PRP shows limited structural benefit in knee osteoarthritis, with patellofemoral cartilage and bone marrow edema signals
Platelet-rich plasma shows mixed results for knee osteoarthritis structure
This meta-analysis of 1200 patients with knee osteoarthritis found that platelet-rich plasma (PRP) was associated with greater improvement i…
New data shows platelet-rich plasma may improve specific knee cartilage areas but does not change overall structural disease progression.
Cementless mobile-bearing UKA shows noninferior survivorship and clinical scores to cemented devices
Cementless implants show similar results to cemented knee replacements
This multicenter randomized controlled trial of 378 patients undergoing unicompartmental knee arthroplasty found that cementless mobile-bear…
A new study shows that cementless implants perform just as well as traditional cemented ones for patients with specific knee joint issues.
Patient education combined with exercise reduces pain in knee osteoarthritis patients by MD -3.28
Patient education combined with exercise reduces knee osteoarthritis pain
This meta-analysis evaluates the impact of patient education combined with exercise versus exercise alone for knee osteoarthritis. The analy…
Adding patient education to exercise routines can significantly lower pain for people living with knee osteoarthritis.
Digital support for exercise improves physical function in knee osteoarthritis patients
Different Exercise Styles Show Varying Results for Knee Osteoarthritis
This systematic review and network meta-analysis of 2,250 patients evaluated seven exercise and self-management strategies for knee osteoart…
New research looks at how different types of exercise and digital support impact pain and movement for people with knee osteoarthritis.
Knee osteoarthritis research trends show increasing focus on metabolic syndrome and inflammatory signaling
Mapping the Growth and Future Trends in Knee Osteoarthritis Research
This bibliometric and scientometric analysis of 783 publications from 2000 to 2025 identifies a substantial increase in research output afte…
Experts analyzed years of data to find how scientists are changing the way they treat and study knee joint pain.
Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritis
Specific exercise volume and intensity may help manage knee osteoarthritis pain
This meta-analysis of 791 people with knee osteoarthritis found that moderate-intensity isotonic lower extremity resistance exercise signifi…
New research suggests that specific types of resistance exercises can help people with knee osteoarthritis manage pain and improve daily mov…
Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
Nerve Block Combination May Shorten Hospital Stays After Knee Surgery
A randomized trial evaluates whether an eight-nerve block technique reduces opioid consumption and hospital stay compared to standard LIA.
A new nerve block technique for knee replacement patients showed lower opioid use and shorter hospital stays compared to standard local inje…
Deep-learning models show variable sensitivity and precision for knee osteoarthritis grading
Deep Learning Shows Promise Grading Knee Osteoarthritis
This meta-analysis of 32 studies evaluated deep-learning (DL) algorithms for radiographic grading of knee osteoarthritis (KOA). Pooled sensi…
AI shows promise grading knee OA on X-rays, but it's not ready for early-stage detection, a new review finds.
Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis
Ozone injections may reduce knee pain more than corticosteroids
This meta-analysis of 409 patients compared intra-articular ozone injections to corticosteroid injections for knee osteoarthritis. The analy…
Ozone injections could offer a more effective way to manage pain and improve movement for people living with knee osteoarthritis.
Robotic-assisted TKA using functional alignment principles yields favorable outcomes and low early revision risk
Robotic assistance improves outcomes for patients with knee osteoarthritis
This systematic review and meta-analysis of 5155 patients evaluated robotic-assisted TKA using functional alignment (FA) principles. The ana…
Robotic-assisted knee replacements using functional alignment show improved movement and lower early revision risks for patients with knee o…
CT-based CPAK measurements show more varus MPTA and valgus LDFA than LLR
CT Scans Show Different Knee Alignment Than X-rays
This retrospective cohort study of 241 patients undergoing robotic-assisted total knee arthroplasty compared CT and long-leg radiograph (LLR…
New analysis shows that CT scans and traditional X-rays can produce different alignment measurements for patients undergoing knee replacemen…
Infection, instability, and aseptic loosening are the primary causes of revision TKA failure
Analysis reveals common reasons for failed revision knee replacements
This meta-analysis of 39,723 revision arthroplasties identified a re-revision rate of 13.5%. The study highlights infection as the most freq…
A large-scale analysis of over 39,000 surgeries identifies infection and instability as leading causes of failure in revised knee replacemen…
Research across Arthritis
Related studies from across the Arthritis family.
