Phase 2
Completed N=43
Clonidine-induced Spinal Acetylcholine Release: Normal Volunteers vs. Neuropathic Pain
Source: ClinicalTrials.gov NCT00350532 ↗Enrolled (actual)
43
Serious AEs
0.0%
Results posted
Sep 2009
Primary outcomePrimary: Acetylcholine Concentration in Cerebrospinal Fluid — 406; 383 picograms per milliliter (pg/ml)
Summary
The purpose of this study is to compare the amount of acetylcholine release after a single injection of clonidine in normal volunteers and individuals with neuropathic pain.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Acetylcholine Concentration in Cerebrospinal Fluid |
406; 383 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy adult volunteers
- Patients with neuropathic pain
Exclusion Criteria
- Pregnancy
- Allergy to clonidine
- Currently taking clonidine or other direct a2-adrenergic agonists
- Taking cholinesterase inhibitors
Data sourced from ClinicalTrials.gov (NCT00350532). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.