N/A Completed N=30 Health Services Research

A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.

orthostatic hypotension · Spinal Cord Injuries

Source: ClinicalTrials.gov NCT00248807 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2014

Primary outcomePrimary: Systolic Blood Pressure — 123; 125; 119; 122 mmHg

Summary

The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position. In this investigation we are studying blood pressure and blood flow to the brain, with and without a medication which lowers blood pressure (Vasotec). We will determine how persons with a spinal cord injury are able to maintain blood flow to the brain (not get dizzy) as they assume a more upright position and their blood pressure decreases.

Outcome Measures

Outcome	Result	p-value
PRIMARY Systolic Blood Pressure	123; 125; 119; 122	—
SECONDARY Cerebral Blood Flow	45.95; 42.52; 46.93; 37.38	—

Eligibility Criteria

Inclusion Criteria

Duration of spinal cord injury (SCI) at least 1 year
Level of SCI C4-8 and T6 and below
matched non-SCI subjects
Chronological age between 18-65 years
Euhydration: Subjects will be instructed to avoid caffeine and alcohol and to maintain normal salt and water intake for several days prior to study.

Exclusion Criteria

Known heart and/or blood vessel disease
Dehydration
High blood pressure
Kidney disease
Diabetes mellitus
Prescribed ACE inhibitors
Acute Infection
Smoking
Pregnancy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00248807). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.