IVUS-guided PCI did not significantly reduce target-vessel failure compared to angiography-guided PCI
Trial shows IVUS guidance does not reduce risk for heart patients
This randomized controlled trial of 2020 patients undergoing complex PCI found that IVUS-guided PCI with stent-optimization criteria resulte…
New data suggests that using special ultrasound imaging during complex heart procedures may not lower the risk of major complications.
Pre-transplant coronary artery disease increases all-cause mortality and post-transplant cardiovascular events in kidney recipients
Pre-existing heart disease increases risks for kidney transplant patients
This meta-analysis of 112,416 kidney transplant recipients found that pre-existing coronary artery disease (CAD) is associated with signific…
Patients with pre-existing coronary artery disease face significantly higher risks of death and graft failure after receiving a kidney trans…
High-intensity interval aerobic exercise improves brachial FMD in coronary artery disease and heart failure
High intensity interval training improves blood flow in heart patients
This network meta-analysis of 6,818 adults with coronary artery disease or chronic heart failure found that high-intensity interval aerobic …
Specific types of intense exercise may improve blood vessel function for people living with heart failure or coronary artery disease.
Higher pan-immune-inflammation value linked to worse outcomes after PCI for ACS
High inflammation scores predict worse heart outcomes in patients with acute coronary syndrome
This systematic review and meta-analysis of 18,715 adults with acute coronary syndrome undergoing PCI found that higher pan-immune-inflammat…
A new analysis shows higher inflammation markers predict death and heart failure in adults with acute coronary syndrome undergoing heart pro…
Colchicine reduces major adverse cardiovascular events in coronary artery disease without increasing serious adverse events
Low-dose colchicine reduces heart attack risk for coronary artery disease patients
This systematic review and meta-analysis evaluated colchicine in patients with coronary artery disease and acute coronary syndromes. The ana…
A large analysis shows low-dose colchicine lowers major heart events for coronary artery disease patients without increasing serious risks, …
Sirolimus and paclitaxel-coated balloons show similar outcomes for coronary in-stent restenosis
Sirolimus and paclitaxel balloons show similar results for heart disease
This GRADE-assessed systematic review and meta-analysis of 3,633 participants with coronary artery disease found no notable variations betwe…
Two drug-coated balloons for coronary artery disease work about equally well, a new analysis finds.
Polymer-free and biodegradable-polymer drug-eluting stents show comparable outcomes in PCI
New review shows polymer-free stents work like biodegradable ones for heart patients
A meta-analysis compared polymer-free drug-eluting stents (PF-DES) with biodegradable-polymer drug-eluting stents (BP-DES) in patients under…
A large study of over 11,000 patients found that polymer-free stents are just as safe as older biodegradable ones. Doctors saw no major diff…
Placlitaxel drug-coated balloons reduce MACE and revascularization versus limus-eluting stents in bifurcation lesions
Drug-coated balloons cut heart risks for side branch lesions better than stents
This meta-analysis reviews data from patients with side branch lesions in true coronary bifurcations undergoing percutaneous coronary interv…
A review of 898 patients shows drug-coated balloons significantly reduce heart risks compared to stents for specific coronary artery blockag…
Breast arterial calcification on mammography predicts higher cardiovascular event risk in women
Calcium on mammograms signals higher heart risk for women
This systematic review and meta-analysis evaluated breast arterial calcification (BAC) in women across approximately 25,000 participants in …
Calcium seen on mammograms links to higher heart attack risk in women. This large review found a strong connection between breast arterial c…
Mini review examines sudden cardiac death risks in marathon runners across different age groups
Marathon running links to higher heart risk in older men and full-distance participants
This mini review synthesizes evidence on sudden cardiac death (SCD) and coronary artery disease in marathon runners. The authors note that r…
A review of marathon runners shows heart risks vary by age, sex, and race distance, with most events happening near the finish.
