Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Exercise, microbiota, and tRNA modifications may influence mitochondrial function and proteostasis in Parkinson's disease
Exercise and gut health may protect brain cells in Parkinson's
This narrative review explores the exercise-microbiota-queuine-tRNA axis as a potential mechanism for dopaminergic neuroprotection in Parkin…
New research explores how exercise, gut bacteria, and RNA modifications might work together to protect the brain from Parkinson's disease.
Current non-motor symptom classifications fail Parkinson's complexity, review finds
Parkinson's symptom classification fails patients, review finds
This narrative review critiques current symptom-based classification systems for non-motor symptoms (NMS) in Parkinson's disease, finding th…
Current systems for grouping Parkinson's non-motor symptoms miss their complexity, a new review reveals.
Bipolar disorder is associated with a 3.65-fold higher risk of Parkinson's disease in six cohort studies
People with bipolar disorder face higher risk of developing Parkinson's disease based on recent analysis
This meta-analysis of six cohort studies evaluated the incidence of Parkinson's disease in individuals with bipolar disorder. The pooled ana…
A review of six studies found people with bipolar disorder have a much higher chance of getting Parkinson's disease. However, experts say we…
HMC3 microglial model illuminates neurodegenerative mechanisms and early therapeutic discovery
New tool helps scientists study brain cell stress in Alzheimer's and Parkinson's disease
This narrative review synthesizes experimental evidence from HMC3 human microglial cell line and co-culture systems to explore mechanisms in…
Scientists use a special human brain cell line to study stress and cell death in diseases like Alzheimer's and Parkinson's, offering a new w…
Six novel loci and nine recessive loci identified for young onset Parkinson's disease in European ancestry
Genetic clues to young onset Parkinson's disease found in large global study
This meta-analysis of genome-wide association studies in 1,528 patients and 20,408 controls identified six independent loci and nine recessi…
A massive analysis of genetic data found six new spots in our DNA linked to early Parkinson's disease, offering hope for better prevention a…
Nutrient and metabolite interventions for neurodegenerative diseases show inconsistent clinical translation
Dietary nutrients show mixed results for brain diseases in lab and early human data
This narrative review synthesizes evidence on nutrients and metabolites for Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic la…
Nutrients like vitamins and marine compounds show promise in labs, but human evidence for brain diseases remains inconsistent and unclear.
QSM MRI reveals distinct iron deposition patterns differentiating Parkinsonian syndromes
Brain MRI technique may help tell apart Parkinson's and similar disorders
This systematic review and meta-analysis of 626 PD, 160 MSA, 176 PSP patients and 256 controls found that quantitative susceptibility mappin…
A special MRI can spot distinct brain iron patterns in Parkinson's and related diseases, offering a potential diagnostic tool.
Continuous subcutaneous foslevodopa/foscarbidopa improves off time in Parkinson's disease; severe adverse events higher in prior DBS group
Patients with Parkinsons disease who had prior brain surgery saw more side effects while using new skin patches
This post hoc analysis of an open-label phase 3 trial evaluated continuous subcutaneous infusion of foslevodopa/foscarbidopa in 244 patients…
A new look at trial data shows skin patches help Parkinsons patients move better and sleep longer. However, those who had brain surgery earl…
GBA1 L444P carriers have ninefold higher odds of Parkinson's disease than non-carriers
People with one GBA1 L444P gene change face much higher risk of developing Parkinson's disease compared to those without it
This systematic review and meta-analysis of 33,752 PD patients and 34,101 controls found that heterozygous GBA1 L444P carriers had markedly …
A large review of over sixty-seven thousand people found that carrying one copy of the GBA1 L444P gene change greatly increases the chance o…
Prasinezumab showed non-significant delay in motor progression versus placebo in early-stage Parkinson's disease
Early Parkinson's drug trial shows no delay in motor progression
This phase 2b trial evaluated intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable medication. The study f…
A Phase 2b trial of prasinezumab in early Parkinson's disease failed to meet its primary endpoint of delaying motor progression compared to …
Narrative review suggests music therapy may improve cognition and neuropsychiatric symptoms in cognitive impairment
Music therapy may help minds affected by Alzheimer's and other cognitive conditions
This narrative review examines the role of music therapy for cognitive impairment. The authors suggest that music therapy may improve cognit…
Music therapy might improve thinking and mood for people with Alzheimer's disease, mild cognitive impairment, or Parkinson's-related cogniti…
Questions about Parkinson's Disease
How does the P-BANN framework help analyze proteomics data for Parkinson disease research?
The P-BANN framework uses a biologically annotated neural network with Bayesian variable selection to identify key proteins and pathways from proteomics data, aiding Parkinson disease research.
Full answer →How does my perception of my illness affect my quality of life with Parkinson disease?
