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Home › Conditions › Cardiac Arrest

Cardiac Arrest

Subtypes of Cardiac Arrest

Out-of-Hospital Cardiac Arrest 6 Sudden Cardiac Death 4 Sudden cardiac arrest 1

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cardiac Arrest

45 trials tracked for Cardiac Arrest: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 456 citations.

45Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 1 Phase 3 4 Phase 2 6 Phase 1 1 Other / NA 33
  1. Phase 3 Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia Completed · 456 cited
  2. Phase 3 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial Completed · 428 cited
  3. Phase 3 Biphasic Defibrillation Study: Trial to Compare Fixed Versus Escalating Energy Completed · 119 cited
  4. Phase 4 Antiplatelet Therapy After Cardiac Arrest Completed
  5. Phase 3 Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest Completed
  6. Phase 2 Bicarbonate in Patients With Out-of-hospital Cardiac Arrest Completed
Show 39 more trials
  1. Phase 2 Ubiquinol as a Metabolic Resuscitator in Post-Cardiac Arrest Completed
  2. Phase 2 Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest Completed
  3. Phase 2 Neuromuscular Blockade for Post-Cardiac Arrest Care Completed
  4. Phase 2 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed
  5. Phase 2 Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation Completed
  6. Phase 1 Reoxygenation After Cardiac Arrest II (REOX II Study) Completed
  7. N/A A Digital Flu Intervention for People With Cardiovascular Conditions Completed
  8. N/A Seizure Detection Using SEDline During Therapeutic Hypothermia in Cardiac Arrest Victims Completed
  9. N/A Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial Completed
  10. N/A Survey of Attitudes and Factors Associated With CPR in an Older Population Completed
  11. N/A Open Pilot Trial of a Mind-body Program for Cardiac Arrest Survivors and Their Caregivers Completed
  12. N/A Mastery Learning Versus Time-based Education: Skill Acquisition and Retention of Basic Life Support in Laypeople Completed
  13. N/A Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot Completed
  14. N/A Ultra-Brief Versus Brief Hands Only CPR Video Training With and Without Psychomotor Skill Practice Completed
  15. N/A Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest Completed
  16. N/A Pragmatic Airway Resuscitation Trial Completed
  17. N/A Removing Surrogates' Uncertainty to Reduce Fear and Anxiety After Cardiac Events Completed
  18. N/A Differences in Morbidity Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning Completed
  19. N/A Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest Completed
  20. N/A Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock Completed
  21. N/A MIHS Emergency Department CPR Quality Improvement Project Completed
  22. N/A Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios. Completed
  23. N/A Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR). Completed
  24. N/A Code Blue Outcomes & Process Improvement Through Leadership Optimization Using Teleintensivists-Simulation Completed
  25. N/A Bystander Fatigue and CPR Quality Using Continuous Compressions Versus 30:2 Compressions to Ventilation Completed
  26. N/A A Survey of Factors Associated With the Successful Recognition of Agonal Breathing and Cardiac Arrest. Completed
  27. N/A Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients Completed
  28. N/A The Care After Life-threatening Medical Events Study Completed
  29. N/A Acceptance and Mindfulness Based Exposure Therapy for Survivors of Cardiac Arrest Completed
  30. N/A Improving Cardiac Arrest Diagnostic Accuracy of Emergency Medical Dispatchers Completed
  31. N/A Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients Completed
  32. N/A Family-Authored ICU Diaries to Reduce Fear in Patients Experiencing a Cardiac Arrest (FAID Fear) Completed
  33. N/A Intraosseous Versus Intravenous Vascular Access During Cardiac Arrest Completed
  34. N/A Impact of Speed Of Rewarming After CaRdiac Arrest and ThErapeutic Hypothermia Completed
  35. N/A Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest Completed
  36. N/A Circulation Improving Resuscitation Care (CIRC) Completed
  37. N/A Pre-ROSC Intra-Nasal Cooling Effectiveness Completed
  38. N/A ECPR for Refractory Out-Of-Hospital Cardiac Arrest Completed
  39. N/A Effectiveness of Dispatch-Assisted Cardiopulmonary Resuscitation (CPR) Instructions Completed

