N/A
N=1,250
Characteristics and Prevalence of Tuberculosis and HIV in Masiphumelele Township, Cape Town, South Africa
HIV Infections · Tuberculosis
Bottom Line
View on ClinicalTrials.gov: NCT00346476 ↗Enrolled (actual)
1,250
Serious AEs
0.0%
Results posted
Feb 2011
Primary outcome: Primary: Number of Participants With Microbiologically Confirmed Tuberculosis Infection — 20 participants
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Pediatric, Adult, Older Adult · 15+ yrs
- Sex
- All
- Sponsor
- CIPRA SA
- Primary completion
- Dec 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Microbiologically Confirmed Tuberculosis Infection |
20 | — |
| PRIMARY Number of Participants With HIV Infection |
306 | — |
| SECONDARY Changes in Clustering and Transmission of TB Among HIV Infected and Uninfected Participants |
— | — |
| SECONDARY Changes in the Clustering and Transmission of TB Among HIV Infected and Uninfected Participants After the Introduction of HAART |
— | — |
| SECONDARY Diversity of TB Strains Among HIV Infected Participants Receiving HAART, HIV Infected Participants Not Receiving HAART, and HIV Uninfected Participants |
— | — |
| SECONDARY Number of Recurrent Cases of TB Attributable to Endogenous Reactivation Versus Exogenous Re-infection in Both HIV Infected and Uninfected Participants |
— | — |
Summary
The purpose of this study is to determine the number of people infected with tuberculosis (TB) in the Masiphumelele Township of Cape Town, South Africa, a community with high rates of TB and HIV. This study will also examine the genetics of TB and the relationships among active TB infection, new HIV infections, and HIV disease progression.
Eligibility Criteria
Inclusion Criteria for All Participants:
- Willing to comply with study requirements
- Parent or guardian willing to provide informed consent, if applicable
Inclusion Criteria for Participants in First Part of the Study:
- Live in Masiphumelele Township, Cape Town, South Africa for at least 1 week
Inclusion Criteria for Participants in Second Part of the Study:
- Live in Masiphumelele Township, Cape Town, South Africa
- Registered TB patient at the study site
Exclusion Criteria for All Participants:
- Currently incarcerated
Exclusion Criteria for Participants in Second Part of the Study:
- No Mycobacterium tuberculosis specimen obtained from the participant for genetic analysis
Data sourced from ClinicalTrials.gov (NCT00346476). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.