N/A
N=87
Effectiveness of Opiate Replacement Therapy Administered Prior to Release From a Correctional Facility - 1
HIV Prevention · Opioid-Related Disorders
Bottom Line
View on ClinicalTrials.gov: NCT00142935 ↗Enrolled (actual)
87
Serious AEs
3.5%
Results posted
Jun 2014
Primary outcome: Primary: Treatment Engagement — 23; 11; 6 participants — p=<0.001
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Pre-release Initiation of MMT (Behavioral); Post Release Initiation of MMT. (Behavioral); Standard of Care Plus (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- The Miriam Hospital
- Primary completion
- Dec 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Treatment Engagement |
23; 11; 6 | <0.001 sig |
| PRIMARY Time to MMT Initiation Post Release Based on Clinic Chart Review |
2; 9; 5 | .02 sig |
| PRIMARY HIV Risk Behaviors - Self Report |
3; 6; 8 | .09 |
| SECONDARY Drug Use |
6; 8; 11 | .09 |
| SECONDARY Fatal Overdose |
0; 1; 1 | — |
| SECONDARY Non-fatal Overdose |
3; 3; 2 | 0.8 |
Summary
Much of the HIV/AIDS epidemic is driven by transmission from or to persons addicted to opiates. Many of these individuals pass through a correctional setting each year, creating an opportunity for linkage to substance abuse treatment. The purpose of this study was to evaluate the effectiveness of initiating opiate replacement therapy prior to release from incarceration on reducing HIV risk behaviors and drug relapse. In addition, this study evaluated the effectiveness of short-term payment versus non-payment of community opiate replacement therapy immediately following release from incarceration.
Eligibility Criteria
Inclusion Criteria
- Currently incarcerated at the Rhode Island Department of Corrections with a scheduled release date at least 28 days after enrollment
- Incarceration length not to have exceeded two years at the time of enrollment
- Heroin dependent with self-reported heroin injection in the month prior to incarceration OR enrollment in a methadone treatment program prior to incarceration for heroin addiction with a history of injection drug use
- Desire to enter methadone treatment upon release and plans to secure funding for methadone treatment after study completion
- History of prior tolerance to methadone
- History of at least one drug-related incarceration
- Speaks English or Spanish
- Plans to remain in Rhode Island for the duration of the study (24 months)
- Ability to provide at least two names of individuals who can verify participant information
Exclusion Criteria
- Currently receiving methadone at the Rhode Island Department of Corrections
- Currently undergoing a non-narcotic detoxification from illicit opiates at the Rhode Island Department of Corrections
- Plans to leave Rhode Island within the two years following enrollment
Data sourced from ClinicalTrials.gov (NCT00142935). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.