Phase 3
Completed N=183
Superficial, Cervical Block in Thyroid Surgery, a Randomized Controlled Trial
Source: ClinicalTrials.gov NCT00472446 ↗Enrolled (actual)
183
Serious AEs
0.6%
Results posted
Sep 2016
Primary outcomePrimary: Post-operative Pain Measured by Visual Analogue Scale — 2.15; 2.02; 2.84; 2.72 units on a scale — p=.028
◆ Published Evidence
Established
44citations · ~3 / year
Randomized controlled trial of bilateral superficial cervical plexus block versus placebo in thyroid surgery.
Summary
The study investigates the impact on post-operative pain of the superficial cervical block with bupivacaine combined with subcutaneous infiltration of the incisional area in thyroid surgery under general anesthesia. In addition, cost savings using the cervical block are evaluated (due to reduced length of hospital stay).
The study is prospective, randomized, double blind, and placebo-controlled. The study is performed at the Department of Surgery, Cantonal Hospital of St. Gallen.
Linked Publications
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Randomized controlled trial of bilateral superficial cervical plexus block versus placebo in thyroid surgery.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Post-operative Pain Measured by Visual Analogue Scale |
1.95; 1.51; 2.20; 2.06 | — |
| PRIMARY Pooled Relative Treatment Effect of VAS |
0.47; 0.45; 0.55; 0.54 | 0.016 sig |
| SECONDARY Post-operative Pain Measured by Visual Analogue Scale |
1.95; 1.51; 2.20; 2.06 | — |
| SECONDARY Consumption of Post-operative Analgetics |
21; 23; 18; 24; 6; 7 | 0.94 |
| SECONDARY Mean Consumption of Post-operative Analgetics |
3.33; 3.37; 4.06; 4.33; 1.25; .93 | 0.328 |
| SECONDARY Hospital Stay |
1.8; 1.6; 2.0; 1.6 | 0.925 |
Eligibility Criteria
Inclusion Criteria
- Elective thyroid or combined thyroid/parathyroid surgery, restricted to the central cervical compartment
- Informed consent
Exclusion Criteria
- Intolerance to used medication
- Recurrent disease
- Neck dissection, sternotomy
- Emergency surgery
Data sourced from ClinicalTrials.gov (NCT00472446) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.