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Oncology
Meta-analysis
Systematic review of cold vs warm sodium hypochlorite irrigation for postoperative pain in root canal therapy
Cold Rinse Cuts Tooth Pain After Root Canals
This narrative systematic review evaluates postoperative pain in patients undergoing root canal therapy using cold versus warm or room tempe…
A simple change in root canal care—using a cold rinse instead of warm—could reduce pain in the first hours after treatment, offering relief …
Frontiers
Apr 24, 2026
Pediatrics
RCT
Esketamine vs fentanyl for pediatric tonsillectomy pain shows comparable FLACC scores
Esketamine and fentanyl ease kids' tonsil pain equally after surgery
This randomized controlled trial in 54 children scheduled for tonsillectomy compared esketamine 0.5 mg·kg to fentanyl 4 μg·kg at induction. …
For kids getting tonsils out, esketamine and fentanyl control pain just as well, but esketamine keeps blood pressure steadier during surgery…
Apr 23, 2026
Rheumatology
RCT
Oxycodone PCIA reduces visceral pain vs. sufentanil after repeat cesarean section
Better Pain Relief Found for Women After Repeat C-Section
This randomized controlled trial in 100 women undergoing elective repeat cesarean section compared patient-controlled intravenous analgesia …
A new study shows a specific painkiller might work better for women having repeat C-sections.
Frontiers
Apr 23, 2026
Anesthesiology & Pain Medicine
Meta-analysis
Network meta-analysis compares 155 analgesic regimens for pain after knee and hip arthroplasty
Study Compares 155 Pain Relief Methods After Knee and Hip Replacement Surgery
A network meta-analysis of 211 RCTs involving 22,972 patients compared 155 analgesic regimens for postoperative pain after knee or hip arthr…
Patients recovering from knee or hip surgery can find which of 155 pain relief methods best controls pain and improves movement in the first…
Apr 9, 2026
Anesthesiology & Pain Medicine
RCT
Oliceridine PCA non-inferior to sufentanil for knee arthroplasty pain, with lower nausea and vomiting
Oliceridine shows similar pain relief to sufentanil after knee surgery with fewer side effects
A randomized controlled trial in 138 elderly patients undergoing knee arthroplasty found Oliceridine patient-controlled analgesia was non-in…
Oliceridine works as well as sufentanil for knee surgery pain but causes less nausea and vomiting in elderly patients.
Apr 6, 2026
Diabetes & Endocrinology
RCT
Post-thyroidectomy rehabilitation exercise improves swallowing QoL but increases early pain in single-center RCT
Can simple neck exercises help people swallow better after thyroid surgery?
A single-center, open-label RCT of 356 post-thyroidectomy patients without definite nerve injury found that 3 months of standardized neck an…
Simple neck exercises helped people swallow better and enjoy food sooner after thyroid surgery, with benefits lasting six months despite ear…
Apr 4, 2026
Anesthesiology & Pain Medicine
RCT
Progressive Muscle Relaxation May Reduce Pain and Improve Sleep After Open Heart Surgery
Relaxation technique may help reduce pain and improve sleep after heart surgery
A single-center, single-blind RCT of 60 patients undergoing open heart surgery found that twice-daily Progressive Muscle Relaxation (PMR) on…
A simple relaxation technique helped heart surgery patients cut pain from a 9 out of 10 to just 1.5 and sleep better within three days.
Apr 3, 2026
Anesthesiology & Pain Medicine
RCT
VR application reduced pain and increased comfort after thyroid or parathyroid surgery in small RCT
Can a 15-minute nature video help ease pain after neck surgery?
A randomized controlled trial of 69 patients undergoing thyroid or parathyroid surgery found that a 15-minute VR application immediately red…
A 15-minute nature video in VR helped patients recovering from neck surgery feel less pain and more comfortable right after the session.
Apr 3, 2026
Anesthesiology & Pain Medicine
Meta-analysis
Meta-analysis finds opioid-free anesthesia improves postoperative recovery versus opioid anesthesia
Could avoiding opioids during surgery help patients recover better?
A systematic review and meta-analysis of 13 RCTs (n=1733) found opioid-free anesthesia improved quality of recovery (SMD 0.46), reduced resc…
Avoiding opioids during surgery helps patients recover faster with less pain medication and fewer nausea symptoms, though the real-world imp…
Apr 3, 2026
Anesthesiology & Pain Medicine
RCT
Opioid-sparing PCA non-inferior to opioid PCA for pain after total knee arthroplasty
Opioid-sparing pain control after knee replacement shows similar pain relief with less nausea
A randomized controlled trial of 98 patients undergoing total knee arthroplasty found an opioid-sparing PCA regimen (ketorolac and nefopam) …
A new pain method after knee replacement works just as well as standard care but cuts nausea from 35% down to 12%.
Apr 2, 2026
Anesthesiology & Pain Medicine
RCT
Combined Versus Deep Serratus Anterior Plane Block Shows No Difference in VATS Postoperative Pain
Study finds similar pain relief from two nerve block techniques after chest surgery
A single-center RCT in 60 patients undergoing elective VATS found no significant differences in 24-hour opioid consumption, rescue analgesia…
After chest surgery, patients got similar pain relief and used similar amounts of pain medicine whether they received one nerve block or a c…
Apr 2, 2026
Anesthesiology & Pain Medicine
RCT
Perineural dexamethasone extends analgesia duration in upper limb surgery blocks versus bupivacaine alone
Can a common steroid make pain relief from arm surgery last longer?
A double-blinded RCT in 90 ASA I/II patients undergoing upper limb procedures found adding 4 mg perineural dexamethasone to bupivacaine sign…
Adding a tiny amount of common steroid dexamethasone to arm surgery numbing shots nearly doubled pain relief time to over 20 hours with few …
Apr 2, 2026