Phase 3
N=194
Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain
Acute Pain
Bottom Line
View on ClinicalTrials.gov: NCT00305058 ↗Enrolled (actual)
194
Serious AEs
0.0%
Results posted
Aug 2018
Primary outcome: Primary: Change in Pain Intensity — 3.3; 3.8 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- Morphine (Drug); Hydromorphone (Drug)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- Montefiore Medical Center
- Primary completion
- Mar 2007
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Pain Intensity |
3.3; 3.8 | — |
| SECONDARY Number of Participants With a Change in Pain Score |
53; 53; 37; 40 | — |
| SECONDARY Number of Participants With Pain Relief |
37; 32; 53; 61 | — |
| SECONDARY Number of Participants Satisfied With Pain Medication |
56; 59; 34; 34 | — |
Summary
The purpose of this research study is to determine which opiate pain medication (morphine or hydromorphone (Dilaudid)) is more effective in the treatment of acute pain in patients presenting to the emergency department.
Eligibility Criteria
Inclusion Criteria
- Age greater than 65 years
- Pain with onset within 7 days
- ED attending physician's judgment that patient's pain warrants use of parenteral opioids
- Normal mental status
Exclusion Criteria
- Prior use of methadone
- Use of other opioids or tramadol within past seven days
- Prior adverse reaction to morphine or hydromorphone
- Chronic pain syndrome
- Alcohol intoxication
- Systolic Blood Pressure <90 mm Hg
- Use of monoamine oxidase (MAO) inhibitors in past 30 days
- Elderly patients with a capnometry reading of greater than 46
Data sourced from ClinicalTrials.gov (NCT00305058). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.