Phase 3
Completed N=221
Biphasic Defibrillation Study: Trial to Compare Fixed Versus Escalating Energy
Source: ClinicalTrials.gov NCT00212992 ↗Enrolled (actual)
221
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcomePrimary: Successful Conversion to an Organized Heart Rhythm — 28; 39 Participants
◆ Published Evidence
Highly cited
119citations · ~6 / year
BIPHASIC Trial: a randomized comparison of fixed lower versus escalating higher energy levels for defibrillation in out-of-hospital cardiac arrest.
Summary
This study will compare the effect of constant low-level energy [150 joules] to an escalating energy [200-300-360 joules] regimen of biphasic waveform defibrillation on multiple patient outcomes.
Linked Publications
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BIPHASIC Trial: a randomized comparison of fixed lower versus escalating higher energy levels for defibrillation in out-of-hospital cardiac arrest.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Successful Conversion to an Organized Heart Rhythm |
28; 39 | — |
| SECONDARY Survival to Hospital Discharge |
19; 17 | — |
| SECONDARY Resuscitation for Survival to One Hour |
54; 44 | — |
| SECONDARY Neurologic Function |
2; 2 | — |
| SECONDARY Return of Spontaneous Circulation |
58; 52 | — |
| SECONDARY Survival to 24 Hours |
37; 38 | — |
Eligibility Criteria
Inclusion Criteria
- Witnessed cardiac arrest out-of-hospital requiring defibrillation and given by first responder using an automated external defibrillator
Exclusion Criteria
- Terminal illness or do-not-resuscitate (DNR) status
- No cardiopulmonary resuscitation (CPR) x 10 minutes
- Acute trauma
- Exsanguination
- Cardiac arrest experienced while in hospital
Data sourced from ClinicalTrials.gov (NCT00212992) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.