Serum resistin levels rise progressively with worsening severity of coronary heart disease and acute myocardial infarction in this meta-analysis
High blood resistin levels linked to heart disease severity in large analysis
A network meta-analysis of 9,169 subjects reveals that serum resistin levels increase stepwise as coronary heart disease severity worsens. W…
A large network meta-analysis found that higher serum resistin levels are linked to worse coronary heart disease and acute heart attacks.
Pre-infection vaccination linked to lower cardiovascular and cerebrovascular event risks in SARS-CoV-2 infected individuals
Vaccination Before Infection Cuts Heart and Stroke Risks in COVID Patients
This systematic review and meta-analysis examined the association between pre-infection COVID-19 vaccination and cardiovascular outcomes in …
Pre-infection COVID-19 vaccination significantly lowers risks of heart attacks, strokes, and other cardiovascular events in infected individ…
Research across Myocardial ischemia
Related studies from across the Myocardial ischemia family.
IVUS-guided PCI shows no significant difference over angiography-guided PCI for primary outcomes
Trial shows ultrasound imaging adds no benefit for heart surgery
This randomized controlled trial of 806 patients with unprotected left main coronary artery disease found that IVUS-guided PCI did not signi…
A large trial found that using ultrasound guidance during certain heart procedures did not improve safety or outcomes compared to standard m…
Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients
Timing of heart surgery does not change survival for a specific heart attack group
This meta-analysis reviewed 5077 patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease comparing …
A large review found that waiting for staged heart surgery did not improve survival or reduce heart attacks compared to immediate surgery fo…
OCT guidance showed non-significant MACE reduction in true unprotected left main bifurcation disease compared to angiography
Doctors used special imaging tools to help place stents in heart arteries safely
This randomized controlled trial enrolled 227 patients with true unprotected left main bifurcation lesions. Optical coherence tomography (OC…
A study tested using optical coherence tomography to guide stent placement in complex heart artery cases. While the imaging was mostly succe…
Five-year economic and quality of life outcomes favor PCI with zotarolimus stents over CABG in 3-vessel CAD
Five-year follow-up reveals lower costs and better employment for PCI over surgery in complex heart disease
This randomized trial compared fractional flow reserve-guided PCI using zotarolimus drug-eluting stents with coronary artery bypass grafting…
Patients with complex heart disease treated with stents had lower costs and better quality of life than those who had surgery after five yea…
Retrospective cohort finds inverse triglyceride relationship with mortality in left main coronary artery disease
Low Fat, High Risk: Why Less Triglyceride Means Longer Life
This retrospective cohort study evaluated 2,778 patients with left main coronary artery disease undergoing percutaneous coronary interventio…
Imagine your heart is a busy highway. For years, doctors thought high cholesterol was the only traffic jam causing crashes.
Narrative review outlines practical framework for combined lipid and anti-inflammatory therapy in coronary atherosclerosis
Your Heart Has a Hidden Fire
This narrative review examines the role of colchicine and IL-1β inhibitors in patients with coronary atherosclerosis.
Doctors now know you must fight two enemies at once: the bad fats in your blood and the hidden inflammation that makes them dangerous.
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
FFR-guided complete revascularization reduces unplanned revascularization in MI patients with multivessel CAD
Complete Heart Repair May Stop Future Emergencies
A meta-analysis of 3,054 patients with myocardial infarction and multivessel coronary artery disease found that FFR-guided complete revascul…
Fixing all blocked heart arteries during surgery may stop future emergencies and unplanned procedures for patients with heart attacks.
Ticagrelor Not Noninferior to Prasugrel in Diabetes Patients With Multivessel CAD After PCI
New study shows ticagrelor did not beat prasugrel for heart attack prevention in diabetics
This randomized clinical trial of 1,800 patients with diabetes and multivessel coronary artery disease undergoing PCI compared ticagrelor pl…
For diabetics with heart stents, a new study found ticagrelor offered no clear advantage over prasugrel in preventing death, heart attacks, …
iFR-guided CABG improves mid-term graft patency versus angiography alone in multivessel disease
Can a simple test during heart surgery help grafts stay open longer?
