N/A N=37 Randomized Diagnostic

Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia

Ventilator-Associated Pneumonia

Bottom Line

View on ClinicalTrials.gov: NCT00319644 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2012

Primary outcome: Primary: Change in Antibiotic Usage or Exposure — 11.87; 7.76 days — p=0.26

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Bronchoalveolar lavage (Device)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of California, San Francisco
Primary completion: Dec 2008

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Antibiotic Usage or Exposure	11.87; 7.76	0.26
PRIMARY Antibiotics Exposure Days	4; 5.81	—

Summary

The proposed study will evaluate adult patients admitted to the medical or surgical intensive care units (ICUs) at San Francisco General Hospital (SFGH). On admission, patients will be randomized in a 1:1 manner to the mini-bronchoalveolar lavage (BAL) quantitative culture arm in the setting of suspected ventilator-associated pneumonia (VAP) versus the tracheal aspirate culture arm, which is the current test available at SFGH.

Eligibility Criteria

Inclusion Criteria

All adult patients (> age 18) admitted to 5E, 5R, and 4E intensive care units and are on the ventilator for greater than 48 hours and expected to remain on the ventilator for awhile
Study procedures would be performed only in patients clinically suspected of having VAP.

Exclusion Criteria

Severe respiratory distress at the time of suspected VAP defined by:
FiO2 ≥ 0.7
PEEP ≥ 12

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Data sourced from ClinicalTrials.gov (NCT00319644). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.