Early Phase 1
N=6
Pilot Study of Lucentis Combined With Proton Beam Irradiation in Treating Wet Age-related Macular Degeneration
Age-related Macular Degeneration
Bottom Line
View on ClinicalTrials.gov: NCT00517010 ↗Enrolled (actual)
6
Serious AEs
0.0%
Results posted
Jul 2016
Primary outcome: Primary: Incidence and Severity of Ocular Adverse Events — 0 number of adverse events
Study Design & Population
- Study type
- Interventional
- Phase
- Early Phase 1
- Interventions
- Proton beam irradiation and ranibizumab (Drug)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- University of California, Davis
- Primary completion
- Jun 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Incidence and Severity of Ocular Adverse Events |
— | — |
| SECONDARY 1. Change in BCVA From Baseline |
2.8 | — |
Summary
Because a possible synergism of radiation and inhibitors of vascular endothelial growth factor has been shown in cancer patients and patients with wet macular degeneration, this pilot study is being conducted to determine whether treating wet macular degeneration with a combination of Lucentis and proton beam irradiation is safe. Lucentis is an inhibitor of vascular endothelial growth factor which was recently FDA approved for treatment of wet macular degeneration. It appears to be the most effective therapy thus far for wet macular degeneration among all drugs FDA approved for this condition. If no major safety issues are associated with this combination therapy, a larger study will be conducted to determine whether this combination therapy is more effective than Lucentis monotherapy.
Eligibility Criteria
Inclusion Criteria
- Ability to provide written informed consent and comply with study assessments for the full duration of the study
- Age > 50 years
- Patient related considerations
- Able to maintain follow-up for at least 24 months.
- Women must be postmenopausal without a period for at least one year.
- Hgb A1C < 6
- Diagnosed with Age-related Macular Degeneration (ARMD) with active subfoveal choroidal neovascular membrane (CNVM), new or recurrent
- Visual acuity 20/60 to 20/400
- Lesion size < 12 Disc Area
- Submacular hemorrhage less than 75% of total lesion
- Submacular fibrosis less than 25% of total lesion
- Candidate for intravitreal Lucentis
Exclusion Criteria
- Prior enrollment in the study
- Pregnancy (positive pregnancy test) or lactation
- Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated
- Participation in another simultaneous medical investigation or trial
- CNVM within 1 mm from the disc margin
- Photodynamic Therapy (PDT) within 3 months
- Anti-VEGF therapy within 6 weeks
- Intravitreal or subtenon's Kenalog within 6 months
- Intraocular surgery within 3 months or expected in the next 6 months
- Current or planned participation in other experimental treatments for wet AMD
- Other concurrent retinopathy or optic neuropathy
- Other causes of CNVM, i.e. myopic degeneration or ocular histoplasmosis (POHS)
- Significant media opacity precluding adequate view of the fundus for exam,
- photography or OCT
- History of radiation therapy to the head or study eye
- Systemic anticoagulation with coumadin
- Head tremor or h/o claustrophobia precluding positioning for proton irradiation
- Inability to maintain steady fixation with either eye
- Diabetes mellitus requiring treatment
- History of Malignancy treated within 5 years
- Allergy to Fluorescein dye
Data sourced from ClinicalTrials.gov (NCT00517010). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.