A single-blinded RCT in patients with multivessel disease and intermediate stenoses found iFR-guided CABG significantly improved LIMA-to-LAD…
A simple pressure test during heart surgery keeps new blood vessel grafts open longer, with 80.5% staying clear versus 56.8% with standard i…
Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
Can a cheap anti-inflammatory drug slow heart disease? It might help reduce plaque buildup
In the EKSTROM RCT (n=84), low-dose colchicine (0.5 mg/day) did not significantly reduce low attenuation plaque volume (median change 0.1 vs…
A cheap anti-inflammatory drug called colchicine may help slow total plaque buildup in arteries for people already managing stable heart dis…
Questions about Coronary Artery Disease
Is having lower blood pressure at the start of treatment linked to higher risk in stable CAD?
Yes, a post-hoc analysis of the AFIRE trial found that in patients with atrial fibrillation and stable CAD, lower baseline systolic blood pressure (≤126 mmHg) was linked to higher cardiovascular risk compared to higher SBP.
Full answer →Can an AI model help doctors decide on my treatment plan for Percutaneous Coronary Intervention?
AI models are not yet proven to help doctors decide on PCI treatment plans; current research focuses on imaging and risk scores, not AI decision support.
Full answer →Does having metabolic syndrome increase my risk of restenosis after Percutaneous Coronary Intervention?
Current evidence does not show a clear link between metabolic syndrome and higher restenosis risk after PCI, though related factors like insulin resistance may play a role.
Full answer →Is proton pump inhibitor use increasing for Chinese patients with acute coronary syndrome?
Yes, PPI use is increasing among Chinese ACS patients, rising from 21.3% (2010-2012) to 63.5% (2016-2018) in one study, with over 60% prescribed PPIs in a 2017-2018 registry.
Full answer →What drug-drug interactions should I watch for while hospitalized with acute coronary syndrome?
While hospitalized for acute coronary syndrome, watch for interactions between blood thinners (aspirin, ticagrelor, heparin) and other drugs like ramipril, PPIs, and smoking cessation aids; your care team monitors these closely.
Full answer →Do SGLT-2 inhibitors help reduce heart failure hospitalization for acute coronary syndrome?
Yes, SGLT-2 inhibitors reduce the risk of first heart failure hospitalization in patients with acute coronary syndrome, according to a 2024 meta-analysis.
Full answer →Does using imaging guidance during stenting lower heart attack risk for older patients with coronary artery disease?
Yes, imaging guidance (IVUS or OCT) during stenting lowers heart attack and MACE risk in older patients, according to a 2024 meta-analysis of 9 RCTs.
Full answer →Can a CT scan accurately measure my coronary artery disease blockages compared to invasive tests?
CT scans (CCTA) can detect blockages but tend to underestimate their severity compared to invasive angiography, so they are not a perfect replacement.
