suggests a cell process called histone lactylation may help explain salivary gland damage in Sjogren's disease.
Establishment of expected 24-hour urine ranges in healthy adults without kidney stone disease
New data establishes expected ranges for 24-hour urine tests
Researchers established expected ranges for various 24-hour urine components in healthy adults without kidney stone disease. While several d…
New data provides clear expected ranges for 24-hour urine tests, helping clarify what is considered normal for people without kidney stones.
Teaching clinical judgment biases using case vignettes improves veterinary student decision making and situational awareness
Teaching Bias With Vignettes May Improve Veterinary Judgment
This narrative review explores the educational utility of using clinical case vignettes to teach cognitive biases to veterinary students. Th…
A new review suggests that teaching veterinary students about cognitive biases using clinical vignettes could improve their judgment.
Etoposide plus cisplatin produces substantial but temporary regression in metastatic prostatic small cell neuroendocrine carcinoma
Surgery and Chemotherapy Provide Temporary Relief for Prostate Cancer
This case report describes a patient with de novo metastatic prostatic small cell neuroendocrine carcinoma treated with etoposide plus cispl…
A specific chemotherapy combination and surgery can shrink tumors and relieve urinary blockage in a rare form of prostate cancer.
Neurological involvement in localized scleroderma includes central and peripheral nervous system symptoms and imaging findings
Neurological Symptoms and Imaging Findings in Localized Scleroderma
This systematic review of 242 publications involving 3,500 patients identifies common neurological symptoms and neuroimaging findings in loc…
New research highlights common neurological symptoms like migraines and facial pain in patients with localized scleroderma.
Long-read sequencing and assembly tools facilitate detection of complex viral integration structures in various cancers
New Guide Maps Best Tools to Find HPV Integration
This systematic review evaluates the use of long-read sequencing technologies and assembly tools for identifying complex viral integration s…
A new review compares DNA sequencing tools for spotting how HPV inserts itself into cancer cells, a key step in several cancers.