Your perception of Parkinson's — how you view its impact and control — can significantly affect your quality of life, sometimes more than the severity of motor symptoms alone.
Full answer →Can a soft robotic exoskeleton help improve my walking speed and stride length?
Yes, a soft robotic exoskeleton can improve walking speed and stride length in people with Parkinson disease, based on recent studies showing significant gains after 4 weeks of training.
Full answer →Is there a link between ferroptosis and Parkinson's disease immune responses?
Yes, ferroptosis and immune responses are linked in Parkinson's disease through a bidirectional cycle where neuroinflammation promotes iron-dependent cell death, which in turn amplifies immune activation.
Full answer →Do patients with Parkinson's disease and mild cognitive impairment have different brain volumes?
Yes, patients with Parkinson's disease and mild cognitive impairment have smaller brain volumes in several subcortical regions, including the hippocampus, thalamus, putamen, and amygdala, compared to those with normal cognition.
Full answer →Does deep brain stimulation help reduce freezing of gait in Parkinson's disease?
Yes, deep brain stimulation can reduce freezing of gait in Parkinson's disease, especially when used without medication, but individual responses vary.
Full answer →Can acupuncture help improve sleep quality for people with Parkinson's disease?
Yes, acupuncture can improve sleep quality in Parkinson's disease, with systematic reviews and trials showing significant benefits on sleep scales, though more high-quality research is needed.
Full answer →All Parkinson's Disease Articles
- Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
- Exercise, microbiota, and tRNA modifications may influence mitochondrial function and proteostasis in Parkinson's disease
- Current non-motor symptom classifications fail Parkinson's complexity, review finds
- Bipolar disorder is associated with a 3.65-fold higher risk of Parkinson's disease in six cohort studies
- Six novel loci and nine recessive loci identified for young onset Parkinson's disease in European ancestry
- HMC3 microglial model illuminates neurodegenerative mechanisms and early therapeutic discovery
- Nutrient and metabolite interventions for neurodegenerative diseases show inconsistent clinical translation
- QSM MRI reveals distinct iron deposition patterns differentiating Parkinsonian syndromes
- Continuous subcutaneous foslevodopa/foscarbidopa improves off time in Parkinson's disease; severe adverse events higher in prior DBS group
- GBA1 L444P carriers have ninefold higher odds of Parkinson's disease than non-carriers
- Prasinezumab showed non-significant delay in motor progression versus placebo in early-stage Parkinson's disease
- Narrative review suggests music therapy may improve cognition and neuropsychiatric symptoms in cognitive impairment
- Combined motor and cognitive therapy shows mixed benefits in Parkinson's disease
- Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
- Systematic review finds VR and physiotherapy equally effective for Parkinson's balance
- Sensory cueing improves gait in Parkinson's disease patients
- Deep brain stimulation improves motor function and reduces levodopa needs in Parkinson's disease patients regardless of GBA mutation status
- Meta-analysis links mitochondrial polygenic score to alpha-synuclein seeding in LRRK2-related Parkinson's disease
- Narrative review examines RNA editing alterations in Parkinson's disease patients
- Systematic review of AI applications for protein misfolding diseases
- Systematic review on nocebo effect induction in chronic conditions and clinical communication
- Meta-analysis of GLP-1 agonists for Parkinson's disease motor symptoms shows limited benefit
- Systematic review of DBS for freezing of gait in Parkinson's disease
- Systematic review and meta-analysis synthesizes acupuncture effects on sleep in Parkinson's disease
- FDA Approves Nuplazid (pimavanserin) for Parkinson's Disease Psychosis
- FDA Approves Nuplazid (pimavanserin) for Parkinson's Disease Psychosis
- Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
- Meta-analysis shows MRI volumetric differences in Parkinson's disease with mild cognitive impairment versus cognitively normal patients
- Review of P-BANN framework for Parkinson disease proteomics data analysis
- Review of LLM-generated synthetic Parkinson's patients for in silico trials
- Soft robotic exoskeleton training improved gait speed and stride length in people with Parkinson disease over four weeks
- Cross-sectional review links illness perceptions to quality of life variance in Parkinson disease patients
- Narrative review highlights association between abnormal bilirubin and Parkinson's disease motor outcomes
- Psychomotor retardation in depression linked to increased Parkinson's risk
- Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
- Auditory targeted memory reactivation during NREM sleep nap shows no effect on motor retention
- Cohort study compares homocysteine and uric acid levels in Parkinson's disease-related and post-stroke cognitive impairment
- CSF SAA status associates with levodopa responsiveness and motor progression in Parkinson's disease patients
