Phase 2
N=746
Gradual vs. Abrupt Cessation Treatment for Smoking
Smoking Cessation
Bottom Line
View on ClinicalTrials.gov: NCT00297492 ↗Enrolled (actual)
746
Serious AEs
0.0%
Results posted
Sep 2012
Primary outcome: Primary: Number of Participants With Prolonged Abstinence Through 6 Months Verified by Carbon Monoxide Measurement — 12; 20; 7 participants — p=0.30
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Reduction Phone Counseling (Behavioral); Abrupt Phone Counseling (Behavioral); Minimal Abrupt Phone Counseling (Behavioral); Pre-Quit Nicotine Lozenges (Drug); Post-Quit Nicotine Lozenges (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Vermont
- Primary completion
- Feb 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Prolonged Abstinence Through 6 Months Verified by Carbon Monoxide Measurement |
12; 20; 7 | 0.30 |
Summary
This study tests whether stopping smoking by gradually cutting down first is more or less successful than stopping abruptly. We hypothesize that stopping by gradually cutting down first will produce more abstinence than stopping abruptly.
Eligibility Criteria
Inclusion Criteria
- Interested in quitting gradually
- At least 18 years old
- Daily cigarette smoker
- Smoke at least 15 cigarettes per day (CPD)
- No change greater than 20% in CPD in the last month
- Interested in quitting in next 30 days
- Must agree to not use non-cigarette tobacco during study
- No use of smoking cessation medication in last month
- Have phone with voice mail
- Willing to use nicotine lozenge
- No other person in household in study
- Fluent/literate in English
Exclusion Criteria
- Women who are pregnant or breastfeeding
- Currently using medication for depression or asthma
- Heart disease requiring medication
- Heart attack in last month
- Irregular heartbeat
- High blood pressure not controlled by medication
- Stomach ulcers
- Diabetes
Data sourced from ClinicalTrials.gov (NCT00297492). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.