Major Depressive Disorder

All Major Depressive Disorder Articles

• Heterogeneous definitions and clinical inconsistencies currently hinder the accurate identification of treatment-resistant depression
• Bidirectional link between cannabis use disorder and major depressive disorder affects over 3 million individuals
• Public health interventions improve mental health in young people in LMICs: systematic review
• Global analysis reveals high major depressive disorder rates among women during pregnancy and postpartum periods across diverse regions
• No significant association between BDNF genotypes and remission in major depressive disorder patients treated with antidepressants
• Emotion decoding deficits in older adults with depression may reflect impaired recognition, not hypersensitivity
• Cognitive Deficits in Major Depressive Disorder Linked to Psychosocial Function
• Review of Cannabis sativa for Major Depressive Disorder offers no clinical efficacy data
• Meta-analysis identifies genetic links between IBS and psychiatric traits in European ancestry populations
• Transdiagnostic behavior therapy shows comparable efficacy to disorder-specific therapies in veterans with depression, PTSD, and panic disorder
• IPD meta-analysis identifies risk factors for persistent PTSD and MDD after trauma
• CBT and STPP Reduce Avoidant Traits in Major Depressive Disorder
• FDA Approves Auvelity (dextromethorphan/bupropion) for Major Depressive Disorder and Agitation in Alzheimer's
• Adjunctive JNJ-42165279 fails to improve depression in SSRI/SNRI inadequate responders
• Text-message CBT treatment reduced generalized anxiety disorder symptoms in young adults compared to wait-list control
• Magnetic seizure therapy non-inferior to ECT for depression with better memory outcomes
• Systematic review finds aerobic exercise improves executive function in adults with major depressive disorder
• Infrared Thermography of Acupoints Shows Correlation with Depression Severity in Adolescents
• Parental severe mental illness associated with reduced offspring cognitive and academic performance in large meta-analysis
• MDD polygenic scores show adolescence-specific effects on child depressive symptoms in Norwegian cohort
• Observational Study Links Latitude and Genetics to Seasonal Affective Disorder Risk in Adults
• Narrative review proposes connectomic-guided psychosurgery framework for treatment-refractory patients
• Internet-delivered psychodynamic therapy versus cognitive behavioural therapy shows no difference for adolescent depression at 12-month
• Multimodal AI methods show 65–85% accuracy for Major Depressive Disorder compared to traditional diagnostic approaches
• Transcutaneous vagus nerve stimulation may improve reward-effort efficiency in major depressive disorder
• Narrative review of TRD epidemiology and CYP2C19 genotypes in Pakistan
• Baseline cognitive scores predict antidepressant non-response in Chinese adults with MDD
• Narrative review links ceramide elevations to major depressive disorder and suicidal vulnerability
• Multi-omics data integration in Spanish psychiatric patients and controls
• FDA Approves Spravato (esketamine) for Treatment-Resistant Depression and Depressive Symptoms with Acute Suicidal Ideation in Adults
• PETRUSHKA decision-support tool reduced treatment discontinuation and improved symptoms in major depressive disorder
• Mendelian randomization suggests loneliness causally increases schizophrenia and major depressive disorder risk
• Meta-analysis finds gamma neuromodulation benefits in schizophrenia and major depressive disorder
• Medically supervised ketogenic diet shows preliminary efficacy for moderate to severe major depressive disorder in a pilot trial
• Internet-based CBT relapse predictors in remitted major depressive disorder patients
• Chronic pain linked to 7.5-fold increase in severe depressive symptoms in UK Biobank analysis
• Sex-specific exposome components influence vulnerability to Major Depressive Disorder in women
• Group-based TSC intervention mediates improvements in depression and anxiety via insomnia severity in adults with MDD
• Seltorexant vs Quetiapine-XR for MDD: Similar Discontinuation, Numeric MADRS Benefit at Lower Dose
• Medication-free major depressive disorder associated with age-dependent accelerated structural brain aging compared to healthy controls
• Hypoxia-cognition training showed no significant effects on prefrontal or hippocampal microstructure in remitted mood disorder patients
• Algorithm-guided treatments may improve depression outcomes versus usual care in adults
• PCSK9 inhibitor initiation associated with lower depression risk versus statins in hyperlipidemia
• Multivariate GWAS identifies 248 loci for internalizing disorder and 591 for major depressive disorder in millions of participants
• Observational study examines antidepressant use patterns by sex and marital status in US adults
• Genetic study identifies 375 shared loci between major depression and multisite chronic pain
• Mindfulness meditation training modulates neural connectivity differently in healthy and depressed individuals
• FDA Approves Bupropion Hydrochloride Extended-Release Tablets (SR) (bupropion) for Major Depressive Disorder
• Meta-analysis identifies two genomic loci associated with antidepressant non-response in 135,471 individuals
• Meta-analysis finds mixed MRI patterns in subgenual cingulate cortex in medication-free MDD patients
• Meta-analysis finds error processing generally comparable in MDD versus healthy controls
• Meta-analysis identifies distinct and shared amygdala connectivity patterns in major depression and bipolar disorder
• Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD
• Inflammatory markers elevated in adolescent MDD with both self-injury and suicide attempts
• LSD Microdosing Shows Mood Improvement in Major Depressive Disorder: Phase 2a Trial
• Phase 2 Trial of Icalcaprant for MDD: Assessing Efficacy and Safety
• Serum Zinc and Iron Levels Reduced in MDD; Copper Levels Elevated