Phase 3
Completed N=727
Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
Source: ClinicalTrials.gov NCT00358579 ↗Enrolled (actual)
727
Serious AEs
—
Results posted
Aug 2011
Primary outcomePrimary: Survival to Hospital Discharge. — 8; 11 Participants
Summary
The effectiveness of medications in cardiac arrest has been greatly debated and questioned. Historically intravenous adrenaline has been the drug of choice since 1906. There have been few formal evaluations to determine the value of adrenaline for cardiac arrest, and clinical trials have not been able to show any benefit with intravenous adrenaline (compared to placebo or no treatment) in the field.
Thus the purpose of this study is to compare vasopressin and adrenaline in the treatment of cardiac arrest to answer the question whether there is an improvement in survival between vasopressin and adrenaline.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Survival to Hospital Discharge. |
8; 11 | — |
| SECONDARY Neurological Status on Discharge or at 30 Days Post Arrest, if Not Discharged. |
5; 4; 0; 1; 2; 5 | — |
| SECONDARY Neurological Status at 1 Year. |
5; 4; 0; 1; 3; 3 | — |
| SECONDARY Return of Spontaneous Circulation. |
106; 119 | — |
| SECONDARY Survival to Admission. |
59; 83 | — |
Eligibility Criteria
Inclusion Criteria
- Patient with cardiac arrest as confirmed by the absence of a pulse, unresponsiveness and apnea
- Age above 16 (Age 21 and above for CGH only)
Exclusion Criteria
- Traumatic cardiac arrest
- Age 16 and below (Age 20 and below for CGH only)
- CPR is contraindicated
Data sourced from ClinicalTrials.gov (NCT00358579). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.