Systematic review and meta-analysis of dietary restriction in Alzheimer's mouse models
Dietary restrictions show mixed results in Alzheimer's mouse models
This systematic review and meta-analysis of 23 studies examined five dietary restriction regimens in Alzheimer's disease mouse models. Calor…
A meta-analysis of 23 studies found fasting-mimicking diets had the largest effects, while intermittent fasting improved memory but worsened…
Framingham cohort links longitudinal brain atrophy patterns to cognitive decline and AD biomarkers in community-based participants
Brain shrinkage patterns predict Alzheimer's risk in older adults
This community-based cohort study of 300 participants from the Framingham Heart Study analyzed longitudinal brain atrophy patterns using MRI…
A study of 300 older adults found specific brain shrinkage patterns that strongly predict Alzheimer's disease and worse thinking skills.
Personalized Feature Statistics framework characterizes genetic variant effects in Alzheimer's Disease across diverse ancestries
Genetic risk for Alzheimer's varies by ancestry in new analysis
This cohort study analyzed ancestrally diverse cohorts in the Alzheimer's Disease Sequencing Project (ADSP). The Personalized Feature Statis…
A new analysis shows genetic risk for Alzheimer's disease changes across different ancestry backgrounds, offering a clearer view of individu…
Pilot study assesses safety and feasibility of young donor plasma replacement in mild cognitive impairment
Twelve patients with early memory loss received young donor blood plasma safely.
This pilot study examined the safety and feasibility of replacing patient plasma with that from young donors in twelve individuals with mild…
Twelve patients with early memory loss received young donor blood plasma safely. The procedure was feasible and well tolerated.
MMSE-CDR-SB residual deviation from AD pattern linked to non-AD pathologies in autopsy and clinical cohorts
A simple score spots brain changes that are not typical Alzheimer's disease
This cohort study used an MMSE-CDR-SB residual to measure deviation from an AD-typical cognitive-functional pattern in an autopsy cohort (n=…
A new score helps doctors spot brain changes that look different from standard Alzheimer's disease, offering a clearer path to understanding…
Computational model shows individualized gamma stimulation outperforms fixed frequency in Alzheimer's simulation
Computational model suggests personalized stimulation beats fixed frequency for Alzheimer's
This computational model study simulated 200 individuals with Alzheimer's disease to compare individualized gamma frequency stimulation vers…
A simulated study indicates individualized frequency stimulation offers a four-fold advantage over fixed 40 Hz stimulation for Alzheimer's d…
Review of cross-sectional EEG study on 32-Hz stimulation in Alzheimer's disease and mild cognitive impairment
Why Some Brains Respond Better to Gamma Stimulation in Alzheimer's
This review summarizes a cross-sectional EEG study evaluating 32-Hz visual stimulation in adults aged 55 years or older with Alzheimer's dis…
People with lower cognitive reserve showed bigger brain network changes during gamma stimulation, suggesting who might benefit most.
Systematic review of PPAV11 proteomic signature shows high accuracy for Alzheimer's disease diagnosis and prognosis
New Alzheimer’s Test Shows Early Brain Changes
This systematic review evaluates the diagnostic accuracy and prognostic capacity of PPAV11, a signature of eleven consistently dysregulated …
Scientists have found a set of 11 proteins in spinal fluid that reliably signal early Alzheimer’s, even before severe symptoms appear, offer…
Computational neuroimaging study finds tDCS anxiety reduction linked to specific fMRI connectivity patterns in older adults
New scan predicts who will get relief from anxiety treatment
This primary study abstract examines transcranial direct-current stimulation (tDCS) effects on anxiety in older adults at risk for Alzheimer…
A new brain scan can predict exactly which older adults with memory issues will feel less anxiety after a specific treatment, helping doctor…
Early-onset epilepsy associated with higher biomarker abnormality in older adults
Older Adults With Epilepsy Face Higher Dementia Risk, New Brain Tests Reveal
This observational study of 84 older adults with focal epilepsy examined AT(N) biomarker profiles and cognitive associations. The analysis f…
New brain blood tests show most older adults with epilepsy have signs of dementia risk, even without symptoms.
Systematic review and meta-analysis of Kai-xin-san in animal models of Alzheimer's disease
Herbal formula shows promise against Alzheimer's in animal study
This systematic review and meta-analysis evaluated Kai-xin-san (KXS) in 2,681 animals across various Alzheimer's disease models. The synthes…
A traditional Chinese herbal mix improved memory and reduced Alzheimer's markers in 2,681 animals, but study quality issues mean results may…
Sex hormone traits linked to Alzheimer's risk in sex-specific Mendelian randomization study
Women and men face different Alzheimer's risks linked to specific hormones.
A cohort study using Mendelian randomization found that bioavailable testosterone in women and SHBG in men are associated with lower Alzheim…
New science shows specific hormones protect women and men from Alzheimer's disease in unique ways that doctors must consider.