Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritis
Specific exercise volume and intensity may help manage knee osteoarthritis pain
This meta-analysis of 791 people with knee osteoarthritis found that moderate-intensity isotonic lower extremity resistance exercise signifi…
New research suggests that specific types of resistance exercises can help people with knee osteoarthritis manage pain and improve daily mov…
Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
Nerve Block Combination May Shorten Hospital Stays After Knee Surgery
A randomized trial evaluates whether an eight-nerve block technique reduces opioid consumption and hospital stay compared to standard LIA.
A new nerve block technique for knee replacement patients showed lower opioid use and shorter hospital stays compared to standard local inje…
Deep-learning models show variable sensitivity and precision for knee osteoarthritis grading
Deep Learning Shows Promise Grading Knee Osteoarthritis
This meta-analysis of 32 studies evaluated deep-learning (DL) algorithms for radiographic grading of knee osteoarthritis (KOA). Pooled sensi…
AI shows promise grading knee OA on X-rays, but it's not ready for early-stage detection, a new review finds.
Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis
Ozone injections may reduce knee pain more than corticosteroids
This meta-analysis of 409 patients compared intra-articular ozone injections to corticosteroid injections for knee osteoarthritis. The analy…
Ozone injections could offer a more effective way to manage pain and improve movement for people living with knee osteoarthritis.
Robotic-assisted TKA using functional alignment principles yields favorable outcomes and low early revision risk
Robotic assistance improves outcomes for patients with knee osteoarthritis
This systematic review and meta-analysis of 5155 patients evaluated robotic-assisted TKA using functional alignment (FA) principles. The ana…
Robotic-assisted knee replacements using functional alignment show improved movement and lower early revision risks for patients with knee o…
CT-based CPAK measurements show more varus MPTA and valgus LDFA than LLR
CT Scans Show Different Knee Alignment Than X-rays
This retrospective cohort study of 241 patients undergoing robotic-assisted total knee arthroplasty compared CT and long-leg radiograph (LLR…
New analysis shows that CT scans and traditional X-rays can produce different alignment measurements for patients undergoing knee replacemen…
Infection, instability, and aseptic loosening are the primary causes of revision TKA failure
Analysis reveals common reasons for failed revision knee replacements
This meta-analysis of 39,723 revision arthroplasties identified a re-revision rate of 13.5%. The study highlights infection as the most freq…
A large-scale analysis of over 39,000 surgeries identifies infection and instability as leading causes of failure in revised knee replacemen…
VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis
Virtual reality helps manage knee osteoarthritis pain and function
This systematic review and meta-analysis found that virtual reality (VR)-assisted physiotherapy significantly improves pain, physical functi…
Using virtual reality during physical therapy can provide better pain relief and improved balance for people with knee osteoarthritis.
Celecoxib ranks highest for analgesic efficacy in patients with knee osteoarthritis
Comparing Different Medications and Supplements to Manage Knee Osteoarthritis Pain
This network meta-analysis compared several interventions, including celecoxib, metformin, and krill oil, for the management of knee osteoar…
Doctors are looking at several ways to treat knee pain. This review compares drugs like celecoxib with natural options like krill oil.
Mongolian warm acupuncture improves clinical response in knee osteoarthritis vs oral meds
Mongolian Medicines Warm Acupuncture Shows Promise for Knee Osteoarthritis
This meta-analysis of 882 patients with knee osteoarthritis found that Mongolian medicines warm acupuncture significantly improved clinical …
A review of clinical trials suggests that Mongolian medicines warm acupuncture may improve symptoms for people with knee osteoarthritis.
Neuromodulation techniques show promise for pain and function in knee osteoarthritis, but evidence is low certainty
Neuromodulation Shows Promise for Managing Knee Osteoarthritis Pain
A scoping review of 23 studies (18 RCTs) found that various neuromodulation techniques (TENS, NMES, PNS, electroacupuncture, tDCS) demonstra…
Various electrical stimulation techniques may help manage pain and improve function for people living with knee osteoarthritis.
Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge
Surgeons performing nerve blocks may help patients leave hospital sooner
This randomized controlled trial of 200 patients undergoing total knee arthroplasty found no significant difference in time to discharge bet…
A new trial shows that surgeons performing specific nerve blocks for knee surgery provide similar pain relief and discharge times as anesthe…
Research across Arthritis
Related studies from across the Arthritis family.
Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators
Coumarins may protect bone and joint health in several diseases
This systematic review examines the role of coumarins and their derivatives in managing musculoskeletal diseases including osteoporosis, rhe…
Coumarins and their derivatives may slow the progression of bone and joint diseases by targeting inflammation and specific cellular pathways…
Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty
Opioid-free Pain Management Shows Better Results for Hip Surgery Patients
This meta-analysis of 1681 patients found that opioid-free perioperative regimens resulted in lower movement and resting VAS pain scores com…
Patients undergoing hip replacement may experience less pain and fewer side effects when managed with opioid-free medication plans after sur…
Gut microbiota-targeted interventions reduce pain and function scores in patients with osteoarthritis
Gut health treatments may reduce pain for osteoarthritis patients
This meta-analysis of 18 trials involving 2,080 adults with osteoarthritis found that probiotics, prebiotics, and synbiotics significantly r…
Targeting the gut with probiotics and prebiotics may help ease pain and improve physical function for people living with osteoarthritis.
Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis
Tiny particles may offer new hope for osteoarthritis treatment
This systematic review examines the role of extracellular vesicles (EVs) in osteoarthritis, identifying both pathological and therapeutic EV…
Small particles called extracellular vesicles could stop the cycle of joint damage and inflammation in people with osteoarthritis.
Immune signaling and bidirectional neuropeptide release drive nociceptor sensitization in osteoarthritis pain
Immune Signaling and Nerve Activity Drive Osteoarthritis Pain
This mini review explores the mechanisms of synovial inflammation and immune signaling in osteoarthritis. It describes how macrophages, T ce…
New research highlights how immune cells and nerve signals work together to create and amplify chronic pain in people with osteoarthritis.
Interactive remote rehabilitation shows no significant advantage over conventional rehabilitation for post-TKA patients
Interactive remote rehabilitation shows mixed results for knee replacement patients
This meta-analysis of randomized controlled trials involving 2607 adults post-total knee arthroplasty found that interactive remote rehabili…
New research into interactive remote rehabilitation for knee replacements shows it may not offer significant advantages over traditional in-…
Icariin improves pain and cartilage scores in murine osteoarthritis, meta-analysis finds
Icariin Shows Potential to Reduce Osteoarthritis Pain in Mice
This meta-analysis of 13 preclinical studies (238 murine subjects) found that Epimedium-derived botanical metabolites, including icariin, si…
A review of studies on mice suggests that icariin, a compound from the Epimedium plant, may reduce inflammation and pain markers in osteoart…
Multi-trait genome-wide association studies identify 66 novel genetic associations in osteoarthritis using the Trident framework
New genetic analysis finds 66 hidden osteoarthritis signals
This meta-analysis evaluates the use of the Trident framework and Combined-GWAS (C-GWAS) method to identify genetic markers for osteoarthrit…
A new genetic method uncovered 66 hidden osteoarthritis signals, offering fresh clues about the condition and potential new targets for trea…
Inflammaging and immunosenescence emerge as key mechanistic axes in osteoarthritis pathogenesis
Aging and inflammation drive the progression of osteoarthritis
This narrative review synthesizes evidence that inflammaging and immunosenescence are central to osteoarthritis pathogenesis, linking aging,…
New research highlights how aging cells and chronic inflammation work together to break down joint tissue in people with osteoarthritis.
Exosomes are safe for knee osteoarthritis but show no superiority over placebo in one trial
Exosomes for knee arthritis: safe but no better than placebo
This systematic scoping review synthesizes evidence on orthobiologics including platelet-rich plasma, cytokine-rich serum, and extracellular…
A review finds exosome injections for knee osteoarthritis are safe, but one trial shows no advantage over placebo.
Telemedicine modalities may achieve comparable outcomes to conventional follow-up for uncomplicated total joint arthroplasty
Telemedicine may offer similar results for hip and knee replacements
This mini review synthesizes evidence regarding telemedicine modalities, including video consultations and telerehabilitation, for patients …
New evidence suggests that using video calls and remote monitoring for joint replacement recovery can match the quality of traditional in-pe…
Mechanical loading induces innate immune reprogramming and mitochondrial danger signals in osteoarthritis models
Mechanical Loading May Influence Immune Responses in Osteoarthritis
This mini review explores the role of mechanical loading in driving innate immune reprogramming and mitochondrial stress in osteoarthritis. …
New research explores how physical loading affects immune cells and mitochondria in joints affected by osteoarthritis.
