Phase 3
Completed N=194
Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain
Source: ClinicalTrials.gov NCT00305058 ↗Enrolled (actual)
194
Serious AEs
0.0%
Results posted
Aug 2018
Primary outcomePrimary: Change in Pain Intensity — 3.3; 3.8 units on a scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The purpose of this research study is to determine which opiate pain medication (morphine or hydromorphone (Dilaudid)) is more effective in the treatment of acute pain in patients presenting to the emergency department.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Pain Intensity |
3.3; 3.8 | — |
| SECONDARY Number of Participants With a Change in Pain Score |
53; 53; 37; 40 | — |
| SECONDARY Number of Participants With Pain Relief |
37; 32; 53; 61 | — |
| SECONDARY Number of Participants Satisfied With Pain Medication |
56; 59; 34; 34 | — |
Eligibility Criteria
Inclusion Criteria
- Age greater than 65 years
- Pain with onset within 7 days
- ED attending physician's judgment that patient's pain warrants use of parenteral opioids
- Normal mental status
Exclusion Criteria
- Prior use of methadone
- Use of other opioids or tramadol within past seven days
- Prior adverse reaction to morphine or hydromorphone
- Chronic pain syndrome
- Alcohol intoxication
- Systolic Blood Pressure <90 mm Hg
- Use of monoamine oxidase (MAO) inhibitors in past 30 days
- Elderly patients with a capnometry reading of greater than 46
Data sourced from ClinicalTrials.gov (NCT00305058). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.