Trial of Dasatinib (Sprycel®) in Subjects With Hormone-refractory Prostate Cancer

Inclusion Criteria

• Must have biopsy-proven adenocarcinoma of the prostate
• Must have hormone-refractory prostate cancer, defined as an increasing PSA by >= 3 ng/ml from androgen-blockade nadir, or new measurable or evaluable lesion on imaging studies, after treatment with orchiectomy, luteinizing hormone-releasing hormone (LHRH) agonist, antiandrogen or diethylstilbestrol (DES)
• Subjects must have received at least one cycle of single-agent or combination chemotherapy for hormone refractory prostate cancer (HRPC), last administered at least 4 weeks prior to the start of dasatinib
• Subjects may not have received more than one type (single agent or combination) of chemotherapy regimen; subjects may include (but are not limited to) the following: HRPC subjects who were treated with palliative chemotherapy and either failed to respond, or responded for a period of time but now have worsening disease (i.e. relapsed/refractory to chemotherapy); HRPC subjects who were treated with palliative chemotherapy but stopped treatment because of toxicity (i.e. intolerant of chemotherapy); HRPC subjects who have been treated with palliative chemotherapy with response, whose chemotherapy has been interrupted, and who now have evidence of progressive disease (i.e. potentially chemotherapy responsive but subject does not desire to restart cytotoxic drugs)
• Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
• Life expectancy of at least 8 weeks, based on clinical judgment of the treating physician
• Adequate hematologic, renal and liver function as evidenced by the following (subjects may have lower hematologic parameters if the cytopenias are thought by the treating physician to be secondary to marrow involvement by prostate cancer):
• white blood cell count (WBC) > 2.0 bil/L; grade 0-1
• absolute neutrophil count (ANC) > 1.0 bil/L; grade 0-1
• Platelets > 100 bil/L; grade 0-1
• Hemoglobin > 8.0gm/dL
• Creatinine = lower limit of normal
• Elevated PSA level (at least 3 ng/mL), or measurable prostate cancer by CT or MRI scans (PSA level must have shown two consecutive increases [at >= 14 day intervals] since the previous nadir)
• Ability to take oral medication (dasatinib must be swallowed whole)
• Subjects of reproductive potential must agree to use an adequate method of contraception throughout treatment and for at least 4 weeks after study drug is stopped
• Signed informed consent documents including Health Insurance Portability and Accountability Act (HIPAA) according to institutional guidelines
• Concomitant Medications: Patient agrees to discontinue St. Johns Wort while receiving dasatinib therapy (in addition Patient agrees that IV bisphosphonates will be withheld for the first 8 weeks of dasatinib therapy due to risk of hypocalcemia)

Exclusion Criteria

• Subjects should have had no chemotherapy within 4 weeks of the start of treatment with dasatinib
• Prior localized radiotherapy for metastatic disease is permitted, provided the treatment volume is less than25% of potential marrow space (the radiotherapy must have been completed 6 weeks prior to enrollment)
• Systemic radiotherapy with samarium-153 must have been completed at least 2 months prior to enrollment (subjects may not have received prior strontium-89 [Metastron] therapy)
• At least 6 weeks have elapsed from the last dose of cytotoxic or targeted therapeutics to the time of prescreening; if the subject has received a combination regimen of standard chemotherapy plus an investigational agent, a 6 week washout period is required
• Subjects may not have received treatment with any kinase inhibitor
• At least 2 months must have elapsed from time of dosing with vaccines to the time of prescreening
• No malignancy, other than prostate cancer, that required radiotherapy or systemic treatment within the past 5 years
• Subjects may not have any of the following: Clinical evidence of uncontrolled heart failure, myocardial infarction, or angina within the p