N/A
Completed N=71
An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa
Source: ClinicalTrials.gov NCT00345943 ↗Enrolled (actual)
71
Serious AEs
0.0%
Results posted
Dec 2021
Primary outcomePrimary: Magnetic Resonance Imaging Scans — 2.98; 2.96 mm — p=.03
Summary
The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Magnetic Resonance Imaging Scans |
2.98; 2.96 | .03 sig |
| SECONDARY Conners Continuous Performance Test-II (CPT-II) |
49.52; 53.24; 53.31; 50.20; 39.71; 45.57 | — |
| SECONDARY Stroop Word-Color Interference |
22.1; 21.5 | — |
| SECONDARY Weather Prediction Task |
54.9; 51.4 | — |
Eligibility Criteria
Inclusion Criteria
- Current or prior DSM IV diagnosis of Bulimia Nervosa or Sub-threshold Bulimia Nervosa (those who meet all DSM-IV criteria for BN, but engage in subjective binge-eating episodes and binge/purge at a frequency of at least once per week for 3 months, whereas meeting full DSM-IV criteria for BN requires binge eating and purging twice per week for 3 months)
- Major Depression
- For control adolescents, no current or past history of an eating disorder
Exclusion Criteria
- Ferromagnetic implants (e.g., pacemaker)
- Metal braces or retainers
- IQ less than 80
- Any other current major Axis I disorder, other than major depressive disorder (MDD)
- History of concussion, seizure disorder, or other neurological illness
- Claustrophobia
- Pregnant
Data sourced from ClinicalTrials.gov (NCT00345943). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.