Moderate-intensity exercise reduces negative attentional bias in anxiety and depression compared to high-intensity exercise
Moderate Exercise May Help Reduce Negative Thoughts in Anxiety
This meta-analysis of 32 studies examined the impact of physical exercise on attentional bias in individuals with anxiety, depression, and a…
Moderate-intensity exercise may help reduce negative focus for people with anxiety or depression while helping to lower cravings for addicti…
Exercise-based and mind-body movement interventions significantly reduce depressive symptoms in patients with inflammatory bowel disease
Mind-Body Movement May Reduce Depression in Inflammatory Bowel Disease
This meta-analysis of randomized controlled trials indicates that exercise-based and mind-body movement interventions significantly reduce d…
New research suggests that exercise and mind-body movements can significantly lower depressive symptoms for people living with inflammatory …
Preliminary evidence suggests therapeutic drug monitoring of sertraline may guide clinical judgment in specific populations
TDM Monitoring May Help Guide Sertraline Use for OCD Patients
This scoping review examined the clinical utility of sertraline therapeutic drug monitoring (TDM) for individuals with depression and obsess…
Monitoring blood levels of the medication sertraline might help doctors manage treatment for patients with depression and obsessive-compulsi…
Art therapy associated with moderate reduction in depressive symptoms across 19 studies
Art Therapy Linked to Reduced Depression Symptoms
This meta-analysis of 19 studies (997 patients) found that art therapy is associated with a moderate reduction in depressive symptoms (Hedge…
A new analysis of 19 studies finds art therapy may help ease depression symptoms.
SSRIs show significant reduction in depressive symptoms only when used for 6 months or longer
SSRIs May Help Depression in Patients with Diabetes Over Time
This systematic review and meta-analysis of 9 RCTs involving 770 participants found that SSRIs significantly reduced HDRS scores only in pat…
SSRIs may help manage depression symptoms in people with diabetes, but only when used for at least six months.
Visual art therapy significantly reduces depressive and anxiety symptoms in adults
Visual art therapy eases depression and anxiety in adults
This meta-analysis of 741 adults found that visual art therapy significantly alleviated depressive symptoms (SMD = -0.81) and anxiety sympto…
A new analysis of 741 adults finds that visual art therapy significantly reduces depression and anxiety symptoms.
Third-wave therapies significantly reduce post-stroke depression symptoms with sustained mid- to long-term effects
Third-wave therapies show promise for post-stroke depression symptoms
This systematic review and network meta-analysis of 3106 patients found that third-wave therapies significantly improved post-stroke depress…
New analysis suggests third-wave psychological therapies can significantly reduce depression symptoms in stroke survivors over the long term…
Serotonergic antidepressants and prolactin-elevating antipsychotics are associated with higher burdens of sexual dysfunction
Certain medications for depression and psychosis can cause sexual issues
This narrative review examines the impact of antidepressants and antipsychotics on sexual dysfunction in patients with depressive and psycho…
Some common treatments for mood and psychotic disorders may impact a patient's sex life, quality of life, and their ability to stay on medic…
Animal-assisted therapy reduces depression, anxiety, and stress in adults with moderate-to-large effects
Animal assisted therapy reduces anxiety, depression and stress in adults
This meta-analysis of 2391 adults found that animal-assisted therapy (AAT) significantly reduces depression, anxiety, and stress at post-int…
Interacting with animals can significantly lower feelings of anxiety, depression, and stress for adults regardless of their age or gender.
Habitual Mindfulness Practice reduces depressive and anxiety symptoms in adults with mild to moderate distress
Mobile mindfulness practice helps reduce anxiety and depression symptoms
This randomized controlled trial of 686 adults found that Habitual Mindfulness Practice (HMP) significantly reduced depressive and anxiety s…
A new mobile app approach to mindfulness shows promise for adults struggling with mild to moderate anxiety or depression.
