Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
Cystatin C shows promise for early detection of kidney injury
This meta-analysis of 17 studies evaluates the diagnostic performance of Cystatin C for detecting acute kidney injury in patients with sepsi…
A new look at 17 studies suggests that Cystatin C could help doctors identify kidney damage in sepsis patients much earlier than current met…
Sepsis Mortality Prediction Models Show Moderate Performance
Prediction models show moderate success in forecasting sepsis deaths
A meta-analysis of 84 studies finds that externally validated models for sepsis mortality achieve a pooled AUC of 0.794, but most studies ha…
New data from millions of records helps identify which factors most accurately predict if a patient with sepsis will survive.
Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients
Machine Learning Models Show Mixed Results for Predicting Sepsis Lung Injury
This systematic review and meta-analysis evaluated prediction models for ARDS occurrence and short-term mortality in patients with sepsis-as…
New analysis shows that while machine learning can predict lung injury in sepsis patients, these models do not consistently outperform stand…
Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
Sepsis may damage kidneys by letting gut bacteria toxins leak into the blood
This narrative review examines the role of gut microbiota dysbiosis in sepsis-associated acute kidney injury and acute kidney injury. The au…
A review suggests that sepsis changes gut bacteria, causing harmful toxins to leak and hurt kidneys in humans and animals.
Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
Review discusses neutrophil modulation in sepsis for critically ill patients
This narrative review discusses modulation of neutrophil function and death in critically ill patients with sepsis. The authors synthesize c…
This narrative review explores how changing neutrophil function might affect sepsis outcomes in critically ill patients, though no specific …
Source control and antibiotic stewardship remain cornerstones of sepsis management
Review prioritizes antibiotic stewardship over live probiotics for sepsis
This narrative review synthesizes current evidence on sepsis management, emphasizing source control and antibiotic stewardship as key pillar…
A narrative review suggests avoiding live probiotics in high-risk sepsis patients while prioritizing antibiotic stewardship and source contr…
Antibiotic stewardship bundle aims to cut antibiotic use in Chinese NICUs
A new plan aims to cut unnecessary antibiotics for sick newborns in China
This protocol describes a multicenter, before-and-after, interrupted time series quality improvement study testing a bundled antimicrobial s…
This ongoing project in China seeks to reduce antibiotic use for newborns with sepsis while keeping them safe during treatment.
Interleukin-7 therapy improves lymphocyte counts in sepsis and COVID-19 patients
Recombinant human interleukin-7 boosts white blood cells but does not save lives in sepsis or COVID-19
A meta-analysis shows recombinant IL-7 boosts lymphocytes in sepsis and COVID-19, but only reduces secondary infections in COVID-19.
A new analysis shows this drug raises low white blood cell counts in sepsis and COVID-19 but does not lower death risk or improve survival.
Antioxidant nanomedicine in sepsis: a narrative review with no reported outcomes or safety data
Antioxidant nanomedicine review explores sepsis treatment options
This narrative review discusses antioxidant nanomedicine for sepsis. The authors note that key details such as population, sample size, outc…
A review looks at antioxidant nanomedicine for sepsis, a serious infection that kills many people. More research is needed to see if this ap…
Systematic review and meta-analysis of sepsis screening tools in low- and middle-income countries
Sepsis screening tools show mixed accuracy in low-income country adult patient groups
This systematic review and meta-analysis evaluated sepsis screening tools in adult populations in low- and middle-income countries. It found…
A review of thirty thousand patients found that common sepsis checklists work differently in low-income areas. Some tools miss cases while o…
Systematic review of acupuncture for sepsis-associated acute gastrointestinal injury
Acupuncture helped some sick patients feel better but did not save more lives in this review
This systematic review and meta-analysis synthesized evidence on adjunctive acupuncture for sepsis-associated acute gastrointestinal injury …
This review looked at acupuncture for very sick people with stomach problems caused by sepsis. While it helped lower inflammation and improv…
Review discusses metabolic reprogramming of macrophages for sepsis-associated acute lung injury with noted limitations
Immune Cell Energy Switch Offers Hope Against Deadly Sepsis Lungs
This narrative review examines the concept of metabolic reprogramming of macrophages as a potential approach for sepsis-associated acute lun…
• Scientists reprogrammed immune cells to calm sepsis lung damage • Helps critically ill patients with few current options • Still in lab te…
Research across Systemic Inflammatory Response Syndrome
Related studies from across the Systemic Inflammatory Response Syndrome family.
Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
Antibiotic reduces maternal infection risk in labor
This secondary analysis of an RCT found that azithromycin reduced maternal infection and sepsis in women in labor, with a larger reduction a…
A single dose of azithromycin during labor lowered maternal infections in a large trial across seven countries.
