N/A
Completed N=4,561
Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario
Source: ClinicalTrials.gov NCT00235326 ↗Enrolled (actual)
4,561
Serious AEs
—
Results posted
Apr 2009
Primary outcomePrimary: Number of Participants With Post Infectious Irritable Bowel Syndrome — 23; 114 participants
Summary
Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood. This could allow material in the bowel to reach deeper tissues of the bowel wall leading to inflammation and changes in muscle and nerve function. This is also early evidence that genetic programming of people with PI-IBS prevents them from turning off inflammation once it begins. Literature suggests that IBS may develop at greater rates in individuals with pro-inflammatory genotype and that these individuals may be at increased risk of inflammatory bowel diseases (IBD).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Post Infectious Irritable Bowel Syndrome |
23; 114 | — |
Eligibility Criteria
Inclusion Criteria
- Participants must be residents of the Walkerton, Ontario region at the time of Outbreak who consented to the study
Exclusion Criteria
- Non residents of Walkerton Ontario at the time of outbreak
Data sourced from ClinicalTrials.gov (NCT00235326). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.