Exercise-induced lactate via the lactate-HCAR1 axis serves as a potential immunometabolic mechanism in depression
Exercise Lactate May Offer New Path for Treating Depression
This narrative review explores the lactate-HCAR1 axis as a link between exercise metabolism and inflammatory responses in depression. The au…
New research explores how the lactate produced during exercise might help regulate inflammation and brain responses in people with depressio…
Transcutaneous Vagus Nerve Stimulation utilizes distinct auricular and cervical pathways for non-invasive treatment applications
Two different ways to stimulate the vagus nerve for treatment
This narrative review examines the anatomical access points and methodologies for transcutaneous Vagus Nerve Stimulation (tVNS). It distingu…
New research highlights two distinct paths for non-invasive nerve stimulation to treat conditions like migraine and depression.
Questions about Depression
Do patients with perinatal depression show brain alterations compared to healthy controls?
Research shows that women with perinatal depression have measurable brain changes compared to healthy controls, including reduced activity in regulatory areas and increased activity in emotional centers.
Full answer →What is the prevalence of perinatal depression among women in Ethiopia?
Perinatal depression affects 20.1% to 25.8% of women in Ethiopia based on pooled meta-analysis, with individual studies reporting rates up to 32.2%.
Full answer →Is there a link between polygenic risk scores and major depression with anxiety?
Yes, polygenic risk scores for major depression show stronger associations with comorbid anxiety-depression cases than with depression alone, indicating a shared genetic link.
Full answer →How do technical and behavioral factors affect blood biomarker results for depression?
Technical factors (e.g., blood collection time, season) and behavioral factors (e.g., BMI, smoking, exercise) can significantly influence blood biomarker levels, potentially affecting depression-related results.
Full answer →Are there specific blood biomarkers that predict major depression outcomes in UK Biobank?
No specific blood biomarkers have been validated to predict major depression outcomes in UK Biobank; research is ongoing.
Full answer →Can psychedelic-assisted therapy be an effective treatment option for my major depression?
A 2024 systematic review found that psychedelic-assisted therapy does not show a clear advantage over traditional antidepressants for treating major depression when both are compared in open-label trials.
Full answer →Does aerobic exercise reduce postpartum depressive symptoms and improve quality of life?
Yes, multiple meta-analyses show aerobic exercise significantly reduces postpartum depressive symptoms and improves quality of life, with moderate to large effect sizes.
Full answer →Is Zurzuvae approved by the FDA for treating postpartum depression in adults?
Yes, the FDA approved Zurzuvae (zuranolone) on August 4, 2023, for treating postpartum depression in adults.
Full answer →All Depression Articles
- Moderate-intensity exercise reduces negative attentional bias in anxiety and depression compared to high-intensity exercise
- Exercise-based and mind-body movement interventions significantly reduce depressive symptoms in patients with inflammatory bowel disease
- Preliminary evidence suggests therapeutic drug monitoring of sertraline may guide clinical judgment in specific populations
- Art therapy associated with moderate reduction in depressive symptoms across 19 studies
- SSRIs show significant reduction in depressive symptoms only when used for 6 months or longer
- Visual art therapy significantly reduces depressive and anxiety symptoms in adults
- Third-wave therapies significantly reduce post-stroke depression symptoms with sustained mid- to long-term effects
- Serotonergic antidepressants and prolactin-elevating antipsychotics are associated with higher burdens of sexual dysfunction
- Animal-assisted therapy reduces depression, anxiety, and stress in adults with moderate-to-large effects
- Habitual Mindfulness Practice reduces depressive and anxiety symptoms in adults with mild to moderate distress
- Exercise-induced lactate via the lactate-HCAR1 axis serves as a potential immunometabolic mechanism in depression
- Transcutaneous Vagus Nerve Stimulation utilizes distinct auricular and cervical pathways for non-invasive treatment applications
- AI tools offer high accessibility for mental health support but face significant cultural and linguistic barriers
- Ecological momentary interventions reduce depressive symptoms with moderate effect in meta-analysis
- Meta Analysis Quantifies Prevalence and Risk Factors of Depressive Disorders in HIV Patients
