N/A
Completed N=99
Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise
Source: ClinicalTrials.gov NCT00387712 ↗Enrolled (actual)
99
Serious AEs
3.0%
Results posted
Sep 2017
Primary outcomePrimary: Cardiovascular Fitness (VO2 Peak) — 15.9; 16.6; 21.3; 17.5 ml/kg/min — p=0.001
Summary
The purpose of this study is to first define whether abnormalities of skeletal muscle are related to the presence of inflammation and to poor motor performance and whether this can be modified by exercise interventions.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cardiovascular Fitness (VO2 Peak) |
15.9; 16.6; 21.3; 17.5 | 0.001 sig |
| PRIMARY Paretic Thigh Skeletal Muscle Myosin Heavy Chain Myosin Heavy Chain Isoform 2a |
3.35; 3.64; 4.40; 5.44 | 0.11 |
| SECONDARY 30 Foot Walk Time (Sec) |
15.4; 17.2; 13.8; 15.9 | 0.81 |
Eligibility Criteria
Inclusion Criteria
- Chronic stroke (>6 months after initial stroke)
- Age 40-80
- Stable neurologic deficits
- Able to walk with an assistive device
- Language skills to understand the training program safely
Exclusion Criteria
- No anticoagulation or medical conditions that preclude exercise.
- No dementias or depression
Data sourced from ClinicalTrials.gov (NCT00387712). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.