Phase 3
N=230
Administration of Ketamine to Prevent the Post-operative Pain
Postoperative Pain · Breast Cancer
Bottom Line
View on ClinicalTrials.gov: NCT00210210 ↗Enrolled (actual)
230
Serious AEs
0.0%
Results posted
Sep 2025
Primary outcome: Primary: Morphine Consumption (First 48 Post-operative Hours) — 79; 77 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- Ketamine (Drug); Saline solution (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Institut Bergonié
- Primary completion
- Jul 2005
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Morphine Consumption (First 48 Post-operative Hours) |
79; 77 | — |
| SECONDARY Post-operative Pain |
106; 102; 3; 2 | — |
Summary
The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse effects. The purpose is to evaluate the analgesic effect of a receptor NMDA's antagonist ( ketamine)
Eligibility Criteria
Inclusion criteria
- Patients 18 years older
- ASA class 1 or 2
- with surgery of breast cancer (mastectomy or tumorectomy)
Exclusion criteria
.Kétamine hypersensitivity
- Major psychiatric disorders
- Major cardio-vascular disorders
- Major neurologic disorders
- Major ocular disorders
- Morphine in pre-operative period
Data sourced from ClinicalTrials.gov (NCT00210210). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.