- Baduanjin training improves motor symptoms and anxiety more than brisk walking in Parkinson's disease
- Narrative review examines resveratrol in Alzheimer's, Parkinson's, MS, and cerebral ischemia with noted limitations
- Review of music therapy for motor, speech, and cognitive impairments in stroke, Parkinson's, and cerebral palsy
- FDA Approves DATSCAN (ioflupane I-123) for Striatal Dopamine Transporter Visualization in Suspected Parkinsonian Syndromes or Dementia with Lewy Bodies
- Observational review of phenoconversion rates and biomarker alignment in Parkinson's disease genetic cohorts
- Systematic review and meta-analysis of oxidative stress biomarkers in older adults with T2DM or Parkinson's disease
- Genomic and proteomic investigation suggests genetic liability to smoking initiation may protect against Parkinson disease
- Prospective open-label study links brain MRI to impulse control changes after DBS for Parkinson's
- Pilot Abstract Reports Artificial Baroreflex System With DBS in Parkinson Disease Patients
- Intermittent theta-burst stimulation of right putamen improves motor scores in Parkinson's disease patients
- Meta-analysis links speech features to severity in Parkinsons, cerebral palsy, and ALS
- Review of flavonoids shows preclinical neuroprotective potential in Parkinson's disease models
- Protocol for cane training trial in Parkinson's disease to assess gait speed and confidence
- Hypothesis links cumulative levodopa exposure to frailty and reduced healthspan in Parkinson's disease
- Blood miR-7-5p levels decrease more rapidly in Parkinson's disease patients than in healthy controls
- Qihuang needle therapy protocol for Parkinson's disease in 69 patients
- Review explores PARP-1 and α-synuclein interactions in Parkinson's disease neuropathology
- REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data
- Rhythmic auditory cueing and tDCS improve gait parameters in Parkinson's disease
- Sex-stratified multi-omic integration identifies specific molecular candidates and pathways in Parkinsons disease
- Parkinson disease associated with higher cerebral small vessel disease burden compared to healthy controls in this meta-analysis
- Meta-analysis finds DBS improves REM sleep and reduces wakefulness in Parkinson's disease
- Systematic review hypothesizes vitamin D3 and A combination may mitigate neurodegeneration
- Peri-lead edema observed in 9.9% of Parkinson's patients undergoing deep brain stimulation surgery
- China's rehabilitation needs for neurological disorders increased significantly from 1990 to 2021
- Connectomics-guided meta-learning framework decoded sleep spindles in 17 Parkinson's disease patients with DBS implants
- 6-metabolite blood biomarkers aid differential diagnosis of Parkinson's disease versus healthy controls and other neurodegenerative conditions
- In Parkinson's disease, OFF predictability and clinical features explain more OFF impact variance than OFF time
- Luteolin shows neuroprotective potential in preclinical models for Alzheimer's, Parkinson's, Huntington's, and multiple sclerosis
- FDG-PET reveals dysregulated glucose metabolism as a common feature across late-onset neurodegenerative diseases with unique patterns
- Rare variants in 44 dystonia genes show no major contribution to Parkinson's disease risk overall
- CSF alpha-synuclein seed amplification assay shows high intra-individual consistency in Parkinson's disease
- Immersive virtual reality rehabilitation improved dynamic balance, motor function, and quality of life in Parkinson's disease patients
- IMB model-based education improved medication adherence and self-management in Parkinson's disease patients at six months versus routine care
- Systematic review finds wide variation in neurodegenerative disease prevalence among older Russian adults
- Systematic review examines neuroprotective plant extracts for Parkinson's disease mechanisms
- Greater cognitive variability in NSD Stage 2 predicts progression to advanced stages in observational study
- Modeling suggests 30% Parkinson's progression reduction may lower 10-year milestone risks
- MRgFUS thalamotomy lesion connectivity patterns linked to tremor control in Parkinson's disease
- DBSgram framework demonstrates feasibility for biomarker-guided DBS programming in Parkinson's disease
- Retrospective study finds 12.1% of PD/ET patients underwent DBS surgery at a tertiary center
- Review suggests acupuncture may target cell death pathways in Parkinson's disease
- Meta-analysis finds depression associated with elevated Parkinson's disease risk
- Parkinson disease death rates increased in US adults 65+ from 1999 to 2017
- Telehealth CBT improves quality of life in veterans with Parkinson's disease and comorbid depression
- Color therapy shows reduced fatigue and depression, improved quality of life in Parkinson's patients
- Cycling exercise may reduce urinary symptom progression in early Parkinson's disease pilot trial
- Review organizes pharmacological strategies targeting gut-brain axis for neurological and psychiatric disorders
- GLP-1RAs Show No Significant Motor Benefit in Parkinson's Disease Meta-Analysis
- Fatal serotonin syndrome in Parkinson's patient on rasagiline after sequential SSRI administration