N/A N=309 Prospective ED Headache Cohort Study
Headache
Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=205 Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines
Migraine
Primary: Persistent Headache Pain Free at 24 Hours — 26; 19 Participants
N/A N=23 Intracranial Pressure in Experimental Models of Headache
High Altitude Headache
Primary: Change in Optic Nerve Sheath Diameter by Ultrasonography — 0.02; 0.02 mm — p=0.98
Phase 4 N=5 An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache
Pain
Primary: Change in Pain Score at 60 Minutes — 4; 5 score on a scale
Phase 3 N=160 Metoclopramide for Post Traumatic Headache
Post-Traumatic Headache
Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale
N/A N=459 A Retrospective Chart Review to Evaluate Diagnosis and Treatment of Chronic Migraine and Headache
Migraine Disorders · Headache
Primary: Presence or Absence of Prophylactic Medication for Headache/Migraine — 166; 227; 18; 48 Participants
N/A N=70 A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.
Headache
Primary: Number of Participants With Adequate Relief of Headache as a Measure of Efficacy — 34; 32 Participants — p=0.14
Phase 4 N=122 Olanzapine for Acute Headaches
Headache
Primary: Change in Pain Scores Based on Patient Questionnaire — -2.95; -1.79; -4.49; -2.65 units on a scale of 1-10
N/A N=91 Oxygen Therapy for the Treatment of Undifferentiated Headache in the Emergency Department
Headache
Primary: Time to Relief (Min) — 92.2; 83.9; 35.4 Minutes
N/A N=102 A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache.
Cluster Headache
Primary: Comparison of the Headache Pain Free Attack Rates at 15 Minutes Following the Treatment — 495; 400; 67; 46 Number of attacks
Phase 4 N=58 Intravenous Fluids in Benign Headaches Trial
Headache
Primary: Reduction in Pain Scores at 60 Minutes — 48.7; 48.3 reduction in visual analog pain score
Phase 2 N=21 Metoclopramide for Post-Traumatic Headache. A Pilot Study
Post-Traumatic Headache
Primary: Number of Participants With Sustained Headache Relief — 12 Participants
Phase 4 N=123 Metoclopramide Versus Ketorolac for Tension-type Headache
Headache
Primary: Change in Pain Score — 3.8; 5.1 units on a scale
Phase 4 N=16 Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage
Primary: Average Numeric Pain Score — 5.2; 5.8 score on a scale — p=0.7
Phase 3 N=226 Ibuprofen Sodium Tension Headache Study
Pain
Primary: Time-weighted Sum of Pain Relief Rating and Pain Intensity Difference From 0-3 Hours (SPRID 0-3) for Ibuprofen Sodium Versus Placebo Tablet — 9.6; 3.5 units on scale…
N/A N=193 Cognitive-Behavior Therapy for Posttraumatic Headache
Post-traumatic Headache · PTSD
Primary: Headache-related Disability Scores on the Headache Impact Test 6 (HIT-6) — 66.1; 66.1; 65.2; 61.9 score on a scale — p=<0.001
Phase 4 N=62 Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
Headache · Pregnancy Related · Occipital Nerve Block
Primary: Number of Participants With Response to Occipital Nerve Block in Pregnancy — 20; 16 Participants — p=0.30
Phase 2 N=31 Treatment of Acute Migraine Headache in Children
Migrainous Headache
Primary: The Number of Subjects With a Numeric Rating Scale Score (NRS) of Zero at Two Hours. — 5; 12 participants — p=0.03
N/A N=40 Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache
Chronic Daily Headache
Primary: Reduction in Headache Intensity — 6; 4; 1; 3 Participants
Phase 3 N=200 Study Evaluating A Novel Ibuprofen Formulation In Episodic Tension-Type Headache
Pain
Primary: Time-weighted Sum of Pain Relief Rating and Pain Intensity Difference From 0-3 Hours (SPRID 0-3) for Ibuprofen Sodium Versus Placebo Tablet — 11.2; 10.8 Units on a scale…
N/A N=45 Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?
Chronic Daily Headache
Primary: Number of Subjects With Daily Headache Who Have Continuous Headache — 18; 27 participants
N/A N=494 Postoperative Headache in Elective Surgery Patients
Drug Withdrawal Headache
Primary: Frequency of Postoperative Headache in Elective Surgery Patients — 126; 37; 89 participants
Phase 4 N=162 Dexamethasone for Post Traumatic Headache
Post-Traumatic Headache
Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751
N/A N=48 RELAXaHEAD for Headache Patients (Phase II)
Migraine · Headache · Multiple Sclerosis
Primary: Number of Patients Enrolled in the Study — 24; 24 Participants
Phase 2 N=31 Pilot Study of VVD-101 for the Treatment of Delayed Alcohol-Induced Headaches
Delayed Alcohol Induced Headache
Primary: Headache Severity 2 Hours Post Treatment — 2.18; 2.09; 0.85; 1.17 units on a scale
Phase 4 N=401 Comparing Naproxen to Sumatriptan for Emergency Headache Patients
Migraine · Tension-type Headache · Primary Headache Disorder
Primary: Numerical Rating Scale — 4.1; 4.3 units on a scale
Phase 2 N=50 Amitriptyline to Prevent Headache After Traumatic Brain Injury
Brain Injuries · Post-Traumatic Headache
Primary: Frequency of Headaches — 10 Participants — p=.101
N/A N=759 IndoProCaf Effervescent Tablets Effectiveness in Acute Treatment of Migraine and/or Episodic Tension-type Headache and Patients' Satisfaction With the Treatment in Routine Clinical Practice
Headache Disorders, Primary · Migraine With Aura · Migraine Without Aura
Primary: Percentage of Patients With Significant Pain Reduction — 90.3 percentage of participants
Phase 2 N=40 Sumatriptan as Treatment for Post-traumatic Headache
Post-traumatic Headache
Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079
Phase 2 N=165 Safety and Efficacy Study of TNX-201 Capsules for Treatment of Single Tension-Type Headache
Tension-Type Headache
Primary: Number of Subjects Pain Free — 21; 20; 21; 19 Participants