Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › orthostatic hypotension

Orthostatic hypotension

Part of Hypotension

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for orthostatic hypotension

18 trials tracked for orthostatic hypotension: 8 in phase 3 or 4 and 1 with published results. The most-cited published study has 7 citations.

18Trials tracked
8Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 5 Phase 3 3 Phase 2 4 Other / NA 6
  1. Phase 3 Treatment of Post-SCI Hypotension Completed · 7 cited
  2. Phase 4 Lundbeck TOMs Orthostatic Hypotension Completed
  3. Phase 4 Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury Completed
  4. Phase 4 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed
  5. Phase 4 A Study for Patients With Neurogenic Orthostatic Hypotension Completed
  6. Phase 4 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed
Show 12 more trials
  1. Phase 3 Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease Completed
  2. Phase 3 A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease Completed
  3. Phase 2 The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Completed
  4. Phase 2 TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) Completed
  5. Phase 2 Safety and Efficacy of L-NAME and Midodrine to Increase MAP Completed
  6. Phase 2 A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride Completed
  7. N/A Advancing Understanding of Transportation Options Completed
  8. N/A Orthostatic Hypotension in Rehabilitation Patients Completed
  9. N/A A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury. Completed
  10. N/A Orthostatic Hypotension Treatment on Rehab Unit Completed
  11. N/A RAAS and Arterial Stiffness in SCI Completed
  12. N/A Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery Completed

Showing the 18 most-cited and recently-updated of 18 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Orthostatic hypotension: what the trials found

Midodrine hydrochloride has been evaluated in multiple trials for the management of orthostatic hypotension. Evidence indicates significant improvements in clinical markers, including a reduction in OHSA Item 1 scores (p<0.001) 4 and increased time to syncope or near-syncope during tilt table testing (p=0.0131) 5.

Droxidopa has demonstrated efficacy in specific domains; while changes in overall OHQ scores were not statistically significant 8, there was a significant reduction in symptoms related to dizziness, lightheadedness, and feeling faint/blacking out (OHSA Item 1) 8.

Clinical assessments of autonomic function and blood pressure dynamics have been conducted in patients with underlying conditions, showing measurable changes in systolic blood pressure during tilt maneuvers 7.

Recent results — preliminary, needs further review

  • Pyridostigmine Bromide showed significant improvements in Peak Oxygen Uptake (p=0.043) and Peak-Rest Oxygen Uptake (p=0.008), though results for Peak Cardiac Output were not statistically significant 9.

For the clinician treating this condition

  • Midodrine hydrochloride is supported by evidence showing significant reductions in orthostatic hypotension symptoms and increased time to syncope during tilt table testing.
  • Droxidopa specifically improves symptoms of dizziness and lightheadedness (OHSA Item 1), despite non-significant changes in overall OHQ scores.
  • Pharmacological interventions like Midodrine and Droxidopa are established options for managing orthostatic hypotension, with varying degrees of impact on specific symptom scales.

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Pilot Abstract Reports Artificial Baroreflex System With DBS in Parkinson Disease Patients
Cardiology
Pilot Abstract Reports Artificial Baroreflex System With DBS in Parkinson Disease Patients Brain Zaps May Soon Stabilize Blood Pressure
This pilot study abstract involving 3 patients with Parkinson disease reports low certainty due to the small sample size.
A new brain stimulation system could stop dangerous blood pressure crashes that cause Parkinson's patients to faint when standing up.
medRxiv Apr 19, 2026

Research across Hypotension

Related studies from across the Hypotension family.

Normal saline preservation solution increases serum sodium and blood pressure versus half saline in critically ill pediatric patients
Pediatrics RCT
Normal saline preservation solution increases serum sodium and blood pressure versus half saline in critically ill pediatric patients Study in critically ill children compares two IV fluid types for sodium and blood pressure effects
A double-blind RCT of 88 critically ill pediatric patients in a PICU compared normal saline (0.9% sodium chloride) to half saline (0.45% sod…
Normal saline raises sodium and blood pressure more than half saline in critically ill children, guiding safer fluid choices for recovery.
NEJM Apr 6, 2026
Higher baseline chondroitin sulfate predicts greater mortality benefit from restrictive fluid strategy in sepsis
Emergency Medicine RCT
Higher baseline chondroitin sulfate predicts greater mortality benefit from restrictive fluid strategy in sepsis Blood marker may help predict which sepsis patients benefit from less fluid
A biomarker analysis within an RCT of 574 patients with sepsis-associated hypotension found that higher baseline plasma chondroitin sulfate …
A blood marker may help doctors decide which sepsis patients benefit most from receiving less intravenous fluid during treatment.
Apr 2, 2026