Adjuvant PD-1 inhibitors significantly improve disease-free survival in patients with resected high-risk muscle-invasive bladder cancer
PD-1 Inhibitors Improve Survival for Muscle Invasive Bladder Cancer
This meta-analysis of Phase 3 trials indicates that adjuvant nivolumab or pembrolizumab improves disease-free survival (DFS) in patients wit…
New data suggests that PD-1 inhibitors like nivolumab or pembrolizumab may improve disease-free survival for patients with high-risk bladder…
PSMA-targeted radioguided surgery shows high diagnostic accuracy in prostate cancer meta-analysis
PSMA guided surgery shows better accuracy for prostate cancer
This meta-analysis of 28 studies evaluates PSMA-targeted radioguided surgery (PSMA-RGS) for prostate cancer. PSMA-RGS demonstrated high sens…
New data shows that PSMA targeted radioguided surgery provides higher accuracy than standard imaging to find and locate prostate cancer.
PSMA-targeting radiotracers exhibit varying liver background uptake levels impacting patient selection for targeted therapy
PET scan tracer choice may affect prostate cancer treatment eligibility
This systematic review and meta-analysis of 17 studies involving 1497 patients evaluated four PSMA-targeting PET radiotracers. The analysis …
Which PET tracer you get for prostate cancer could change whether you qualify for targeted therapy. A new analysis shows big differences in …
FANCI overexpression linked to poor prognosis in multiple cancers, review finds
Protein called FANCI may play role in cancer progression
This narrative review examines the multifaceted roles of FANCI, a Fanconi anemia protein, in DNA repair and cancer. The authors report that …
A protein known as FANCI helps repair DNA but its presence in high amounts can lead to worse outcomes for some cancer patients.
DAPT and aspirin show potential for managing minor acute ischemic stroke based on SUCRA rankings
Best stroke treatment may depend on your goal
This network meta-analysis of 26,176 patients evaluated 9 antithrombotic interventions for minor acute ischemic stroke. The analysis suggest…
For minor stroke, the best treatment varies by what matters most: quick recovery, preventing another stroke, or avoiding bleeding.
Immune-mediated approaches like BCG and oncolytic viruses show the most advanced clinical translation in bladder cancer
Living cancer therapies show promise for bladder cancer
This narrative review examines Living Cancer Therapeutics (LCTs), including bacteria, viruses, and microbiome-based oncobiotics for urinary …
A review finds five ways living therapies like bacteria and viruses could fight bladder cancer, but most are still early-stage.
Large fistula size and severe peri-fistula fibrosis significantly increase recurrence risk in vesicovaginal fistulas
Specific surgical factors predict recurrence of vesicovaginal fistulas
This systematic review of 21 studies identifies key predictors for vesicovaginal fistula (VVF) recurrence. Significant risks include large f…
Identifying specific risk factors like fistula size and tissue scarring helps doctors better predict if a vesicovaginal fistula will return …
Omission of postoperative double-J stents after uncomplicated URS reduces pain and analgesic requirements
Skipping Stents After Kidney Stone Surgery Reduces Patient Pain
This meta-analysis of randomized trials involving 3572 adults with ureteral and renal stones found that omitting double-J stents after uncom…
Patients undergoing ureteroscopy for kidney stones may experience less pain and fewer complications if a double-J stent is not used after su…
Active stone-directed intervention reduces odds of composite recurrence and surgery for asymptomatic kidney stones
Active Intervention Reduces Surgery for Patients with Kidney Stones
This meta-analysis of 592 patients found that active stone-directed intervention significantly reduced the odds of composite recurrence (OR …
Active treatment for asymptomatic kidney stones may lower the risk of future surgeries and stone growth while maintaining a similar safety p…
Long-read sequencing improves detection of structural variants and methylation patterns in liquid biopsy
Long-read sequencing improves detection of cancer signals in blood
This mini-review examines the application of long-read sequencing (LRS) for liquid biopsy, specifically focusing on cfDNA and ctDNA. The aut…
Newer long-read sequencing technology helps doctors identify complex genetic changes and the source of tumors in lung, brain, and pediatric …
Curcumin supplementation improves IPSS scores by 4.11 points in men with benign prostatic hyperplasia
Curcumin Shows Potential for Managing Benign Prostatic Hyperplasia Symptoms
This meta-analysis of 697 patients evaluated curcumin as an adjunct for benign prostatic hyperplasia (BPH). The analysis found a significant…
New research suggests that curcumin may help improve urinary symptoms and prostate health in men with enlarged prostates.
Leptin expression in seminal plasma is significantly higher in infertile patients with varicocele than controls
Infertile men with varicocele have higher leptin in their semen than healthy controls
This systematic review and meta-analysis examined leptin expression in seminal plasma and serum leptin levels in infertile patients with var…
A new analysis shows men with varicocele have significantly higher leptin in their semen. This finding might help explain why some struggle …