N/A N=99 Randomized Treatment

Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise

Stroke · Inflammation

Bottom Line

View on ClinicalTrials.gov: NCT00387712 ↗

Enrolled (actual)

Serious AEs

3.0%

Results posted

Sep 2017

Primary outcome: Primary: Cardiovascular Fitness (VO2 Peak) — 15.9; 16.6; 21.3; 17.5 ml/kg/min — p=0.001

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Velocity based treadmill training (Other); Duration based treadmill training (Other)
Age: Adult, Older Adult · 40+ yrs
Sex: All
Sponsor: VA Office of Research and Development
Primary completion: Aug 2012

Outcome Measures

Outcome	Result	p-value
PRIMARY Cardiovascular Fitness (VO2 Peak)	15.9; 16.6; 21.3; 17.5	0.001 sig
PRIMARY Paretic Thigh Skeletal Muscle Myosin Heavy Chain Myosin Heavy Chain Isoform 2a	3.35; 3.64; 4.40; 5.44	0.11
SECONDARY 30 Foot Walk Time (Sec)	15.4; 17.2; 13.8; 15.9	0.81

Summary

The purpose of this study is to first define whether abnormalities of skeletal muscle are related to the presence of inflammation and to poor motor performance and whether this can be modified by exercise interventions.

Eligibility Criteria

Inclusion Criteria

Chronic stroke (>6 months after initial stroke)
Age 40-80
Stable neurologic deficits
Able to walk with an assistive device
Language skills to understand the training program safely

Exclusion Criteria

No anticoagulation or medical conditions that preclude exercise.
No dementias or depression

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00387712). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.