N/A
N=290
REVEAL III: Risk Evaluation and Education for Alzheimer's Disease
Alzheimer Disease
Bottom Line
View on ClinicalTrials.gov: NCT00462917 ↗Enrolled (actual)
290
Serious AEs
0.4%
Results posted
Sep 2014
Primary outcome: Primary: Center for Epidemiological Studies-Depression Scale (CES-D) — 4.8; 7.0; 6.4; 5.5 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Pleiotropic info, in-person disclosure (Behavioral); AD-only info, in-person disclosure (Behavioral); Pleiotropic info, phone disclosure (Behavioral); AD-only info, phone disclosure (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Brigham and Women's Hospital
- Primary completion
- Oct 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Center for Epidemiological Studies-Depression Scale (CES-D) |
4.8; 7.0; 6.4; 5.5; 5.5; 6.6 | — |
| PRIMARY Beck Anxiety Inventory (BAI) |
2.9; 4.1; 3.2; 3.1; 3.4; 3.4 | — |
| SECONDARY Impact of Events Scale (IES) |
3.4; 4.5; 3.7; 3.8; 3.5; 4.0 | — |
Summary
The purpose of this study is to provide healthy adults with genetic testing and information about their chances of developing Alzheimer's disease.
Eligibility Criteria
Inclusion Criteria
- Aged 18 years to 85 years old
Exclusion Criteria
- Unable to visit a study site
- Current untreated depression or anxiety
- Family history of AD diagnosed under age 60
- More than one first-degree relative diagnosed with AD (e.g. Mother and brother)
Data sourced from ClinicalTrials.gov (NCT00462917). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.