Phase 3
N=11
Impact of Switching to Continuous Release Dopamine Agonists
Parkinson Disease
Bottom Line
View on ClinicalTrials.gov: NCT00465452 ↗Enrolled (actual)
11
Serious AEs
0.0%
Results posted
May 2025
Primary outcome: Primary: Unified Parkinson's Disease Rating Scale (UPDRS), Parts 3 (Motor Performance) and 4 (Disability). — 19.2; 17.6; 5.1; 2.9 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- Continuous Release Dopamine Agonists (Drug)
- Age
- Adult, Older Adult · 55+ yrs
- Sex
- All
- Sponsor
- University of Toledo
- Primary completion
- Mar 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Unified Parkinson's Disease Rating Scale (UPDRS), Parts 3 (Motor Performance) and 4 (Disability). |
19.2; 17.6; 5.1; 2.9 | — |
| PRIMARY Mini-Mental Status Exam (MMSE), the Clock Drawing Test (CDT), the Patient Health Questionnaire (PHQ-9). |
28.9; 29.1; 9.8; 9.4; 7.5; 6.2 | — |
| PRIMARY Peripheral Edema, as Measured by Quantitative Assessment of Ankle Edema |
225.11; 224.38 | — |
| PRIMARY Patient Satisfaction Questionnaire |
0.7; 5.2 | — |
| PRIMARY Parkinson's Disease Questionnaire (PDQ-39) |
32.3; 31.1 | — |
Summary
The purpose of this proposal is to determine if switching PD patients treated with pramipexole to ropinirole CR reduces the non-motor side effects frequently experienced by these patients. Side effects that we will monitor in particular include somnolence, peripheral edema, cognitive decline with and without hallucinations. PD patients followed in the MUO Neurology Clinic who are being treated with pramipexole and have evidence of at least one of the following symptoms: somnolence, cognitive impairment with or without hallucinations, or peripheral edema will be offered the opportunity to participate in this study.
Eligibility Criteria
Inclusion Criteria
Each subject must meet all of the following inclusion criteria to qualify for entrance into the study:
- Subjects who are male or female and are aged 55 and older.
- Subjects and/or their legal guardians must be able and willing to give informed consent.
- Subjects must be on stable doses of pramipexole for greater than 4 weeks duration prior to screening.
- Subjects who are female must be non-pregnant and non-nursing. Women of Child-Bearing Potential (WOCBP) must use a reliable method of contraception (e.g., oral contraceptive or long-term injectable or implantable hormonal contraceptive, double-barrier methods, such as condom and diaphragm, condom and foam, condom and sponge or intra-uterine devices) and have a negative serum pregnancy test at screening. Women are considered to not be of child-bearing potential if they have been surgically sterilized (physician-documented hysterectomy or tubal ligation) or if they are post-menopausal.
- Subjects must have a clinical diagnosis of Parkinson's based on the presence of at least 2 of the 3 cardinal criteria - rest tremor, bradykinesia, rigidity - and no obvious history of head trauma, stroke, infectious, structural, or metabolic abnormality consistent with an alternative diagnosis to Parkinson's disease.
- Evidence of one or more of the following symptoms: somnolence (ESS score ≥ 9), cognitive decline (MMSE 30mm drop in systolic pressure and/or >20mm drop in diastolic pressure) associated with syncope.
- Subjects started within the last 14 days on any drug known to substantially inhibit CYP1A2 (e.g., cimetidine, fluvoxamine) or induce CYP1A2 (e.g.omeprazole) (Note: Subjects already on these agents may be enrolled but must remain on the stable doses of the agents from 14 days prior to the beginning of the study).
- Subjects who have other medical conditions that are considered clinically unstable or that may compromise the safety of the patient during this study.
Data sourced from ClinicalTrials.gov (NCT00465452). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.