N/A
N=141
Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients
Pulmonary Disease, Chronic Obstructive · Major Depression
Bottom Line
View on ClinicalTrials.gov: NCT00151372 ↗Enrolled (actual)
141
Serious AEs
59.6%
Results posted
Jan 2010
Primary outcome: Primary: Composite Antidepressant Score Scale (CAD) — 29; 25; 9; 20 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Treatment Adherence Intervention (Behavioral); Enhanced Care (Behavioral)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- Weill Medical College of Cornell University
- Primary completion
- Jul 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Composite Antidepressant Score Scale (CAD) |
29; 25; 9; 20 | — |
| SECONDARY Hamilton Depression Rating Scale |
9.2; 12.4 | — |
Summary
Approximately 20% of patients with chronic obstructive pulmonary disease (COPD) have major depression, a condition that contributes to suffering but also to poor treatment adherence leading to increased disability and morbidity. This study investigates the effectiveness of a care management intervention aimed at facilitating adherence to a treatment algorithm based on the Agency for Health Care Policy and Research (AHCPR) guidelines. The investigators hypothesize that this intervention, in comparison to usual care, will increase the prescription of adequate antidepressant treatment by physicians, enhance treatment adherence by patients, and reduce depressive symptoms, suicide ideation, and disability at a 28-week follow-up period.
Eligibility Criteria
Inclusion Criteria
- Chronic obstructive pulmonary disease by American Thoracic Society criteria
- Major depression by DSM-IV criteria
- 17-item Hamilton score >14
- English speaking
Exclusion Criteria
- Inability to give informed consent
- MiniMental score <24
- Aphasia
- Nursing home placement after discharge
Data sourced from ClinicalTrials.gov (NCT00151372). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.