Immune and chondrocyte ligand-receptor axes drive osteoarthritis progression and offer therapeutic targets
Scientists Map Immune Signals That May Drive Knee Arthritis
This narrative review examines immune-chondrocyte ligand-receptor (LR) axes in osteoarthritis, identifying cytokine, chemokine, DAMP-PRR, an…
A new review maps the immune signals that may push cartilage cells to break down in osteoarthritis, pointing to possible future treatment ta…
Macrophage-fibroblast interactions drive inflammatory amplification and cartilage-degrading enzyme production in osteoarthritis
Cell interactions drive inflammation and tissue damage in osteoarthritis
This mini review examines macrophage-fibroblast interactions in osteoarthritis. Findings suggest that macrophage signals increase fibroblast…
New research reveals how specific cell interactions drive the inflammation and tissue breakdown seen in osteoarthritis.
Telemedicine May Improve Pain and Function in Arthritis Patients
Telemedicine helps manage pain for patients with arthritis conditions
Telemedicine may improve pain, function, and quality of life in osteoarthritis and inflammatory arthritis, but evidence certainty is low.
Telemedicine shows promise in reducing pain and improving quality of life for people living with osteoarthritis and inflammatory arthritis.
Metabolic stress from obesity and hyperglycemia impairs macrophage efferocytosis in osteoarthritis joint environments
Metabolic Stress Linked to Joint Damage in Osteoarthritis
This mini review explores how metabolic stress, specifically obesity and hyperglycemia, impacts macrophage efferocytosis and joint homeostas…
New research identifies how obesity and high blood sugar may impair the body's ability to clear dead cells in joints, potentially worsening …
Non-steroidal anti-inflammatory drugs are a predictably effective first-line pharmacologic therapy for canine osteoarthritis
New guidelines offer a multi-step plan for dog joint pain
This clinical guideline provides a consensus-driven framework for managing osteoarthritis in adult dogs. It identifies non-steroidal anti-in…
New guidelines suggest a mix of nutrition, exercise, and medication to help dogs with osteoarthritis live more comfortable lives.
Kinematic vs Mechanical Alignment in Total Knee Arthroplasty: Similar Outcomes, Higher Preference
Kinematic Alignment Shows Specific Patient Preference in Knee Replacement
Kinematic alignment did not improve reoperation rates or patient-reported outcomes versus mechanical alignment, but bilateral patients prefe…
Patients with both knees replaced may prefer the kinematic alignment technique, even though overall surgical outcomes are similar to standar…
Immune-cell activation and metabolic dysfunction may interact to influence synovial inflammation and cartilage homeostasis in osteoarthritis
Immune and Metabolic Signals Linked to Osteoarthritis
This narrative review explores the interplay between immune and metabolic processes in osteoarthritis. The authors suggest that these intera…
Osteoarthritis may involve a two-way conversation between immune cells and metabolism, a new review suggests.
Ultrasound-guided peripheral nerve blocks provide analgesic benefits for patients with refractory osteoarthritis pain
Ultrasound-guided nerve blocks provide relief for chronic joint pain
This narrative review synthesizes evidence on ultrasound-guided peripheral nerve blocks for refractory osteoarthritis pain. The review indic…
Newer nerve block techniques using ultrasound may offer lasting pain relief for people with severe osteoarthritis that does not respond to s…
Lateral meniscal abnormalities do not significantly impact short- to mid-term outcomes after medial UKA
Lateral Meniscus Injuries May Not Affect Knee Surgery Outcomes
This meta-analysis of 1,709 patients with anteromedial osteoarthritis found that lateral meniscal abnormalities did not significantly impact…
A review of 1,709 patients suggests that certain lateral meniscus issues do not significantly impact recovery after specific knee replacemen…
Robot-assisted total hip arthroplasty associated with improved leg-length accuracy and functional scores
Robots May Help Improve Accuracy in Hip Replacement Surgery
This meta-analysis compared robot-assisted total hip arthroplasty to conventional techniques in patients undergoing hip replacement. The aut…
Robotic assistance during hip replacement surgery is linked to better leg length accuracy and higher patient scores for joint function and c…
Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators
Coumarins may protect bone and joint health in several diseases
This systematic review examines the role of coumarins and their derivatives in managing musculoskeletal diseases including osteoporosis, rhe…
Coumarins and their derivatives may slow the progression of bone and joint diseases by targeting inflammation and specific cellular pathways…
Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty
Opioid-free Pain Management Shows Better Results for Hip Surgery Patients
This meta-analysis of 1681 patients found that opioid-free perioperative regimens resulted in lower movement and resting VAS pain scores com…
Patients undergoing hip replacement may experience less pain and fewer side effects when managed with opioid-free medication plans after sur…
Questions about Knee Osteoarthritis
Will a structured rehabilitation program reduce pain in my hip or knee osteoarthritis?
