N/A
N=538
Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes
Schizophrenia
Bottom Line
View on ClinicalTrials.gov: NCT00108303 ↗Enrolled (actual)
538
Serious AEs
0.0%
Results posted
Jan 2016
Primary outcome: Primary: Genetic Linkage — 5.2 log (odds ratio) — p=<0.001
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Diagnostic (Other)
- Age
- Pediatric, Adult, Older Adult · 1+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Dec 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Genetic Linkage |
5.2 | <0.001 sig |
| PRIMARY Heritability Coefficient |
0.5; 0.5; 0.1 | 0.001 sig |
| PRIMARY Log of the ODDS of Linkage |
5.2; 5.2; 1 | — |
Summary
Schizophrenia has long been known to be an illness with significant evidence for a genetic predisposition. The purpose of this study is to determine the genetic abnormalities that cause childhood and adult onset schizophrenia.
Eligibility Criteria
Inclusion Criteria
- Individuals thought to have schizophrenia or schizoaffective disorder, be the parent of such an individual, or be in the matched control group of unrelated individuals not thought to have schizophrenia or schizoaffective disorder
Exclusion Criteria
- Unable to give informed consent;
- Psychotic disorder judged to be secondary to substance abuse, psychotic disorder that appears to be secondary to a known medical or neurological disorder, or severe mental retardation
Data sourced from ClinicalTrials.gov (NCT00108303). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.