N/A
N=165
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy
Congenital Heart Disease
Bottom Line
View on ClinicalTrials.gov: NCT00165984 ↗Enrolled (actual)
165
Serious AEs
0.0%
Results posted
May 2012
Primary outcome: Primary: To Evaluate the Incidence of the Pre-proendothelin SNP at Nucleotide 5665 — 10 participants
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Pediatric, Adult, Older Adult
- Sex
- All
- Sponsor
- Emory University
- Primary completion
- Aug 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY To Evaluate the Incidence of the Pre-proendothelin SNP at Nucleotide 5665 |
10 | — |
| PRIMARY Survival |
40; 80; 88 | 0.003 sig |
Summary
There are many kids born with congenital heart disease. Some of these defects may lead to the formation of a single ventricle (the heart having only one pumping chamber). These children normally undergo a series of corrective surgeries to help overcome the problems of having just one ventricle. However there are some differences in how well the patients respond to the surgeries. In the adult population, studies have shown that there may be a genetic link that may be responsible for the differences in how patients respond. The investigators would like to study the pediatric population by looking for certain genetic markers in the patients' blood. They will also collect basic health information on each patient.
Eligibility Criteria
Inclusion Criteria
- Children who currently have functional single ventricle anatomy or have had heart transplantation for single ventricle anatomy who receive their cardiac care at Children's Healthcare of Atlanta, Egleston Hospital.
- Family agrees to participate in the study following informed consent
Exclusion Criteria
- Conversion to two ventricle physiology, excluding transplantation.
Data sourced from ClinicalTrials.gov (NCT00165984). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.