Systematic Review and Meta-Analysis Finds IL-27 Superior to CRP for Neonatal Sepsis Diagnosis
A New Blood Test May Spot Newborn Sepsis Faster Than Current Methods
This systematic review and meta-analysis of 495 neonates compared IL-27 to C-reactive protein for diagnosing neonatal sepsis. IL-27 showed h…
A simple blood marker called IL-27 catches newborn sepsis more accurately than the standard test, potentially saving lives by speeding up di…
7-Day Antibiotic Regimen Non-Inferior to 14-Day for Uncomplicated Neonatal Sepsis in RCT
Can shorter antibiotics cure newborn sepsis just as well as two weeks of treatment?
This randomized control assessor-blinded trial evaluated 140 neonates weighing ≥ 1000 g with culture-positive sepsis in a tertiary Neonatal …
A 7-day antibiotic course for newborn sepsis worked as well as 14 days, with babies leaving the hospital sooner and needing less breathing s…
AMR strategies in LMIC newborns reduce antibiotic use and mortality in meta-analysis
Strategies to reduce antibiotic resistance may lower infection risks in newborns in low-income countries
A systematic review and meta-analysis of 31 facility-based studies in LMICs found that strategies to reduce antimicrobial resistance, includ…
Strategies to curb antibiotic resistance in newborns in low-income countries lower infection risks and reduce overall mortality.
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
Study identifies potential vaccine targets for deadly newborn infection in Africa
A case-control study of 100 mother-baby dyads in sub-Saharan Africa analyzed antibody responses to 161 K.
Specific bacterial proteins might protect newborns from deadly sepsis via maternal antibodies, paving the way for a vaccine in sub-Saharan A…
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs
Can antiseptics on the umbilical cord save newborns from infection and death?
Meta-analysis shows 4.0% chlorhexidine reduces neonatal mortality (RR 0.86) and omphalitis (RR 0.71) in LMICs, but delays cord separation by…
Applying chlorhexidine to the umbilical cord may lower the risk of infection and death in newborns in low-income countries.
Questions about Sepsis
Does using procalcitonin to guide my sepsis care lower my chance of dying?
Yes, procalcitonin-guided care may lower your chance of dying from sepsis, with studies showing reduced 28-day and long-term mortality.
Full answer →What quality indicators should I expect for my sepsis care in China?
In China, sepsis care quality indicators include timely antibiotic administration, blood culture collection, lactate measurement, and fluid resuscitation, as outlined in a Delphi consensus study.
Full answer →Does having sepsis mean I will face long-term cognitive or physical problems?
Yes, sepsis survivors often face long-term cognitive, physical, and psychological problems known as post-sepsis syndrome, with impairments persisting for months to years.
Full answer →All Sepsis Articles
- Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
- Sepsis Mortality Prediction Models Show Moderate Performance
- Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients
- Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
- Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
- Antibiotic stewardship bundle aims to cut antibiotic use in Chinese NICUs
- Source control and antibiotic stewardship remain cornerstones of sepsis management
- Interleukin-7 therapy improves lymphocyte counts in sepsis and COVID-19 patients
- Antioxidant nanomedicine in sepsis: a narrative review with no reported outcomes or safety data
- Systematic review and meta-analysis of sepsis screening tools in low- and middle-income countries
- Systematic review of acupuncture for sepsis-associated acute gastrointestinal injury
- Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
- Review discusses metabolic reprogramming of macrophages for sepsis-associated acute lung injury with noted limitations
- Secondary analysis of 342 sepsis patients reveals limited diagnostic utility for serum biomarkers in invasive candidiasis diagnosis
- Network meta-analysis of immunomodulatory therapies for sepsis mortality
- Scoping review on androgen pathways and therapy in adult sepsis and septic shock
- Conservative oxygen targets show no mortality difference in mechanically ventilated critically ill adults
- Systematic review and meta-analysis of CALLY index in sepsis patients
- Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure
- Delphi guideline establishes sepsis care quality indicators for Chinese emergency and ICU settings
- Sepsis survivors face high readmission, mortality, and long-term impairments
- Procalcitonin-guided care in sepsis shows no difference in early antibiotic initiation but lower 28-day mortality
- Meta-analysis shows association between adequate antimicrobial therapy and reduced hospital length of stay
- Narrative review on multi-omic technologies for pediatric sepsis biomarker discovery
- Narrative review of Shenfu Injection for sepsis-induced gastrointestinal injury and septic shock
- Large language models show varying accuracy for data extraction in sepsis guidelines
