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Home › Conditions › ventilator-associated pneumonia

Ventilator-associated pneumonia

Part of Pneumonia

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for ventilator-associated pneumonia

20 trials tracked for ventilator-associated pneumonia: 5 in phase 3 or 4 and 2 with published results. The most-cited published study has 151 citations.

20Trials tracked
5Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 3 Phase 1 1 Other / NA 11
  1. Phase 3 Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008) Completed · 151 cited
  2. Phase 3 A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria. Completed · 108 cited
  3. Phase 4 Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults Completed
  4. Phase 4 A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections Completed
  5. Phase 4 PROUD Study: A Prospective Study on the Usage Patterns of Doripenem in the Asia Pacific Region Completed
  6. Phase 2 An Effectiveness, Safety, and Microbiology Study of Doripenem in Patients With Nosocomial (Hospital-acquired) Pneumonia Completed
Show 14 more trials
  1. Phase 2 Strategies To Prevent Pneumonia 2 (SToPP2) Completed
  2. Phase 2 A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia Completed
  3. Phase 1 Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates Completed
  4. N/A Pilot Study of Lateral Rotation Interventions for Efficacy and Safety in ICU Care Completed
  5. N/A Effect of Angulus on Patient-elevation Compliance Completed
  6. N/A Efficacy Study of a Novel Device to Clean the Endotracheal Tube Completed
  7. N/A Safe Critical Care: Testing Improvement Strategies Completed
  8. N/A Differences in Morbidity Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning Completed
  9. N/A Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia Completed
  10. N/A Efficacy Study on Silver-coated ETT Cleaned With a Novel Device Completed
  11. N/A Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit Completed
  12. N/A The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia. Completed
  13. N/A A Efficacy and Safety Study of Nasal Prongs With Proprietary Surface Coating Aiming to Reduce Bacterial Colonization Completed
  14. N/A Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma Completed

Showing the 20 most-cited and recently-updated of 20 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Ventilator-associated pneumonia: what the trials found

Pharmacological management of ventilator-associated pneumonia includes several agents with documented clinical outcomes. Zavicefta (Ceftazidime-Avibactam) demonstrated a clinical cure rate of 59.3% in the mMITT population and 66.7% at end-of-treatment compared to 25.9% and 29.6%, respectively, in the comparator group 2. ATM-AVI showed clinical cure rates of 68.4% (ITT) and 72.9% (Micro-ITT) compared to 65.7% and 72.3% in its respective comparison groups 6.

Ceftolozane/tazobactam was evaluated for mortality, showing a 24.0% all-cause mortality rate at day 28 in the ITT population compared to 25.3% in the comparator group 5. Clinical response and cure rates for this intervention were approximately equal between groups (54.4% vs 53.3%) 5.

Doripenem was evaluated in multiple trials; clinical response at end-of-treatment varied across study arms, with results ranging from 20.8% to 71.2% 3. Clinical outcomes for doripenem also included data on APACHE II scores and rates of ICU or hospital readmission within 28 days post-treatment 4.

Infection control measures include the use of chlorhexidine gluconate, which was associated with a significantly lower incidence of nosocomial infections (15% vs 30%, p=0.049) and similar ICU lengths of stay [17, 18]. Additionally, ETT cleaning maneuvers were established as an intervention 13, and high-definition CT imaging was used to assess occlusion of extubated tubes 14.

Recent results — preliminary, needs further review

  • Comprehensive Oral Care is currently being evaluated in a new study 1.

For the clinician treating this condition

  • Zavicefta and ATM-AVI demonstrated higher clinical cure rates compared to their respective control groups in patients with ventilator-associated pneumonia.
  • Chlorhexidine gluconate significantly reduced the incidence of nosocomial infections compared to standard care.
  • Ceftolozane/tazobactam showed comparable mortality and clinical cure rates to its comparator group.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Brain-Lung-Immune-Microbiome Axis replaces biomechanical models in understanding ventilator-associated pneumonia after traumatic brain injury
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Brain-Lung-Immune-Microbiome Axis replaces biomechanical models in understanding ventilator-associated pneumonia after traumatic brain injury New Framework Explains Lung Infections After Brain Injuries
This narrative review explores the transition from a traditional biomechanical model of ventilator-associated pneumonia to a multidimensiona…
A new model suggests that brain injuries create a complex immune and microbiome response that leads to lung infections in intensive care pat…
Frontiers Jul 16, 2026
Inhaled antibiotics improve clinical cure and reduce mortality in ventilator-associated pneumonia
Infectious Disease Meta-analysis
Inhaled antibiotics improve clinical cure and reduce mortality in ventilator-associated pneumonia Inhaled antibiotics help cure pneumonia and lower death risk in ICU patients
This systematic review and meta-analysis of adjunctive inhaled antibiotics for ventilator-associated pneumonia found significantly improved …
Adding inhaled antibiotics to standard care improved cure rates and reduced death in patients with ventilator-associated pneumonia.
Jun 4, 2026
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury
Infectious Disease Meta-analysis
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury Short Antibiotics Cut Early Lung Infections in Brain Injury Patients
This systematic review and meta-analysis evaluated short-course systemic beta-lactam antibiotic prophylaxis versus control in 1,673 mechanic…
Short antibiotic courses cut early lung infections in brain injury patients on ventilators, reducing hospital stays without increasing death…
Apr 14, 2026
Pharmacist-led stewardship improved antibiotic appropriateness and outcomes in adult HAP or VAP patients
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Pharmacist-led stewardship improved antibiotic appropriateness and outcomes in adult HAP or VAP patients Can a pharmacist-led program make antibiotic use safer and more effective for pneumonia patients?
This randomized controlled trial evaluated a pharmacist-led antimicrobial stewardship program in 699 adult patients with hospital-acquired o…
A pharmacist-led program significantly improved antibiotic prescriptions and reduced unnecessary drug exposure for pneumonia patients in a h…
Frontiers Apr 9, 2026

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