Questions about Knee Osteoarthritis
Will a structured rehabilitation program reduce pain in my hip or knee osteoarthritis?
Yes, structured rehabilitation programs like GLA:D reduce pain in hip or knee osteoarthritis, with over half of patients reporting significant improvement.
Full answer →Do intra-articular adipose-derived cell therapies reduce pain without causing serious side effects?
Yes, intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious side effects, based on a systematic review of 19 randomized trials.
Full answer →Are engineered exosomes currently an effective treatment for my knee osteoarthritis?
Engineered exosomes are not yet an effective treatment for knee osteoarthritis; they remain in preclinical research with no human efficacy data.
Full answer →All Knee Osteoarthritis Articles
- Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritis
- Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
- Deep-learning models show variable sensitivity and precision for knee osteoarthritis grading
- Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis
- Robotic-assisted TKA using functional alignment principles yields favorable outcomes and low early revision risk
- CT-based CPAK measurements show more varus MPTA and valgus LDFA than LLR
- Infection, instability, and aseptic loosening are the primary causes of revision TKA failure
- VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis
- Mongolian warm acupuncture improves clinical response in knee osteoarthritis vs oral meds
- Celecoxib ranks highest for analgesic efficacy in patients with knee osteoarthritis
- Neuromodulation techniques show promise for pain and function in knee osteoarthritis, but evidence is low certainty
- AI models show high correlation with physics-based methods to predict peak knee adduction moment
- Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge
- TENS reduces pain (MD -0.82) and improves muscle strength in patients with knee osteoarthritis
- Second-generation bicruciate-retaining TKA shows 5.7% revision rate in meta-analysis
- Tai Chi and Wuqinxi reduce pain while Pilates and Baduanjin improve physical function in knee osteoarthritis
- Exercise therapy significantly improves pain and physical function in elderly patients with knee osteoarthritis
- Probiotics show potential for knee osteoarthritis symptoms but evidence is limited
- Kinematic alignment improves function and pain over mechanical alignment in robotic TKA
- Patellar resurfacing and nonresurfacing show similar 5-year outcomes in total knee arthroplasty
- Systematic review and meta-analysis of Wuqinxi for knee osteoarthritis joint function
- Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response
- Feasibility Review of Portable Markerless Motion Capture for Knee OA
- Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
- Intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious adverse events
- Observational transcriptomic analysis identifies genes associated with knee osteoarthritis severity in older adults
- Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program
- Topical S. officinale preparations show efficacy for acute back pain, knee osteoarthritis, ankle sprains, and myalgia versus placebo
- 7-Year Observational Study Abstract Links BMI and Alignment to Cartilage Loss in Knee Osteoarthritis
- Meta-analysis finds 87% implant survivorship after 10 years in patients under 50 undergoing TKA
- Memantine reduces opioid use but not pain in knee osteoarthritis patients after surgery
- Medial Unicompartmental Knee Arthroplasty Shows Small Advantages Over Total Knee Arthroplasty in Severe Anteromedial Knee Osteoarthritis
- Platelet-rich plasma therapy in knee osteoarthritis patients showed high prediction accuracy for pain reduction
- CT-SMA improves trabecular estimation and OA diagnosis in knee osteoarthritis cohorts
- Meta-analysis finds noninvasive electrical stimulation improves pain and function in knee osteoarthritis
- Otago Exercise Program improves knee function and mobility after total knee arthroplasty in meta-analysis
- Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
- Deep learning reconstruction improves 5.0 Tesla knee MRI quality and diagnostic agreement in 69-patient cohort
- IPFP preservation versus resection in TKA shows no significant difference in 12-month KOOS scores
- Sarcopenic obesity prevalence is 28% in adults with advanced knee OA and severe obesity
- Pain catastrophizing predicts tDCS response patterns in knee osteoarthritis pain
- Mobilization with movement reduces pain and disability in knee osteoarthritis meta-analysis