- Evaluating the Efficacy of Accelerated Transcranial Magnetic Stimulation for Suicidal Ideation
- New 27-item screening tool developed for mental disorders in Indonesian prisons
- Mindfulness-based cognitive therapy improves depressive symptoms through decentering mediation in adults
- Dietary interventions may influence obesity and depressive symptoms through multiple metabolic and neurological pathways
- Hormonal contraceptive types influence mood outcomes with progestin-only methods showing higher risks for mood disorders
- Moderate-intensity exercise ranked best for reducing internet addiction, depression, anxiety
- Repetitive transcranial magnetic stimulation addresses various mental disorders including depression, bipolar disorder, and schizophrenia
- Tai Chi significantly reduces depression symptoms among college students with an SMD of -0.67
- Aerobic exercise reduces subthreshold depressive symptoms in adolescents compared to psychoeducation
- Esketamine reduces 3-month postpartum depression incidence from 20.89% to 11.59% in primiparae
- Intranasal esketamine provides rapid acute improvement and reduced relapse risk in treatment-resistant depression
- Self-referential processing patterns linked to depression and anxiety, moderated by sample and methods
- Mobile-based cognitive behavioural therapy apps significantly reduce depressive symptoms in adolescents and young adults
- Oral ketamine significantly reduces depression scores with a 2.38 relative risk for remission
- Portable Digital Nature Experience significantly reduces stress, anxiety, and depression scores
- Exercise interventions significantly improve sleep quality in patients with depression across 19 RCT comparisons
- Esketamine bolus reduces PPD incidence at 6 weeks to 9.15% compared to 19.33% in saline
- Multidimensional factors including loneliness and ageism contribute to death wishes in older adults
- Naringenin shows strong antidepressant-like effects in rat meta-analysis
- Depression prevalence reaches 50.9% among patients with advanced cancer receiving palliative care
- Air pollution exposure is associated with increased risk of depression and postpartum depression
- Mental health screening tools show varying diagnostic accuracy for adolescent depression in sub-Saharan Africa
- Reducing social media use to 1 hour daily significantly reduces loneliness in youth
- GLP-1R exposure shows no causal link to most mental disorders except eating disorders
- Open psychiatric wards improve depression scores and treatment adherence in hospitalized patients with depression
- Esketamine significantly reduces postoperative anxiety (SMD -1.23) and depressive symptoms (SMD -0.92) in adult patients
- Yoga with education yields clinically relevant improvements for depressive symptoms and pain in chronic low back pain
- Dance and Tai Chi rank highest for depression and anxiety in non-pharmacological interventions
- Structured exercise modalities significantly reduce depressive symptoms and anxiety in adults with large effect sizes
- Eco-anxiety shows moderate positive association with depression, anxiety, and stress in young adults
- 12-week yoga therapy versus brisk walking improved anxiety and depression in HIV patients on antiretroviral therapy.
- Younger US men show sharp loneliness increase, older men stable, systematic review finds
- Brief social media breaks may ease stress and boost well-being in college youth
- Primary care-based intensive psychotherapy cuts inpatient costs over $8,000 per Karen refugee patient
- Universal digital mental health interventions show significant overall effects for anxiety and depression in children and adolescents
- Plant-derived compounds show potential for substance use disorders, depression, anxiety
- Gut microbiota alterations linked to anxiety and depression in inflammatory bowel disease patients
- Higher EAT-Lancet diet adherence linked to lower risks of depression, anxiety, stroke, and dementia in observational cohorts
- Arts on Prescription programmes show statistically significant but clinically modest reductions in depression and anxiety among adults
- Mental Health Literacy Curriculum Improves Outcomes in Chinese College Students
- Internet-based CBT modestly reduces anxiety and depression in breast cancer survivors
- Gut microbiome dysbiosis links to depression across distinct thematic domains in computational meta-analysis
- Persistent depressive trajectory affects 9% of adult perinatal women with increased risk factors
- Machine learning models show moderate predictive accuracy for CBT depression outcomes in external validation
- Art therapy reduces depressive symptoms significantly in adults with depression compared with control conditions
