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Prostate Cancer

57 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Prostate Cancer

669 trials tracked for Prostate Cancer: 125 in phase 3 or 4 and 47 with published results. The most-cited published study has 1665 citations.

669Trials tracked
125Phase 3 & 4
0Recruiting
47With published results
Phase distribution
Phase 4 15 Phase 3 110 Phase 2 350 Phase 1 43 Other / NA 151
  1. Phase 3 Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases Completed · 1,665 cited
  2. Phase 3 Gallium-68 PSMA-11 Positron Emission Tomography (PET) Imaging in Patients With Biochemical Recurrence Completed · 793 cited
  3. Phase 3 Radiation Therapy With or Without Antiandrogen Therapy in Treating Patients With Stage I or Stage II Prostate Cancer Completed · 702 cited
  4. Phase 3 Radiation Therapy With or Without Bicalutamide for Recurrent pT3N0 Prostate Cancer After Radical Prostatectomy Completed · 665 cited
  5. Phase 3 Radiation Therapy in Treating Patients With Stage II Prostate Cancer Completed · 630 cited
  6. Phase 3 SWOG-9346, Hormone Therapy in Treating Men With Stage IV Prostate Cancer Completed · 573 cited
Show 44 more trials
  1. Phase 3 A Study to Evaluate the Safety and Efficacy of Relugolix in Men With Advanced Prostate Cancer Completed · 439 cited
  2. Phase 3 Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms Completed · 402 cited
  3. Phase 3 Cabazitaxel Versus Docetaxel Both With Prednisone in Patients With Metastatic Castration Resistant Prostate Cancer Completed · 356 cited
  4. Phase 3 Gallium-68 PSMA-11 PET in Intermediate to High-risk Preprostatectomy Patients Completed · 341 cited
  5. Phase 3 S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy Completed · 334 cited
  6. Phase 3 Cabazitaxel at 20 mg/m² Compared to 25 mg/m² With Prednisone for the Treatment of Metastatic Castration Resistant Prostate Cancer Completed · 291 cited
  7. Phase 3 Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100 Completed · 248 cited
  8. Phase 3 Study Comparing Orteronel Plus Prednisone in Participants With Metastatic Castration-Resistant Prostate Cancer. Completed · 232 cited
  9. Phase 3 Study Comparing Orteronel Plus Prednisone in Participants With Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer Completed · 231 cited
  10. Phase 3 FACBC Outcomes for Post Prostatectomy Completed · 187 cited
  11. Phase 4 Safety Study of Continued Enzalutamide Treatment In Prostate Cancer Patients Completed · 171 cited
  12. Phase 3 Darolutamide in Addition to ADT Versus ADT in Metastatic Hormone-sensitive Prostate Cancer Completed · 146 cited
  13. Phase 3 Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer Completed · 139 cited
  14. Phase 3 Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-7339-010/KEYLYNK-010) Completed · 136 cited
  15. Phase 3 Phase 3 Study of Immunotherapy to Treat Advanced Prostate Cancer Completed · 134 cited
  16. Phase 3 Radiation Therapy in Treating Patients With Stage II Prostate Cancer Completed · 126 cited
  17. Phase 3 S9921, Hormone Therapy With or Without Mitoxantrone and Prednisone in Patients Who Have Undergone Radical Prostatectomy for Prostate Cancer Completed · 112 cited
  18. Phase 3 Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer Completed · 110 cited
  19. Phase 3 Imaging Study to Investigate the Safety and Diagnostic Performance of rhPSMA 7.3 (18F) in Newly Diagnosed Prostate Cancer. Completed · 92 cited
  20. Phase 3 Diet in Altering Disease Progression in Patients With Prostate Cancer on Active Surveillance Completed · 66 cited
  21. Phase 3 Tadalafil in Preventing Erectile Dysfunction in Patients With Prostate Cancer Treated With Radiation Therapy Completed · 62 cited
  22. Phase 3 Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921) Completed · 49 cited
