N/A
N=43
Magnetic Resonance Imaging Study of Geriatric Depression
Major Depressive Disorder
Bottom Line
View on ClinicalTrials.gov: NCT00245557 ↗Enrolled (actual)
43
Serious AEs
0.0%
Results posted
Feb 2010
Primary outcome: Primary: HAM-D 17 (Hamilton Depression Rating Scale) — 1.0; 18.5 Units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Sertraline (Drug)
- Age
- Adult, Older Adult · 55+ yrs
- Sex
- All
- Sponsor
- Mclean Hospital
- Primary completion
- Aug 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY HAM-D 17 (Hamilton Depression Rating Scale) |
1.0; 18.5 | — |
| PRIMARY Geriatric Depression Scale |
0.6; 9.1 | — |
| PRIMARY Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) |
.0432; .0397; .0410; .0496; .0512; .0515 | — |
Summary
The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.
Eligibility Criteria
Inclusion Criteria
- DSM- IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) diagnostic criteria for major depressive disorder
- Hamilton Depression Scale- 17 item version score of 18 or higher
- Must speak English
- Women must be post-menopausal
Exclusion Criteria
- A current or pervious psychiatric disorder other than MDD
- A current unstable medical condition
- A pacemaker or metal implant
- History of alcohol or drug dependence or abuse within the past year
- Current prescription of excluded medications
- Use of a drug within the last 30 days that was not approved for use by governmental authorities.
- If you or a family member works at McLean Hospital
Data sourced from ClinicalTrials.gov (NCT00245557). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.