Active sepsis prevention program reduces maternal infection-related complications in Malawi and Uganda
New program cuts deadly infections in mothers by 32%
This cluster-randomized trial in Malawi and Uganda involving 431,394 women found that an Active Prevention and Treatment of Maternal Sepsis …
A low-cost hospital program in Africa cut life-threatening infections in pregnant women by more than 30%, offering hope for safer childbirth…
Sarcopenia in older patients with sepsis is associated with specific plasma metabolomic changes
Metabolic changes link muscle loss to sepsis in older adults
In this prospective observational cohort study of 84 older patients with sepsis, researchers identified significant differences in plasma me…
New findings show how specific chemical changes in the blood connect muscle wasting to severe infections in older patients.
Systematic review identifies dual role of NLRP3 inflammasome in sepsis induced immune dysregulation
NLRP3 activation plays a dual role in sepsis
This systematic review examines the role of NLRP3 inflammasome activation and modulation in sepsis. The authors synthesize evidence showing …
A review of research shows that a specific protein complex helps drive both inflammation and immune suppression during sepsis.
Large language models show varying accuracy for data extraction in sepsis guidelines
AI models show promise for extracting sepsis study data
This study evaluated the performance of large language models, including ChatGPT-4o, Claude 3 Sonnet, and Gemini 1.5 Pro, for data extractio…
New tests show AI can help pull patient details from medical papers, but extracting clinical results remains a major challenge.
Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes
Sepsis Risk Skyrockets When You Have Multiple Chronic Conditions
This narrative review synthesizes evidence regarding sepsis in patients with multimorbidity including type 2 diabetes and heart failure. Aut…
Common chronic diseases like diabetes and heart failure create hidden traps that make sepsis much harder to fight and treat.
Narrative review of Dachengqi Decoction for sepsis-induced organ injury
Dachengqi Decoction may protect organs during dangerous sepsis attacks
This narrative review summarizes evidence that Dachengqi Decoction (DCQD) and its bioactive metabolites may protect against sepsis-induced i…
A traditional Chinese medicine formula shows promise for stopping organ damage in sepsis patients by calming the body's extreme immune react…
Early enteral nutrition linked to favorable biomarker trajectories and lower mortality risk in adult ICU sepsis patients.
Early feeding helps sick patients avoid dangerous metabolic spikes.
This retrospective cohort study of 3,354 adult ICU patients with sepsis at West China Hospital examined early enteral nutrition (EEN). EEN w…
Starting food early in the ICU helps patients avoid dangerous metabolic spikes and lowers the risk of dying within 28 days.
Serum N-myc and STAT interactor (NMI) levels predict 30-day mortality and septic shock in adult sepsis patients.
New Blood Marker Spots Deadly Sepsis Early
This cohort study of 399 adult patients diagnosed with sepsis evaluated serum N-myc and STAT interactor (NMI) concentrations. Higher NMI lev…
A newly studied blood protein can spot which sepsis patients are most at risk — long before their condition crashes.
Narrative review discusses natural bioactive compounds in sepsis with noted pharmacokinetic and safety limitations.
Natural compounds may protect organs in sepsis, but delivery remains a major hurdle.
This narrative review examines natural bioactive compounds, including flavonoids, terpenoids, alkaloids, and quinones, regarding their poten…
A review suggests natural chemicals could shield vital organs during sepsis, yet getting them into the body safely is the real challenge.
Elevated pre-sepsis vitamin B12 levels associated with increased 90-day mortality in adults with sepsis.
High Vitamin B12 Before Sepsis Linked to Higher Death Risk
This retrospective cohort study analyzed 37,660 adults diagnosed with sepsis using the TriNetX database. After propensity score matching, pa…
If your vitamin B12 level is high before you get sepsis, your risk of dying from it may be significantly higher.
Gut Microbiota Dysbiosis Linked to Sepsis in Infants and Young Children With Severe Pneumonia
Gut Bacteria May Predict Sepsis in Sick Babies
This prospective, 1:1 matched case-control study included 100 infants and young children (28 days–36 months) in the PICU. Results showed sig…
A 6-month-old baby fights to breathe in a hospital bed.
Dataset describes continuous monitoring in premature VLBW infants across four US NICUs
Heart rate and oxygen data tracked in premature infants
This dataset description covers continuous heart rate and oxygen saturation monitoring in 3,829 premature very low birth weight infants acro…
A new dataset tracks continuous heart rate and oxygen levels in 3,829 premature infants to improve care.