N/A
Completed N=141
Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients
Pulmonary Disease, Chronic Obstructive · Depression
Source: ClinicalTrials.gov NCT00151372 ↗
Enrolled (actual)
141
Serious AEs
59.6%
Results posted
Jan 2010
Primary outcomePrimary: Composite Antidepressant Score Scale (CAD) — 29; 25; 9; 20 Participants
Summary
Approximately 20% of patients with chronic obstructive pulmonary disease (COPD) have major depression, a condition that contributes to suffering but also to poor treatment adherence leading to increased disability and morbidity. This study investigates the effectiveness of a care management intervention aimed at facilitating adherence to a treatment algorithm based on the Agency for Health Care Policy and Research (AHCPR) guidelines. The investigators hypothesize that this intervention, in comparison to usual care, will increase the prescription of adequate antidepressant treatment by physicians, enhance treatment adherence by patients, and reduce depressive symptoms, suicide ideation, and disability at a 28-week follow-up period.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Composite Antidepressant Score Scale (CAD) |
29; 25; 9; 20 | — |
| SECONDARY Hamilton Depression Rating Scale |
9.2; 12.4 | — |
Eligibility Criteria
Inclusion Criteria
- Chronic obstructive pulmonary disease by American Thoracic Society criteria
- Major depression by DSM-IV criteria
- 17-item Hamilton score >14
- English speaking
Exclusion Criteria
- Inability to give informed consent
- MiniMental score <24
- Aphasia
- Nursing home placement after discharge
Data sourced from ClinicalTrials.gov (NCT00151372). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.