N/A N=42 Randomized Other

Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios.

Cardiac Arrest

Bottom Line

View on ClinicalTrials.gov: NCT00380757 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2025

Primary outcome: Primary: CPR Quality — 128.5; 126.6 count of chest compressions

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: bystander CPR using 30:2 ratio vs 15:2 ratio (Procedure)
Age: Adult, Older Adult · 55+ yrs
Sex: All
Sponsor: Ottawa Hospital Research Institute
Primary completion: Jul 2006

Outcome Measures

Outcome	Result	p-value
PRIMARY CPR Quality	128.5; 126.6	—
SECONDARY Borg Rating of Perceived Exertion Blood Pressure Borg Rating of Perceived Exertion Scale	3.3; 3.5	—

Summary

STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 30:2 versus the old 15:2 chest compression to ventilation International Resuscitation Guidelines, in a population aged 55 or greater. More specifically, we will compare each CPR ratio with regard to: 1. The achieved frequency and depth of chest compressions, 2. Participant rating of their perceived level of exertion, and 3. Resulting serum lactate levels in a subset of the participants. STUDY HYPOTHESIS In a population aged 55 or greater, the new 30:2 CPR ratio will lead to: 1. less frequent and shallower chest compressions over the 5-minute study period; 2. higher rating of perceived level of exertion; and 3. higher serum lactate levels in a subset of participants when compared to the old 15:2 CPR ratio.

Eligibility Criteria

Inclusion Criteria

Male or female aged 55 or older
Must score 3 or less on the validated Clinical Frailty Scale 11
Able to follow instructions in English or French
Able to understand and give informed consent

Exclusion Criteria

Musculoskeletal condition precluding the ability to kneel down and perform CPR (e.g. severe arthritis, cast, wrist sprain, recent joint surgery)
Cardiovascular condition precluding the ability to perform a moderate effort e.g. myocardial infarction or cardiovascular procedure in the last 3 months, recurrent angina, chest pain under investigation)
Pulmonary condition precluding the ability to perform a moderate effort (e.g. emphysema, severe asthma, pneumonia)
Active communicable disease e.g. tuberculosis, meningitis, gastro enteritis, hepatitis A or B, herpes simplex)
Inability to perform chest compressions at appropriate rate and depth despite positive feedback during one to two-minute practice session

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Data sourced from ClinicalTrials.gov (NCT00380757). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.