Full answer →All Coronary Artery Disease Articles
- IVUS-guided PCI did not significantly reduce target-vessel failure compared to angiography-guided PCI
- Pre-transplant coronary artery disease increases all-cause mortality and post-transplant cardiovascular events in kidney recipients
- High-intensity interval aerobic exercise improves brachial FMD in coronary artery disease and heart failure
- Higher pan-immune-inflammation value linked to worse outcomes after PCI for ACS
- Colchicine reduces major adverse cardiovascular events in coronary artery disease without increasing serious adverse events
- Polymer-free and biodegradable-polymer drug-eluting stents show comparable outcomes in PCI
- Sirolimus and paclitaxel-coated balloons show similar outcomes for coronary in-stent restenosis
- Breast arterial calcification on mammography predicts higher cardiovascular event risk in women
- Placlitaxel drug-coated balloons reduce MACE and revascularization versus limus-eluting stents in bifurcation lesions
- Serum resistin levels rise progressively with worsening severity of coronary heart disease and acute myocardial infarction in this meta-analysis
- Mini review examines sudden cardiac death risks in marathon runners across different age groups
- Pre-infection vaccination linked to lower cardiovascular and cerebrovascular event risks in SARS-CoV-2 infected individuals
- Preclinical review suggests Danggui Sini Granule improves markers in a rat vasospastic CHD model
- Meta-analysis shows PCI before TAVR reduces revascularization but increases bleeding risk in severe aortic stenosis patients with coronary artery disease
- Guideline on cost-effectiveness of add-on ezetimibe for statin-intolerant acute coronary syndrome patients in Thailand
- Meta-analysis finds higher target-lesion revascularization with Magmaris scaffold vs. DES in ACS
- Inclisiran plus usual care improves LDL-C goal attainment after acute coronary syndrome
- Residual angina occurs in 42.2% of patients after anatomic complete revascularization for chronic coronary disease
- Meta-analysis finds systemic lupus erythematosus elevates coronary artery disease risk
- Systematic review and meta-analysis of drug-coated balloons versus drug-eluting stents in coronary artery disease
- Narrative review explores strategic collaborations to expand interventional cardiology access in sub-Saharan Africa
- OCT guidance showed non-significant MACE reduction in true unprotected left main bifurcation disease compared to angiography
- Systematic review and meta-analysis compares jailed balloon versus jailed wire techniques for bifurcation PCI
- Active cancer associated with higher mortality in acute coronary syndromes, PCI may mitigate risk
- FDA approves ticagrelor for multiple indications in cardiology and neurology
- Protocol for a randomized trial of Shenqi Yangxin Formula in stable coronary artery disease
- SGLT-2 inhibitors reduce heart failure hospitalization and stroke in patients with acute coronary syndrome
- Systematic review and meta-analysis reports 36.6% cognitive impairment prevalence in coronary heart disease patients
- Elective unloading with a microaxial flow pump showed no material difference in outcomes versus standard care in severe left ventricular dysfunction
- Meta-analysis links metabolic and inflammatory markers to coronary slow flow phenomenon risk
- Meta-analysis finds no significant difference in target-lesion failure between bioadaptor and DES at 1 year
- CABG versus PCI in high-risk coronary revascularisation patients shows mixed outcomes over 5 years
- Tailored antiplatelet strategy showed no benefit over standard dual therapy in high-risk PCI patients
- Systematic review finds CCTA underestimates SYNTAX scores versus invasive angiography in coronary artery disease
- Cardiac rehabilitation reduces major adverse cardiac events and mortality in coronary artery disease patients after PCI
- Meta-analysis finds no mortality difference for PCI with surgical backup
- Meta-analysis finds intravascular imaging reduces MACE in older PCI patients
- MUSKARDIA shows protective trend in stable CAD with reduced eGFR
- Reflexology hand massage reduces pain and anxiety after coronary angiography
- Structured Exercise Training Improves LVEF and LDL-C in HFmrEF Patients After PCI
- Meta-Analysis Identifies Risk Factors for Adverse Outcomes in MINOCA Patients
- Routine lab indicators help differentiate typical from incomplete Kawasaki disease and predict coronary lesions
- Paclitaxel-coated balloons and sirolimus-eluting stents in noncomplex coronary bifurcation lesions
- Systematic side branch intervention compared to conservative strategy in coronary bifurcation lesions
