Inhaled antibiotics may improve lung function and microbiological eradication in cystic fibrosis and bronchiectasis
Inhaled Antibiotics May Improve Lung Health in Chronic Lung Conditions
This meta-analysis evaluated the efficacy of inhaled antibiotics for patients with cystic fibrosis, non-cystic fibrosis bronchiectasis, and …
Inhaled antibiotics may improve lung function and clear infections for people with cystic fibrosis and other chronic lung conditions.
Antibiotic exposure disrupts gut microbiota in 58% to 94% of critically ill children
Antibiotics and gut health in critically ill children
This narrative review examines antibiotic exposure in critically ill children in the PICU, reporting that 58% to 94% receive antibiotics, wh…
Common antibiotics used in intensive care can disrupt a child's gut health, increasing the risk of serious infections like pneumonia.
Impact of Systemic Prophylactic Antibacterials on Ventilator Associated Pneumonia in ICU Patients
Antibacterials may lower pneumonia rates in patients on ventilators
Meta-analysis data suggests systemic prophylactic antibacterials significantly reduce the incidence of ventilator-associated pneumonia in IC…
A large review suggests that using certain medications can help prevent lung infections in patients requiring breathing machines in the ICU.
Brain-Lung-Immune-Microbiome Axis replaces biomechanical models in understanding ventilator-associated pneumonia after traumatic brain injury
New Framework Explains Lung Infections After Brain Injuries
This narrative review explores the transition from a traditional biomechanical model of ventilator-associated pneumonia to a multidimensiona…
A new model suggests that brain injuries create a complex immune and microbiome response that leads to lung infections in intensive care pat…
Inhaled antibiotics improve clinical cure and reduce mortality in ventilator-associated pneumonia
Inhaled antibiotics help cure pneumonia and lower death risk in ICU patients
This systematic review and meta-analysis of adjunctive inhaled antibiotics for ventilator-associated pneumonia found significantly improved …
Adding inhaled antibiotics to standard care improved cure rates and reduced death in patients with ventilator-associated pneumonia.
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury
Short Antibiotics Cut Early Lung Infections in Brain Injury Patients
This systematic review and meta-analysis evaluated short-course systemic beta-lactam antibiotic prophylaxis versus control in 1,673 mechanic…
Short antibiotic courses cut early lung infections in brain injury patients on ventilators, reducing hospital stays without increasing death…
Pharmacist-led stewardship improved antibiotic appropriateness and outcomes in adult HAP or VAP patients
Can a pharmacist-led program make antibiotic use safer and more effective for pneumonia patients?
This randomized controlled trial evaluated a pharmacist-led antimicrobial stewardship program in 699 adult patients with hospital-acquired o…
A pharmacist-led program significantly improved antibiotic prescriptions and reduced unnecessary drug exposure for pneumonia patients in a h…
Research across Pneumonia
Related studies from across the Pneumonia family.
EV-D68 infection may cause plastic bronchitis and severe pneumonia in pediatric patients
EV-D68 Infection Linked to Severe Lung Issues in Children
This case report and literature review describes a single 11-year-old girl with Enterovirus D68 infection leading to plastic bronchitis and …
A new case report identifies Enterovirus D68 as a potential cause of severe pneumonia and plastic bronchitis in children.
Short-course antibiotic therapy reduces medication non-adherence in children with non-severe community-acquired pneumonia
Short antibiotic courses may help children finish their full prescriptions
This meta-analysis of 10 trials (n = 8970) found that short-course antibiotic therapy (≤ 5 days) for non-severe pediatric community-acquired…
Shorter antibiotic courses for mild pneumonia in children may help them stay on track with their medication without reducing treatment succe…
Higher baseline Prognostic Nutritional Index reduces mortality risk in sepsis and pneumonia patients
Nutritional status helps predict survival in patients with severe infections
This meta-analysis of 28,757 patients with infectious diseases found that higher baseline Prognostic Nutritional Index (PNI) is associated w…
A high nutritional score at the start of treatment can help doctors identify which patients with sepsis or pneumonia are at the highest risk…
Omadacycline and baloxavir marboxil used in an 89-year-old with influenza A, psittacosis, and Klebsiella pneumonia
New drug combination helps elderly man with severe lung infections
This case report describes an 89-year-old man with influenza A, Chlamydia psittaci pneumonia, and Klebsiella pneumoniae who improved and was…
A combination of omadacycline and baloxavir marboxil helped an 89-year-old man recover from a complex, multi-organ infection in the ICU.
Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF
Lung cancer can mimic autoimmune lung disease in some patients
This case report describes a 78-year-old female with invasive mucinous adenocarcinoma and interstitial pneumonia with autoimmune features. T…
A new case shows how a rare lung cancer can look like an autoimmune disease, making it hard for doctors to tell them apart.
MRSA nares PCR does not cut vancomycin duration in ICU CAP
MRSA Testing Does Not Reduce Vancomycin Use in Pneumonia Patients
In a single-center randomized trial of 277 adult ICU patients with suspected community-acquired pneumonia, MRSA nares PCR testing did not si…
A trial of 277 ICU patients found that MRSA nasal swab testing did not reduce the amount of vancomycin used for pneumonia.
Physical frailty tops risk factors for pneumonia after esophagectomy, meta-analysis finds
Physical frailty and muscle loss increase pneumonia risk after surgery
This meta-analysis of 60 cohort studies in esophageal cancer patients undergoing esophagectomy identified physical frailty as the highest-ra…
Patients with esophageal cancer face a higher risk of pneumonia after surgery if they show signs of physical frailty or muscle loss.
Short-course ceftriaxone reduces hospital stay and adverse events in children with pneumonia
Shorter antibiotic courses may help children with pneumonia stay home
This randomized controlled trial of 200 children aged 1 to 14 years found that short-course ceftriaxone (5 to 7 days) resulted in shorter ho…
A new trial shows that a shorter course of ceftriaxone can reduce hospital stays and side effects for children with pneumonia.
Aerosolized liposomal amphotericin B provides strongest evidence for invasive pulmonary aspergillosis prophylaxis in high-risk patients
Aerosolized Amphotericin B Shows Promise for Lung Fungal Infections
This mini review synthesizes clinical experience regarding aerosolized antifungal therapies for various pulmonary fungal infections. It conc…
Aerosolized liposomal amphotericin B shows promise for preventing specific lung fungal infections in high-risk and immunocompromised patient…
mNGS achieves 85.83% pathogen detection rate in children with severe pneumonia compared to 49.97% for conventional methods
New Genetic Test Finds More Pneumonia Germs in Kids
This systematic review evaluates metagenomic next-generation sequencing (mNGS) for identifying pathogens in children with severe pneumonia. …
A new genetic test detects pneumonia-causing germs in kids more often than standard methods, which could lead to better treatment.
iNKT cell activators show promise in preclinical models for stroke-associated pneumonia immunomodulation
New immune treatments show promise for stroke and pneumonia
This systematic review of 38 preclinical studies examines the immunopathology of stroke-associated pneumonia (SAP) and the role of immunomod…
Researchers identify how stroke triggers immune failure and find a promising new way to protect the lungs from pneumonia infections.
IL-6 overexpression linked to alveolar damage in severe pneumonia on ventilation
IL-6 Levels Linked to Lung Damage in Severe Pneumonia
This narrative review synthesizes basic and clinical evidence on IL-6 in mechanically ventilated patients with severe pneumonia. It finds th…
High levels of a protein called IL-6 may be linked to increased lung damage and inflammation in patients with severe pneumonia.
Questions about ventilator-associated pneumonia
Do inhaled antibiotics improve clinical cure rates for ventilator-associated pneumonia?
The available sources do not directly test inhaled antibiotics for ventilator-associated pneumonia, so no firm conclusion can be drawn from them.
Full answer →What is the new brain-lung-immune-microbiome model for understanding ventilator-associated pneumonia?
The Brain-Lung-Immune-Microbiome axis model explains ventilator-associated pneumonia (VAP) as a result of systemic immune failure and gut bacteria moving to the lungs, rather than just a mechanical issue with breathing tubes.
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