N/A
Completed N=61
Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly?
Source: ClinicalTrials.gov NCT00159588 ↗Enrolled (actual)
61
Serious AEs
0.0%
Results posted
Dec 2021
Primary outcomePrimary: Headache Days — 7.2; 4.2; 1.6 days/month — p=0.056
Summary
It is a common belief that patients with MOH rarely respond of preventative medications whilst overusing acute medications. However, no randomized trial has been done previously to prove such statement. Based on some clinical experiences, our hypothesis are patients with probably MOH may benefit from use of preventive medications better than treatment with abrupt withdrawal or no specific treatment.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Headache Days |
7.2; 4.2; 1.6 | 0.056 |
| SECONDARY Headache Index |
169; 371; 302 | 0.012 sig |
Eligibility Criteria
Inclusion Criteria
- fulfill 8.2.7 probably medication-overuse headache according to the International Classification of Headache Disorders, 2th Edition (2004)
Exclusion Criteria
- No benefit of all available preventative medications
- no benefit of abrupt withdrawal lasting more than 3 weeks of acute medication that has been overused
- cluster headache
- chronic paroxysmal hemicrania
- hemicrania continua, pregnancy
- use of pain killers for other reasons than headache
- other reasons for chronic daily headache than medication-overuse
Data sourced from ClinicalTrials.gov (NCT00159588). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.