- Systematic review and meta-analysis shows transitional care reduces readmission and MACE in PCI patients
- Five-year economic and quality of life outcomes favor PCI with zotarolimus stents over CABG in 3-vessel CAD
- Sirolimus-eluting iron bioresorbable scaffold shows higher late lumen loss than everolimus-eluting stents in coronary artery disease patients
- Intravascular imaging-guided PCI reduces adverse events compared to angiography-guided PCI in patients with complex coronary artery lesions
- Narrative review examines coronary risk and vascular effects of bisphosphonates, denosumab, and romosozumab in osteoporosis
- Off-pump CABG showed similar wound complications but fewer transfusions and shorter stays versus on-pump CABG in 394 patients
- Poor R-wave progression and all-cause mortality in adults without coronary artery disease
- Epicardial adipose tissue volume normalized to heart volume associated with obstructive coronary artery disease
- Review of Swedish SCAD patients notes modest actionable variant yield in exome sequencing data
- Two-week time-restricted eating reduced neutrophil counts and systemic inflammation in patients with established coronary artery disease
- Post-PCI Angiographic Microcirculatory Resistance and 3-Year Cardiac Events in FAVOR III China
- Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality
- Cross-sectional review links antecedent autonomic symptoms to burden in SCAD survivors
- Point-of-care high-sensitivity troponin I shortens ED stays for possible acute coronary syndrome
- Lipoprotein(a) concentrations associate with coronary artery disease severity in single-center observational cohort of 238 adults
- Admission HbA1c and In-Stent Restenosis in CAD Patients After PCI
- Inflammatory indices associated with increased chronic kidney disease risk in coronary artery disease cohort
- Polygenic risk score enrichment reduces sample size needs for coronary artery disease and inflammatory bowel disease trials
- Review of fine-tuned AI model for coronary artery disease image analysis and report generation
- Review of Visual Standardized Quantification for LGE in Cardiomyopathy
- Prospective review of biomarkers and revascularization in 2251 patients with chronic coronary syndrome over 12.6 years
- AI coronary CT features correlate with flow reserve in coronary artery disease patients
- Remote i-CARE intervention improves self-care behaviors in coronary artery disease patients
- Review of ginsenoside CK shows potential antiplatelet, anti-inflammatory, and cardioprotective effects in cardiovascular disease models
- Bidirectional Mendelian randomization suggests inverse association between hypertension liability and gastric cancer risk
- Intrinsic capacity score predicts rehospitalization risk after PCI in CAD patients
- Prospective observational study identifies 2,504 potential drug-drug interactions among hospitalized patients with acute coronary syndrome
- Observational biobank study compares phenomic and social determinants for disease risk prediction
- Polygenic risk scores for coronary artery disease capture 10.8% to 33.1% of benchmark patients in early-onset CAD cohort
- Obesity-metabolic indices associated with heart failure in coronary artery disease patients
- Observational study links AI-detected proximal coronary calcium to higher MACE and mortality risk
- CABG linked to higher impaired cognition risk in older CAD patients with APO genotype variation
- CMR-guided management improves treatment satisfaction in patients with ANOCA
- Narrative review explores aged epicardial adipose tissue as a target for mitigating age-related coronary artery calcification in the elderly
- Gastrointestinal complications in cardiac surgery patients are linked to high mortality and multiorgan failure
- Endothelial cell isolation feasible in 43% of ANOCA patients in observational study
- Cross-Sectional Study Shows Rising PPI Use in Chinese ACS and AF Patients at Discharge
- PCI Reduces MACE in Nonfrail Patients With CAD and Severe Aortic Stenosis Undergoing TAVR
- Residual global μQFR assessment associated with 3-year MACE risk in acute coronary syndrome patients
- Narrative review discusses calcium-modifying balloons for PCI in calcified coronary disease
- Mini-review examines coronary artery calcium scoring for risk stratification and plaque progression
- FFR-guided complete revascularization reduces unplanned revascularization in MI patients with multivessel CAD
- TyG indices associated with coronary artery disease risk in first-time angiography patients
- TyG index predicts complex CAD in young adults with aortic valve calcification