- Interventions reduce mental health symptoms in people affected by extreme weather events across multiple studies
- Atractylenolide III shows neuroprotective effects in preclinical CNS disorder models
- Structured exercise cuts depression, anxiety, and stress in university students with large to moderate effects
- Meta-analysis finds esketamine improves response in treatment-resistant depression with dose-dependent adverse events
- Narrative review on atrial fibrillation and depression highlights bidirectional links and integrated care needs
- Review of microbiota-informed approaches for adolescent depression notes limited causal evidence
- Depression screening predicts lower health-related quality of life in ICU survivors
- Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
- Meta-analysis and preclinical study link Limosilactobacillus fermentum to depression
- Motherly app shows stronger depressive symptom reduction in women with fewer children and higher pediatric consultations
- Depression linked to higher risk of progression from mild cognitive impairment to Alzheimer's disease and dementia in adults
- Systematic review and meta-analysis of MDMA-assisted therapy for trauma and depression
- Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents
- Mind-body therapies reduce depression and anxiety in people with cancer, network meta-analysis finds
- Meta-analysis review links anxiety and depression to reduced cognitive flexibility and decision-making
- Yoga reduces depression in breast cancer patients across multiple treatment groups
- Systematic review and meta-analysis links intolerance of uncertainty to depression in children and adolescents
- Systematic review and meta-analysis of intranasal esketamine for treatment-resistant depression in real-world settings
- Narrative review examines exercise effects on anxiety, depression, and metabolic dysfunction without reported outcomes
- Meta-analysis of psychosocial interventions for older adults with subclinical depression and anxiety
- Network meta-analysis of non-pharmacological interventions for subthreshold depression in youth
- Exposure to T gondii linked to small psychiatric risks but causality remains uncertain in current reviews
- Meta-analysis links high homocysteine levels to worse cognitive scores in depression patients
- Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
- Psychological interventions significantly reduce anxiety and depression in cancer pain patients compared to conventional care
- Review of observational cohort links ACS cancer prevention guidelines to lower depression and anxiety symptoms
- CBT Chatbots Show Moderate Depression Relief But High Bias Limits Confidence In Anxiety Findings
- Systematic review and meta-analysis of mindfulness for post-stroke depression
- Multimodal stepped-prevention program fails to reduce suicidal thoughts in adolescents
- Systematic review finds no efficacy advantage for psychedelic-assisted therapy over traditional antidepressants in major depression
- Genotype-Guided SSRI Prescribing Shows No Short-Term Benefit but Higher Remission at 6 Months
- Maintenance antidepressants show no effect on happy face recognition in adults with recurrent depression
- Meta-analysis synthesizes evidence on cognitive triad and depressive symptoms
- Network meta-analysis reveals mind-body and combined exercise modalities significantly improve depressive and anxiety symptoms in cancer patients
- Meta-analysis finds high anxiety and depression prevalence in pediatric inflammatory bowel disease
- Frailty is associated with increased prevalence of depressive symptoms in adults with cancer
- Digital single session reappraisal intervention affects social media interpretation bias in college students
- Preoperative Pain Education Reduces Postoperative Pain and Postpartum Depression After Cesarean
- Auricular Acupressure With Music Therapy Reduces Labor Pain and Postpartum Depression
- Intranasal naloxone reverses opioid-induced respiratory depression in opioid-naive and daily users within 2 to 17 minutes
- Systematic review shows regional differences in HS comorbidity prevalence across North America, Europe, and Asia
- Naltrexone-Bupropion Aids Weight Loss in Overweight Adults With Depression
- Self-help mindfulness and CBT interventions reduce depression and anxiety in distressed students
- Digital mental health intervention reduces anxiety and depression in Chinese high school students
- Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
- Meta-analysis finds NLRP3 inflammasome components upregulated in animal depression models
- Systematic review and meta-analysis of digital technology interventions for cognitive function and mood in older adults