- Sarcopenia in older patients with sepsis is associated with specific plasma metabolomic changes
- Systematic review identifies dual role of NLRP3 inflammasome in sepsis induced immune dysregulation
- Active sepsis prevention program reduces maternal infection-related complications in Malawi and Uganda
- Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes
- Narrative review of Dachengqi Decoction for sepsis-induced organ injury
- Early enteral nutrition linked to favorable biomarker trajectories and lower mortality risk in adult ICU sepsis patients
- Serum N-myc and STAT interactor (NMI) levels predict 30-day mortality and septic shock in adult sepsis patients
- Narrative review explores immunopathological framework for complicated intra-abdominal infection and intra-abdominal sepsis
- Elevated pre-sepsis vitamin B12 levels associated with increased 90-day mortality in adults with sepsis
- Narrative review discusses natural bioactive compounds in sepsis with noted pharmacokinetic and safety limitations
- Gut Microbiota Dysbiosis Linked to Sepsis in Infants and Young Children With Severe Pneumonia
- Dataset describes continuous monitoring in premature VLBW infants across four US NICUs
- Longitudinal biomarker trajectories differ in burn sepsis survivors and non-survivors
- Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants
- Sterile-site yeast isolates linked to fungemia, sepsis, and mortality in a retrospective cohort study
- Prospective observational study of inflammatory mediators in adult ED patients with suspected infection
- Meta-analysis of 34 Studies Shows Buffered Solutions Do Not Lower Mortality Compared to 0.9% Saline
- Narrative review covers IBD, bile acid malabsorption, IBS-D, CRC, obesity, NAFLD, and sepsis-related intestinal injury
- Meta-analysis finds preadmission metformin use associated with reduced mortality in diabetic sepsis patients
- Systematic review proposes S100A8/A9–NETosis feedback loop as core sepsis mechanism
- Review of preclinical EVs for sepsis-associated acute lung injury
- Hematocrit–albumin gap linked to sepsis risk in ICU adults in retrospective analysis
- MAIT cell frequency decreased in sepsis-related liver injury, with altered phenotype and function in murine models
- Narrative review on sepsis and the microbiome, highlighting unresolved causality and variability
- Insulin administration associated with lower 28-day mortality in non-diabetic sepsis patients
- Corticosteroids reduce short-term and long-term mortality in adult sepsis patients according to a systematic review
- Biomarkers and clinical factors show statistical associations with sepsis-induced coagulopathy in 37,459 patients
- Protein nutritional support in critically ill adults shows heterogeneous mortality benefits and potential harm from very high early doses
- Vital sign trajectories in early ICU sepsis thrombocytopenia link to mortality risk
- A 1-hour sepsis bundle is associated with reduced short-term mortality compared to non-bundle care in a meta-analysis of 4435 patients
- Immune dysregulation score predicts mortality and identifies hydrocortisone responders in community-acquired pneumonia
- RDW trajectories during sepsis hospitalization predict 30- and 90-day mortality in retrospective study
- AI applications in acute care showed potential but face significant implementation challenges
- Red blood cell parameters predict sepsis in children with ALL and chemotherapy-induced neutropenia
- Macrophage glycolysis interactions modulate inflammation and polarization in sepsis
- Genomic analysis shows clonal Campylobacter persistence and gentamicin resistance in two CVID patients
- NTIS subtypes and thyroid antibodies associated with higher in-hospital mortality in sepsis cohort
- Higher Red Cell Distribution Width to Albumin Ratio (RAR) associated with increased mortality in pulmonary sepsis
- Meta-analysis identifies clinical signs associated with sepsis and mortality in young infants
- Socioeconomic factors associated with increased mortality in adults with sepsis or septic shock
- Report describes sepsis program activities in US acute care hospitals
- Meta-analysis finds diaphragmatic atrophy and weakness in critically ill patients on ventilation or with sepsis
- Extracellular histones drive thrombo-inflammation in sepsis, stroke, and ARDS, review finds
- Systematic review explores pathogenesis and emerging treatments for sepsis-induced cardiomyopathy
- Higher baseline chondroitin sulfate predicts greater mortality benefit from restrictive fluid strategy in sepsis
- VR and in-person sepsis simulation show similar skill outcomes in medical student pilot study
- Serum procalcitonin shows moderate accuracy for sepsis diagnosis in critically ill ICU patients
- Procalcitonin-guided antibiotic protocols reduce therapy duration in critically ill sepsis patients
- PAC use in cardiogenic shock associated with lower mortality but higher sepsis risk in meta-analysis
- Case report describes management of Burkitt's lymphoma with concurrent HIV, CMV encephalitis, and salmonella bacteremia