Phase 3
Completed N=143
Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Smoking Cessation · Alcohol-Related Disorders
Source: ClinicalTrials.gov NCT00304707 ↗
Enrolled (actual)
143
Serious AEs
0.0%
Results posted
May 2017
Primary outcomePrimary: Smoking Abstinence — 19; 21; 12; 9 participants
◆ Published Evidence
Established
95citations · ~32 / year
Antidepressants for smoking cessation.
Summary
Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking. The purpose of this study is to evaluate the effectiveness of bupropion, an antidepressant medication, in treating smokers receiving treatment for alcohol dependence.
Linked Publications
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Antidepressants for smoking cessation.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Smoking Abstinence |
19; 21; 12; 9; 6; 11 | — |
Eligibility Criteria
Inclusion Criteria
- Smokes a minimum of 10 cigarettes daily for at least 1 year prior to study entry
- Abstinence from alcohol and other non-nicotine drugs for between 1 and 12 months at time of study entry
- Meets criteria for alcohol dependence or abuse in the 12 months prior to study entry
Exclusion Criteria
- History of seizures, head trauma and/or severe hepatic cirrhosis
- Current use of medications known to affect smoking behavior and/or cessation
- Use of tricyclic antidepressant medication and monoamine oxidase inhibitors
- Major depressive disorder within the month prior to study entry
- Eating disorder within the year prior to study entry
- History of bipolar or psychotic disorder
- Pregnant or breastfeeding
- Unstable serious medical disorder
- History of migraines
- Currently using smokeless tobacco, pipes, or cigars
Data sourced from ClinicalTrials.gov (NCT00304707) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.