- Sex differences in genetic correlation between ischaemic heart disease and depression found in 1.14 million European ancestry individuals
- Narrative review discusses pharmacological and lifestyle interventions for type 2 diabetes and psychological health
- Mirtazapine and olanzapine reduce anxiety and depression scores in oral cavity cancer patients
- Review of miRNA associations with high-risk diabetes profiles in midlife women
- Narrative review explores microbiome mechanisms as a promising adjunctive avenue for managing depression, anxiety, bipolar disorder, and schizophrenia
- Electroacupuncture research trends for depression show shifting focus to mechanisms from 2005 to 2025
- Non-Randomized Pilot Trial Evaluates Aurora Digital CBT Plus Medication for Generalized Anxiety Disorder
- Psychomotor retardation in depression linked to increased Parkinson's risk
- Executive function training reduces anxiety and depression in working adults, CBT app improves workplace well-being
- Perinatal depression prevalence in Ethiopian women ranges from 20.1% to 25.8% based on pooled meta-analysis data
- Fatigue and depression severity correlation in survivors of severe prolonged COVID-19
- Meta-analysis shows altered resting-state functional activity in postpartum depression brain regions
- Meta-analysis of voice acoustic parameters in depression finds nonsignificant frequency difference
- MDD polygenic scores show adolescence-specific effects on child depressive symptoms in Norwegian cohort
- Protocol for COMPASS CBT pilot trial in forcibly displaced Venezuelan adults in Peru
- Observational Study Links Latitude and Genetics to Seasonal Affective Disorder Risk in Adults
- Meta-analysis finds prenatal psychological interventions reduce postpartum depression incidence
- Sodium oxybate and other drugs flagged for perinatal depression risk in pharmacovigilance analysis
- FDA Approves Zurzuvae (zuranolone) for Postpartum Depression in Adults
- Systematic review of Traditional Chinese Medicine for depression with unreported outcomes and safety data
- Prenatal parabens exposure linked to adverse pregnancy outcomes in mothers with depressive symptoms in Ningxia, China
- Systematic review and meta-analysis shows exercise improves depression and quality of life in hemodialysis patients
- Scoping review of mental health in sub-Saharan African university students during COVID-19
- Meta-analysis finds aerobic exercise reduces postpartum depressive symptoms and improves quality of life
- Review of P-NQLS psychometric validation in U.S. parents of children aged 6-18 years
- Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
- SCC DBS with at-home LFP data collection predicts stable recovery in treatment-resistant depression
- Lifetime violence exposure linked to psychiatric outcomes in South African children
- Intensive Short-Term Dynamic Psychotherapy showed large effects on depression in treatment-resistant depression patients
- High-frequency music therapy reduces stress in adult psychiatric inpatients compared to low-frequency sessions
- Systematic review and meta-analysis of CBT for depression in multiple sclerosis patients
- Meta-analysis on psychological interventions and early psychosis care for depression and psychosis
- Observational cohort links symptom severity subgroups to poorer functioning and brain volume in psychosis and depression risk
- Protocol for Randomized Clinical Trial of Acupuncture Versus Sham Acupuncture in Irritable Bowel Syndrome
- Elobixibat improved constipation in schizophrenia or depression patients during postmarketing surveillance in Japan
- Bayesian network meta-analysis of exercise interventions for depression and anxiety in cancer survivors
- Narrative review of TRD epidemiology and CYP2C19 genotypes in Pakistan
- Case-control study links impaired decision-making tasks to suicide attempts in depressed patients
- Polygenic risk scores show stronger associations with comorbid anxiety and depression cases in cohort studies
- Systematic review and meta-analysis on depression and anxiety prevalence in liver cirrhosis
- Narrative review links ceramide elevations to major depressive disorder and suicidal vulnerability
- Narrative review explores psychobiotics and lifestyle changes for chronic constipation-depression comorbidity
- Meta-analysis links diabetic retinopathy with anxiety and depression in over 383,000 patients
- FDA Approves Spravato (esketamine) for Treatment-Resistant Depression and Depressive Symptoms with Acute Suicidal Ideation in Adults
- Pilot RCT in veterans with depression finds no benefit from immediate PGx testing
- PRISM implementation support increased depression care pathway adoption in obstetric practices compared to standard care
