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Home › Conditions › Smoking Cessation

Smoking Cessation

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Smoking Cessation

266 trials tracked for Smoking Cessation: 81 in phase 3 or 4 and 33 with published results. The most-cited published study has 183 citations.

266Trials tracked
81Phase 3 & 4
0Recruiting
33With published results
Phase distribution
Phase 4 53 Phase 3 28 Phase 2 36 Phase 1 14 Other / NA 135
  1. Phase 4 A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers Completed · 183 cited
  2. Phase 4 Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders. Completed · 149 cited
  3. Phase 3 Pharmacogenetics, Emotional Reactivity and Smoking Completed · 134 cited
  4. Phase 4 Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking Cessation Completed · 112 cited
  5. Phase 3 Combining Varenicline and Bupropion for Smoking Cessation Completed · 112 cited
  6. Phase 3 Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence Completed · 95 cited
Show 44 more trials
  1. Phase 4 Treatment of Smoking Lapses and Relapses Completed · 92 cited
  2. Phase 3 A Study of Cytisinicline for Smoking Cessation in Adult Smokers Completed · 80 cited
  3. Phase 3 Disease Management for Smoking Cessation Completed · 77 cited
  4. Phase 4 Relapse Prevention With Varenicline Completed · 72 cited
  5. Phase 4 Smoking Cessation Treatment for Methadone Maintenance Patients Completed · 72 cited
  6. Phase 4 Advancing Tobacco Use Treatment for African American Smokers Completed · 72 cited
  7. Phase 4 Understanding Disparities in Quitting in African American and White Smokers Completed · 63 cited
  8. Phase 4 A Comparative Effectiveness RCT of Optimized Cessation Treatments Completed · 41 cited
  9. Phase 4 Genetically Informed Smoking Cessation Trial Completed · 36 cited
  10. Phase 4 Smoking Cessation Study In Healthy Adolescent Smokers Completed · 34 cited
  11. Phase 4 Smoking Cessation in Hospitalized Smokers Completed · 30 cited
  12. Phase 3 Smoking Cessation for American Indians Completed · 29 cited
  13. Phase 4 Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders Completed · 25 cited
  14. Phase 4 Post-Discharge Smoking Cessation Strategies: Helping HAND 4 Completed · 24 cited
  15. Phase 4 Extended Treatment for Smoking Cessation Completed · 23 cited
  16. Phase 4 Nicotine Replacement for Smoking Cessation During Pregnancy Completed · 21 cited
  17. Phase 3 A Randomized Trial of Medi-Cal Beneficiaries Calling the California Smokers' Helpline Completed · 21 cited
  18. Phase 4 Smoking Cessation in Hispanic Construction Workers Completed · 20 cited
  19. Phase 3 A Second Study of Cytisinicline for Smoking Cessation in Adult Smokers Completed · 17 cited
  20. Phase 4 Integrating Financial Management Counseling and Smoking Cessation Counseling to Reduce Health and Economic Disparities in Low-Income Immigrants Completed · 15 cited
  21. Phase 4 Addressing Racial/Ethnic Tobacco Health Disparities Via Group Intervention Completed · 14 cited
  22. Phase 4 A Text Messaging Program for Smokers in Primary Care Completed · 12 cited
  23. Phase 3 Individualizing Pharmacotherapy for African American Smokers Completed · 10 cited
  24. Phase 3 Smartphone Based Smoking Cessation Intervention Completed · 8 cited
  25. Phase 4 Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers Completed · 4 cited
  26. Phase 4 Nicotine Replacement Therapy (NRT) Sampling and Selection to Increase Medication Adherence Completed
  27. Phase 3 Comparing NicoBloc to Nicotine Lozenges Completed
  28. Phase 4 STOP Study: Effectiveness of Zyban in a Clinical Population Completed
  29. Phase 4 A Smoking Cessation Intervention for Yale Dining Employees Completed
  30. Phase 4 Progesterone Augmentation of Nicotine Replacement Therapy Study Completed
  31. Phase 4 Nicotine Receptor Density & Response to Nicotine Patch: Pt 2 Extended Treatment Completed
  32. Phase 4 Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families Completed
  33. Phase 4 Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking Completed
  34. Phase 4 Varenicline Light Smoking Pilot Completed
  35. Phase 4 Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients Completed
  36. Phase 4 Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment Completed
  37. Phase 4 Varenicline OTC Trial on Efficacy and Safety Completed
  38. Phase 4 Testing Integrative Smoking Cessation for HIV Patients Completed
  39. Phase 4 Health Systems Reach Interventions Project Completed
  40. Phase 4 Tobacco Treatment Comparison for Cancer Care Completed
  41. Phase 4 Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary Care Completed
  42. Phase 4 Treating Caregivers Who Smoke at AFCH Completed
  43. Phase 4 Identifying Treatments to Motivate Smokers to Quit Completed
  44. Phase 4 A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction Completed

Showing the 50 most-cited and recently-updated of 266 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review of 127 studies shows psychosocial interventions improve smoking cessation in pregnancy
Psychiatry Sys. Review
Systematic review of 127 studies shows psychosocial interventions improve smoking cessation in pregnancy Simple Support Helps Pregnant Women Quit Smoking, Study Shows
This systematic review and meta-analysis of 127 studies involving 47,361 participants evaluates psychosocial interventions for pregnant wome…
Supporting pregnant women to quit smoking with counseling or financial help can lead to healthier babies and fewer NICU admissions.
Cochrane Apr 21, 2026
Report describes U.S. adults' intent and methods for smoking cessation
Infectious Disease
Report describes U.S. adults' intent and methods for smoking cessation Report examines how U.S. adults plan to quit smoking, but findings are not yet available
An observational report describes smoking cessation intentions and methods among U.S.
A new report looks at how U.S. adults plan to quit smoking, but the specific findings have not been released yet.
CDC Apr 4, 2026
Phase 2 Trial: Cytisine and ASA for Inflammation in Lifelong Smokers
Pulmonology & Critical Care Phase II
Phase 2 Trial: Cytisine and ASA for Inflammation in Lifelong Smokers Can quitting smoking and changing your diet really reduce lung inflammation?
A Phase 2 trial evaluates cytisine for smoking cessation and ASA for inflammation in 2000 lifelong smokers.
Quitting smoking, eating better, and moving more can reduce lung inflammation in lifelong smokers, offering a path to breathe easier and low…
CT.gov Mar 28, 2026

Questions about Smoking Cessation

What methods do U.S. adults use to quit smoking based on the report?

U.S. adults use a mix of medications like nicotine replacement therapy and counseling, as well as behavioral methods like stopping cold turkey or cutting down, to quit smoking.

Full answer →
Do psychosocial interventions help pregnant women stop smoking according to the review?

Psychosocial interventions like counseling and social support help pregnant women stop smoking, with strong evidence from recent reviews showing improved abstinence rates.

Full answer →