Yes, structured rehabilitation programs like GLA:D reduce pain in hip or knee osteoarthritis, with over half of patients reporting significant improvement.
Full answer →Do intra-articular adipose-derived cell therapies reduce pain without causing serious side effects?
Yes, intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious side effects, based on a systematic review of 19 randomized trials.
Full answer →Are engineered exosomes currently an effective treatment for my knee osteoarthritis?
Engineered exosomes are not yet an effective treatment for knee osteoarthritis; they remain in preclinical research with no human efficacy data.
Full answer →All Knee Osteoarthritis Articles
- PRP shows limited structural benefit in knee osteoarthritis, with patellofemoral cartilage and bone marrow edema signals
- Patient education combined with exercise reduces pain in knee osteoarthritis patients by MD -3.28
- Cementless mobile-bearing UKA shows noninferior survivorship and clinical scores to cemented devices
- Digital support for exercise improves physical function in knee osteoarthritis patients
- Knee osteoarthritis research trends show increasing focus on metabolic syndrome and inflammatory signaling
- Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritis
- Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
- Deep-learning models show variable sensitivity and precision for knee osteoarthritis grading
- Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis
- Robotic-assisted TKA using functional alignment principles yields favorable outcomes and low early revision risk
- CT-based CPAK measurements show more varus MPTA and valgus LDFA than LLR
- Infection, instability, and aseptic loosening are the primary causes of revision TKA failure
- VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis
- Mongolian warm acupuncture improves clinical response in knee osteoarthritis vs oral meds
- Celecoxib ranks highest for analgesic efficacy in patients with knee osteoarthritis
- Neuromodulation techniques show promise for pain and function in knee osteoarthritis, but evidence is low certainty
- AI models show high correlation with physics-based methods to predict peak knee adduction moment
- Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge
- TENS reduces pain (MD -0.82) and improves muscle strength in patients with knee osteoarthritis
- Second-generation bicruciate-retaining TKA shows 5.7% revision rate in meta-analysis
- Tai Chi and Wuqinxi reduce pain while Pilates and Baduanjin improve physical function in knee osteoarthritis
- Exercise therapy significantly improves pain and physical function in elderly patients with knee osteoarthritis
- Probiotics show potential for knee osteoarthritis symptoms but evidence is limited
- Kinematic alignment improves function and pain over mechanical alignment in robotic TKA
- Patellar resurfacing and nonresurfacing show similar 5-year outcomes in total knee arthroplasty
- Systematic review and meta-analysis of Wuqinxi for knee osteoarthritis joint function
- Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response
- Feasibility Review of Portable Markerless Motion Capture for Knee OA
- Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
- Intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious adverse events
- Observational transcriptomic analysis identifies genes associated with knee osteoarthritis severity in older adults
- Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program
- Topical S. officinale preparations show efficacy for acute back pain, knee osteoarthritis, ankle sprains, and myalgia versus placebo
- 7-Year Observational Study Abstract Links BMI and Alignment to Cartilage Loss in Knee Osteoarthritis
- Meta-analysis finds 87% implant survivorship after 10 years in patients under 50 undergoing TKA
- Memantine reduces opioid use but not pain in knee osteoarthritis patients after surgery
- Medial Unicompartmental Knee Arthroplasty Shows Small Advantages Over Total Knee Arthroplasty in Severe Anteromedial Knee Osteoarthritis
- Platelet-rich plasma therapy in knee osteoarthritis patients showed high prediction accuracy for pain reduction
- CT-SMA improves trabecular estimation and OA diagnosis in knee osteoarthritis cohorts
- Meta-analysis finds noninvasive electrical stimulation improves pain and function in knee osteoarthritis
- Otago Exercise Program improves knee function and mobility after total knee arthroplasty in meta-analysis
- Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
- Deep learning reconstruction improves 5.0 Tesla knee MRI quality and diagnostic agreement in 69-patient cohort
- IPFP preservation versus resection in TKA shows no significant difference in 12-month KOOS scores
- Sarcopenic obesity prevalence is 28% in adults with advanced knee OA and severe obesity
- Pain catastrophizing predicts tDCS response patterns in knee osteoarthritis pain
- Mobilization with movement reduces pain and disability in knee osteoarthritis meta-analysis