Phase 3
Completed N=71
Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease
Source: ClinicalTrials.gov NCT00287690 ↗Enrolled (actual)
71
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcomePrimary: Coronary Artery Diameter — 3.1; 2.7 mm
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The aim of this study is to investigate the effect of genistein administration on coronary arteries in humans. We will measure the size of a coronary artery and the speed and amount of blood flow in response after subjects have ingested Supro® drinks (a soy protein drink containing genistein).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Coronary Artery Diameter |
3.1; 2.7 | — |
| PRIMARY Coronary Blood Flow |
77; 68 | — |
| SECONDARY Serum Genistein Concentrations |
340; 3.9 | — |
Eligibility Criteria
Inclusion Criteria
- Aged 30-75 years
- Patients requiring diagnostic coronary angiography
- Presence of coronary artery disease on angiogram but with at least one non-obstructed (lesions 40 IU/L)
- Willing to give informed, written consent
Exclusion Criteria
- Age 75 years
- Allergy to radiographic contrast media
- Sino-atrial disease or significant bradycardia
- Concomitant medication with persantin (dipyridamole) or theophyllines
- Asthma
- Hypertension
- Left ventricular hypertrophy or dysfunction (clinical/ECG/echo/CXR)
- Female patients with FSH<40 IU/L (postmenopausal)
- Female patients currently taking hormone therapy, or who have taken hormone therapy in previous 6 months
- Unwilling to give written informed consent
- Participation in another study within previous 60 days
Data sourced from ClinicalTrials.gov (NCT00287690). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.