Phase 2
Completed N=39
Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
Source: ClinicalTrials.gov NCT00210158 ↗Enrolled (actual)
39
Serious AEs
0.0%
Results posted
Sep 2025
Primary outcomePrimary: Post-operative Morphine Consumption — 54.6; 44.8 mg — p=0.5
Summary
Peroperative opioids are known to induce N-Methyl-D-Aspartate dependent enhancement of postoperative hyperalgesia. For patients with current opioid treatment, these phenomena could be exagerated and could produce greater postoperative opioid consumption and higher pain score. Since Nitrous oxide has anti- N-Methyl-D-Aspartate properties, the aim of this study was to evaluate, in patients with current opioid treatment, the effects of peroperative Nitous oxide on postoperative opioid consumption and pain score, after vertebroplasty.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Post-operative Morphine Consumption |
54.6; 44.8 | 0.5 |
| SECONDARY Proportion of Participants With Post-operative Pain |
2; 1 | — |
Eligibility Criteria
- Older than 18 years
- Current opioid treatment > 1 month
- patients scheduled to undergo vertebroplasty with general anesthesia
Data sourced from ClinicalTrials.gov (NCT00210158). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.