- Shorter heparin-to-bivalirudin bridging times (≤30 min) reduce hospitalization in acute coronary syndrome patients undergoing PCI
- Ten-year HOST-EXAM trial data show clopidogrel reduces major adverse events versus aspirin in chronic PCI maintenance
- Deferral of PCI non-inferior to routine PCI before TAVI in coronary artery disease patients
- Meta-analysis of DOACs versus conventional anticoagulation in Kawasaki disease with giant coronary artery aneurysms
- Retrospective study links coronary artery disease to EEG connectivity changes in elderly patients with hypertension
- Complex PCI is associated with higher risks of myocardial infarction, bleeding, and death compared to non-complex PCI in revascularization patients
- Smartphone-based nursing intervention reduces pain after coronary artery bypass grafting
- AI applications in acute care showed potential but face significant implementation challenges
- Metabolic syndrome and TyG index associated with higher in-stent restenosis risk after PCI
- CI-AKI in ACS patients undergoing PCI was associated with a 4.7-fold increased hazard of death within 90 days
- Marburg Heart Score and INTERCHEST show modest discrimination comparable to standard protocol for acute chest pain triage
- Ticagrelor Not Noninferior to Prasugrel in Diabetes Patients With Multivessel CAD After PCI
- Edoxaban monotherapy reduces adverse events compared to dual therapy in patients with atrial fibrillation and coronary artery disease
- OCT-guided PCI shows better early stent coverage than angiography in NSTE-ACS imaging study
- Intravascular imaging and FFR-guided PCI reduce major adverse cardiovascular events versus angiography
- In-hospital double-dose influenza vaccine reduces MACE and death in ACS patients with prior stroke compared to delayed standard-dose
- Fine-mapping analysis identifies thousands of genetic variants contributing to coronary artery disease risk in over one million individuals
- LEGEND rule-out strategy reduces length of stay and testing in suspected ACS patients across four Australian emergency departments
- Network meta-analysis of 14 RCTs shows upfront plaque modification increases minimum stent area but does not reduce MACE or TLR in calcified coronary lesions
- Intensive medical treatment failed to reduce major adverse cardiovascular events in women with suspected ANOCA/INOCA over 2.5 years
- Post-hoc analysis links lower systolic BP to higher cardiovascular risk in AF and stable CAD
- Meta-analysis finds exercise training reduces hospitalization risk in coronary artery disease patients
- PCI with newer drug-eluting stents shows similar 10-year mortality to CABG for left main disease
- Systemic inflammation indices MLR, SIRI, and AISI associated with carotid plaques in ACS patients
- Previously catheterised radial arteries show lower bypass graft patency in CABG patients
- Machine learning models predict mortality in ICU patients with coronary artery disease
- iFR-guided CABG improves mid-term graft patency versus angiography alone in multivessel disease
- HIIT improves exercise capacity in cardiovascular rehabilitation for CAD, HF, and atrial fibrillation
- Genetic factor in BCAA metabolism linked to type 2 diabetes and coronary artery disease risk
- Mini-review examines myocardial perfusion imaging advances across PET, SPECT, CMR, and CT modalities
- LLM ensemble shows potential for PCI decision support in retrospective analysis of 93 patients
- Robotic PCI system shows feasibility in small study of complex coronary lesions
- Higher vs lower heparin dosing for elective PCI tested in cluster randomized trial design
- Optimism training improves psychological outcomes but shows uncertain biomarker effects in stable CAD patients
- Topical milrinone or nitroglycerin studied for internal mammary artery flow in CABG patients
- Meta-analysis finds no outcome differences between free versus in situ right internal mammary artery in CABG
- Meta-analysis finds 2% mean prevalence of class 1 revascularization indications in prekidney transplant CAD screening
- Phase 3 trial of milvexian for ACS prevention completes enrollment
- Accelerated stress CMR non-inferior to standard protocol, saves 24 minutes per scan
- Increased LV mass linked to discordant stress CMR/ICA results via microvascular resistance
- Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
- Angiography-derived FFR reduces perioperative events in CABG for valve surgery patients
- Microvascular Resistance Reserve Predicts CAD Outcomes: HR 0.75 per Unit Increase
- Early Aspirin Withdrawal Post-PCI Reduces Bleeding, No MI Increase with P2Y12 Monotherapy