Showing the 45 most-cited and recently-updated of 45 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Palliative care consultation increases do-not-resuscitate orders and decreases healthcare utilization in cardiac arrest and cardiogenic shock patients
Cardiology Sys. Review
Palliative care consultation increases do-not-resuscitate orders and decreases healthcare utilization in cardiac arrest and cardiogenic shock patients Palliative care linked to better choices for cardiac arrest patients
This narrative review examines palliative care for patients with cardiac arrest and cardiogenic shock and their caregivers. The authors repo…
A review suggests palliative care helps patients with cardiac arrest make decisions about life-sustaining treatments and lowers healthcare c…
Frontiers Jun 3, 2026
Initial intraosseous access shows no survival benefit over intravenous access in out-of-hospital cardiac arrest
Emergency Medicine RCT
Initial intraosseous access shows no survival benefit over intravenous access in out-of-hospital cardiac arrest New trial shows bone and vein access methods give similar survival rates for heart stop patients
This randomized clinical trial enrolled 1479 adults with non-traumatic out-of-hospital cardiac arrest to compare initial intraosseous vascul…
Doctors compared putting medicine in a bone versus a vein for adults whose hearts stopped outside a hospital. The study found no important d…
Jun 1, 2026
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest
Emergency Medicine Meta-analysis
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest New drug review shows no benefit for heart attack survivors
This systematic review and meta-analysis evaluated immunomodulatory therapeutics in adults following in- and out-of-hospital cardiac arrest.…
A large review of immune drugs found no clear benefit for heart attack survivors and did not lower death rates within 30 days.
Jun 1, 2026
Mini review examines sudden cardiac death risks in marathon runners across different age groups
Cardiology Sys. Review
Mini review examines sudden cardiac death risks in marathon runners across different age groups Marathon running links to higher heart risk in older men and full-distance participants
This mini review synthesizes evidence on sudden cardiac death (SCD) and coronary artery disease in marathon runners. The authors note that r…
A review of marathon runners shows heart risks vary by age, sex, and race distance, with most events happening near the finish.
Frontiers May 28, 2026
Intraosseous route for out-of-hospital cardiac arrest linked to lower outcomes than intravenous access
Emergency Medicine Meta-analysis
Intraosseous route for out-of-hospital cardiac arrest linked to lower outcomes than intravenous access Using a bone needle instead of a vein line lowers survival chances for cardiac arrest patients
This systematic review and meta-analysis of 245,132 out-of-hospital cardiac arrest patients found that intraosseous access was associated wi…
A huge study of over 245,000 people found that putting medicine into a bone vein works worse than using a standard arm vein. Doctors should …
NEJM May 12, 2026
Family history, prior arrhythmia, and anterior infarct location independently raise risk of ventricular fibrillation in STEMI patients
Cardiology Meta-analysis
Family history, prior arrhythmia, and anterior infarct location independently raise risk of ventricular fibrillation in STEMI patients Family history and heart attack location raise risk of dangerous heart rhythms in young patients
This meta-analysis of 1807 cases and 2923 controls confirms that family history of sudden death, previous atrial fibrillation, and anterior …
A large study found that family history of sudden death, past atrial fibrillation, and front heart attacks increase the chance of dangerous …
May 2, 2026
Hands-free carotid ultrasound improves ROSC detection in cardiac arrest
Emergency Medicine RCT
Hands-free carotid ultrasound improves ROSC detection in cardiac arrest Hands-free ultrasound speeds up heart restart checks for cardiac arrest patients
This randomized controlled trial of 341 adults with in-hospital cardiac arrest found that hands-free carotid ultrasound (CADFlow) led to a…
A new trial shows hands-free ultrasound devices help medical teams detect heart restart success faster and more accurately during cardiac ar…
May 1, 2026
Immediate coronary angiography showed no 5-year survival benefit versus delayed angiography in OHCA patients without ST elevation
Radiology & Imaging RCT
Immediate coronary angiography showed no 5-year survival benefit versus delayed angiography in OHCA patients without ST elevation Immediate heart scan after arrest shows no long-term survival gain
This randomized trial enrolled 552 patients resuscitated from out-of-hospital cardiac arrest without ST-segment elevation at nineteen Dutch …
Five years after a sudden cardiac arrest, patients who got an immediate heart scan did no better than those who waited, raising questions ab…
Apr 29, 2026
Immediate coronary angiography does not alter 30-day mortality in OHCA survivors without ST elevation
Emergency Medicine RCT
Immediate coronary angiography does not alter 30-day mortality in OHCA survivors without ST elevation Timing of heart scans does not change survival odds for older cardiac arrest survivors
This randomized controlled trial in 529 patients with out-of-hospital cardiac arrest compared immediate versus delayed coronary angiography.
New research shows rushing heart scans does not save more lives for older people after cardiac arrest without heart attack signs
Apr 29, 2026
Narrative review covers cardiovascular conditions and cognitive decline without reported trial data
Cardiology Sys. Review
Narrative review covers cardiovascular conditions and cognitive decline without reported trial data Your Heart and Brain Are Talking to Each Other
This narrative review addresses a broad scope of cardiovascular conditions, including stroke, heart failure, atrial fibrillation, and ischem…
Imagine your heart and brain as two best friends who never stop texting each other.
Frontiers Apr 22, 2026
Meta-analysis of coordinated AED systems for out-of-hospital cardiac arrest in Japan and Poland
Cardiology Meta-analysis
Meta-analysis of coordinated AED systems for out-of-hospital cardiac arrest in Japan and Poland Japan's AED System Could Save Lives in Poland
This meta-analysis synthesizes data from Seventeen studies regarding coordinated automated external defibrillator systems for patients with…
A unified national plan for AEDs works far better than scattered devices sitting alone.
Frontiers Apr 16, 2026
Plasma proteins linked to HCM severity identified in MYBPC3 carriers and UK Biobank
Cardiology
Plasma proteins linked to HCM severity identified in MYBPC3 carriers and UK Biobank Could blood proteins predict dangerous heart conditions like sudden cardiac arrest in people with specific gene mutations?
This observational study examined 144 MYBPC3 pathogenic variant carriers and 6,492 UK Biobank participants to identify plasma proteins assoc…
Blood proteins linked to heart failure and sudden cardiac arrest appear in people with specific gene mutations, offering new warning signs f…
medRxiv Apr 14, 2026

All Cardiac Arrest Articles