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N/A N=30 Health Services Research

A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.

Orthostatic Hypotension · Spinal Cord Injuries

Bottom Line

View on ClinicalTrials.gov: NCT00248807 ↗
Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Jun 2014
Primary outcome: Primary: Systolic Blood Pressure — 123; 125; 119; 122 mmHg

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
1.25 mg enalaprilat IV (Drug); Head up tilt (HUT) (Other)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
VA Office of Research and Development
Primary completion
May 2009

Outcome Measures

OutcomeResultp-value
PRIMARY
Systolic Blood Pressure		 123; 125; 119; 122 —
SECONDARY
Cerebral Blood Flow		 45.95; 42.52; 46.93; 37.38 —

Summary

The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position. In this investigation we are studying blood pressure and blood flow to the brain, with and without a medication which lowers blood pressure (Vasotec). We will determine how persons with a spinal cord injury are able to maintain blood flow to the brain (not get dizzy) as they assume a more upright position and their blood pressure decreases.

Eligibility Criteria

Inclusion Criteria

  • Duration of spinal cord injury (SCI) at least 1 year
  • Level of SCI C4-8 and T6 and below
  • matched non-SCI subjects
  • Chronological age between 18-65 years
  • Euhydration: Subjects will be instructed to avoid caffeine and alcohol and to maintain normal salt and water intake for several days prior to study.

Exclusion Criteria

  • Known heart and/or blood vessel disease
  • Dehydration
  • High blood pressure
  • Kidney disease
  • Diabetes mellitus
  • Prescribed ACE inhibitors
  • Acute Infection
  • Smoking
  • Pregnancy
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00248807). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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