N/A
Completed N=1,223
Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients
Source: ClinicalTrials.gov NCT00133978 ↗Enrolled (actual)
1,223
Serious AEs
3.8%
Results posted
Sep 2014
Primary outcomePrimary: 28-day Mortality — 97; 89; 101; 76 participants
Summary
The purpose of this study is to determine whether providing high dose glutamine and antioxidants to critically ill patients will be associated with improved survival.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY 28-day Mortality |
97; 89; 101; 76 | — |
| SECONDARY ICU Length of Stay |
8.9; 8.9; 8.9; 8.3 | — |
| SECONDARY ICU Acquired Infection |
183; 166; 168; 181; 118; 120 | — |
| SECONDARY Hospital Length of Stay |
17.1; 16.0; 16.9; 16.5 | — |
Eligibility Criteria
Inclusion Criteria
- Mechanically ventilated patients > or = 18 years old
- 2 or more organ failures related to acute illness
Exclusion Criteria
- > 24 hours from admission to ICU
- Patients who are moribund
- Lack of commitment to aggressive care
- Absolute contraindication to enteral nutrients
- Severe acquired brain injury
- Routine elective cardiac surgery
- Primary admission of burns > 30% body surface area
- Weight 200 kgms
- Pregnant or lactating patients
- Previous randomization in this study
- Enrollment in a related ICU interventional study
- Child's class C liver disease
- Metastatic cancer with life expectancy < 6 months
- Seizure disorder requiring anticonvulsant medication
Data sourced from ClinicalTrials.gov (NCT00133978). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.