- Home-based cardiac rehab yields greater mental health and HRQoL gains in heart failure patients with elevated depression
- Meta-analysis finds machine learning models predict depression in diabetes with AUC 0.822
- Systematic review finds exercise prescription linked to mood, cognition, and stress resilience benefits
- Ten-week Baduanjin exercise improved sleep and mood in college students with Qi-deficiency constitution
- GP psychoeducation sessions show no significant effect on depressive symptoms in primary care patients
- Omega-3 supplementation reduces stress, anxiety, and depression in Saudi adults over three months
- Meta-analysis shows psychotherapy effect sizes vary by baseline depression severity compared to control conditions
- Women at high risk for postpartum depression prefer psychiatric clinics with low costs and short waits
- Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort
- Pharmacogenomic-guided treatment showed age-dependent cognitive benefits in depressive disorder patients
- Anti-inflammatory diets show mental health benefits in adults, with most consistent improvements in depressive symptoms
- Self-reported racial discrimination associated with postpartum depression and low birth weight in pregnant women
- Mini-review examines natural product compounds in rodent depression models
- Chronic pain linked to 7.5-fold increase in severe depressive symptoms in UK Biobank analysis
- Narrative review examines depression-dementia relationship in aging populations
- Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV
- High-frequency rTMS plus exercise reduced craving and negative emotions in methamphetamine use disorder
- Frailty shows strong positive association with depression in older adults with coronary heart disease
- Phase 2 RCT finds AI-coached therapy improves depression and anxiety symptoms versus waitlist
- Cross-sectional study finds brain structure alterations in chronic pain and depression
- My Cosmos preliminary evaluation shows positive usability and acceptance among university students and mental health professionals
- Group singing intervention improves maternal communication and perceived attachment in postnatal depression
- Ten-session school-based mental health package reduces depressive and anxiety symptoms in Chinese adolescents compared to routine curriculum
- Digital journaling shows modest anxiety reduction in young adults with mild-to-moderate symptoms
- Meta-analysis finds emotional abuse most strongly linked to depression among child maltreatment forms
- Meta-analysis finds 23% subthreshold depression prevalence in patients with diabetes mellitus
- PCSK9 inhibitor initiation associated with lower depression risk versus statins in hyperlipidemia
- Prenatal depression screening uptake increased but diverged across language groups from 2019 to 2024
- AI CBT chatbot access reduces anxiety and depression symptoms in Brazilian primary care patients
- TAO-TMS shows high response rates in a small naturalistic Asian treatment-resistant depression cohort compared to historical controls
- Cognitive-behavioral and interpersonal programs reduce depression and anxiety symptoms in adolescents
- Breathwork reduces anxiety, depression, and stress in paramedic students in 12-week RCT
- Diary intervention improves sleep and reduces stress in critically ill children and their parents
- Internet-based IPM+ intervention reduces depressive symptoms in pregnant women with antenatal depression
- Social isolation linked to health risks in empty-nest older adults, integrative review finds
- Mindfulness-Based Art Therapy and Stress Reduction Show Benefits for Oncology Nurses in RCT
- Serenity therapy reduces symptoms and improves coping in geriatric hemodialysis patients
- Meta-analysis finds moderate negative correlation between meaning in life and depression
- Observational study examines antidepressant use patterns by sex and marital status in US adults
- Ketogenic diet shows modest antidepressant benefit at 6 weeks in adults with treatment-resistant depression
- Observational study examines breakfast consumption and academic, mental health outcomes in US high school students
- AI visual psychophysiological analysis shows high sensitivity for depression screening in 98 outpatients
- P50 sensory gating deficits linked to depressive symptoms in adolescents with non-suicidal self-injury
- Vitamin D deficiency associated with depression in adolescents and young adults, stronger in females
- Meta-analysis finds depression associated with elevated Parkinson's disease risk
- Discordant multimorbidity linked to poorer health status and higher healthcare use in Chinese adults
- Hypnotic cognitive therapy reduces pain intensity in adults with spinal cord injury