N/A
N=40
Tai Chi Mind-Body Therapy for Knee Osteoarthritis
Knee Osteoarthritis
Bottom Line
View on ClinicalTrials.gov: NCT00362453 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Feb 2010
Primary outcome: Primary: Change in the Western Ontario and McMaster University Index (WOMAC) Pain Subscale Between Baseline and 12 Weeks — -157.25; -38.45 mm — p=0.0005
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Tai Chi versus Attention Control (Behavioral)
- Age
- Adult, Older Adult · 55+ yrs
- Sex
- All
- Sponsor
- Tufts Medical Center
- Primary completion
- Mar 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in the Western Ontario and McMaster University Index (WOMAC) Pain Subscale Between Baseline and 12 Weeks |
-157.25; -38.45 | 0.0005 sig |
| SECONDARY Change in WOMAC Function From Baseline to 12, 24, and 48 Weeks. |
-506.75; -182.15; -440.50; -257.30; -405.85; -300.55 | 0.001 sig |
| SECONDARY Change in WOMAC Stiffness From Baseline to 12, 24, and 48 Weeks. |
-73.05; -50.15; -65.00; -50.20; -64.15; -60.50 | 0.1 |
| SECONDARY Change in WOMAC Pain Scores From Baseline to 24 and 48 Weeks. |
-131.55; -64.60; -115.35; -69.20 | 0.05 |
| SECONDARY Change in Patient Global Knee Pain Assessment Visual Analogue Scale (VAS) |
-2.98; -0.83; -2.36; -1.71; -1.65; -1.70 | 0.01 sig |
| SECONDARY Change in Physician Global Knee Pain Assessment Visual Analogue Scale (VAS)From Baseline to 12, 24, and 48 Weeks. |
-3.14; -1.44; -2.59; -2.06; -2.53; -1.50 | 0.002 sig |
| SECONDARY Change in Timed Chair Stand From Baseline to 12, 24, and 48 Weeks. |
-12.03; -1.15; -9.87; -4.75; -9.22; -3.24 | 0.00005 sig |
| SECONDARY Change in 6 Minute Walk Test From Baseline to 12, 24, and 48 Weeks. |
48.33; -1.76; 53.12; 9.41; 35.17; 20.56 | 0.1 |
| SECONDARY Change in Standing Balance From Baseline to 12, 24, and 48 Weeks. |
0.15; 0.25; 0.15; 0.08; 0.35; 0.46 | 0.7 |
| SECONDARY Change in Center for Epidemiology Studies Depression Index (CES-D)From Baseline to 12, 24, and 48 Weeks. |
-7.40; -0.70; -6.40; -1.10; -7.25; 1.65 | 0.009 sig |
| SECONDARY Change in Self-Efficacy Scale From Baseline to 12, 24, and 48 Weeks. |
0.60; -0.11; 0.68; -0.17; 0.72; -0.24 | 0.04 sig |
| SECONDARY Change in Medical Outcome Study Short Form 36 (SF-36) Physical Component From Baseline to 12, 24, and 48 Weeks. |
11.57; 4.14; 10.80; 6.29; 10.41; 4.10 | 0.004 sig |
| SECONDARY Change in Medical Outcome Study Short Form 36 (SF-36) Mental Component |
2.14; 1.93; 4.39; 4.50; 5.80; 1.04 | 0.9 |
Summary
The purpose of this study was to compare the safety and effectiveness of Tai Chi with an Attention Control intervention consisting of a stretching and wellness education program involving 40 patients with osteoarthritis (OA) of the knee. We hypothesized that the participants receiving Tai Chi would show greater improvement in knee pain, physical and psychological functioning, and health-related quality of life than participants in the Attention Control group, and that the benefit would be mediated by effects on muscle function, musculoskeletal flexibility and mental health.
Eligibility Criteria
Inclusion Criteria
- Age 55 or older
- Body Mass Index (BMI) = 40 (visual analog version)
- Physically able to participate in both the Tai Chi and stretching and education programs
- Willing to complete the 12-week study, including twice a week Tai Chi or stretching and education sessions
- Willing to abstain from Tai Chi until completion of the program, if randomized to the stretching and education sessions
- Willing to abstain from stretching and education sessions until completion of the program, if randomized to Tai Chi
Exclusion Criteria
- Prior experience with Tai Chi or other similar types of Complementary and Alternative Medicine such as Qi gong, yoga, and acupuncture since these share some of the principles of Tai Chi
- Dementia, neurological disease, cardiovascular disease, pulmonary disease, metabolic disease, renal disease, liver disease, or other serious medical conditions limiting ability to participate in either the Tai Chi or stretching programs as determined by primary care physicians
- Any intra-articular steroid injections in the previous 3 months or reconstructive surgery on the affected knee
- Any intra-articular Synvisc or Hyalgan injections in the previous 6 months
- Inability to pass the Mini-Mental Status examination (with a score below 24)
- Enrollment in any other clinical trial within the last 30 days
- Plan to permanently relocate from the region during the trial period
- Non English Speaking
Data sourced from ClinicalTrials.gov (NCT00362453). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.