  23. Phase 3 Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer Completed · 42 cited
  24. Phase 3 Interstitial Brachytherapy With or Without External-Beam Radiation Therapy in Treating Patients With Prostate Cancer Completed · 39 cited
  25. Phase 3 S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer Completed · 38 cited
  26. Phase 3 18F Fluciclovine (FACBC) PET/CT in Patients With Rising PSA After Initial Prostate Cancer Treatment Completed · 31 cited
  27. Phase 3 A Study of Abiraterone Acetate Plus Low-Dose Prednisone Plus Androgen Deprivation Therapy (ADT) Versus ADT Alone in Newly Diagnosed Participants With High-Risk, Metastatic Hormone-Naive Prostate Cancer (mHNPC) Completed · 29 cited
  28. Phase 3 Chemotherapy After Prostatectomy (CAP) For High Risk Prostate Carcinoma Completed · 29 cited
  29. Phase 3 A Study of Degarelix in Patients With Prostate Cancer Completed · 26 cited
  30. Phase 3 Hormone Suppression and Radiation Therapy for 6 Months With/Without Docetaxel for High Risk Prostate Cancer Completed · 25 cited
  31. Phase 3 Safety and Efficacy Study of Enzalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer Completed · 20 cited
  32. Phase 3 Hormone Therapy and Radiation Therapy or Hormone Therapy and Radiation Therapy Followed by Docetaxel and Prednisone in Treating Patients With Localized Prostate Cancer Completed · 20 cited
  33. Phase 3 PROvenge Treatment and Early Cancer Treatment Completed · 18 cited
  34. Phase 3 Efficacy and Safety of Leuprolide Acetate 22.5 mg Depot in Treatment of Prostate Cancer Completed · 17 cited
  35. Phase 4 3 Month Finasteride Challenge Test Can Significantly Improve the Performance of Screening for Prostate Cancer Completed · 13 cited
  36. Phase 4 A Study of ELIGARD® in Hormone-dependent Prostate Cancer Patients Completed · 9 cited
  37. Phase 3 Imaging Study to Investigate Safety and Diagnostic Performance of 18F rhPSMA 7.3 PET Ligand in Suspected Prostate Cancer Recurrence Completed · 6 cited
  38. Phase 3 Study of Diagnostic Performance of [18F]CTT1057 for PSMA-positive Tumors Detection Completed · 2 cited
  39. Phase 3 A Study of Nivolumab or Placebo in Combination With Docetaxel in Men With Advanced Castration-resistant Prostate Cancer Completed · 2 cited
  40. Phase 3 Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer Completed
  41. Phase 3 Study of Diagnostic Performance of [18F]CTT1057 in BCR Completed
  42. Phase 4 Global Performance Evaluation of the AMS CONTINUUM™ Device Completed
  43. Phase 4 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Completed
  44. Phase 4 A Study of Immediate 9 Months Adjuvant Hormone Therapy With Triptorelin 11.25 mg Versus Active Surveillance After Radical Prostatectomy in High Risk Prostate Cancer Patients. Completed

Showing the 50 most-cited and recently-updated of 669 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Prostate Cancer: what the trials found

In imaging diagnostics, flotufolastat (18F) PET demonstrated significantly lower urinary bladder radioactivity compared to piflufolastat (18F) PET (29.0 vs 10.9; p<0.001) 1.

Research into radiation delivery and imaging techniques showed that Research CBCT resulted in a significant reduction in Hounsfield Unit (HU) error compared to Standard CBCT in proton therapy patients (-128.8; p=0.001953), as well as a significantly lower ratio of artifact amplitude in photon therapy participants (1.489; p=0.0001) 16.

Recent results — preliminary, needs further review

  • Cabazitaxel, ARN-509, ELIGARD, and rhPSMA-7.3 (18F) injection were evaluated in Phase 2 or Phase 1 trials [2, 7, 13, 5].
  • Nivolumab resulted in a PSA50 response in 2 out of 8 participants 3.
  • Curcumin plus Piperine showed varying rates of patients without disease progression or death at 12 months (9; 6; 3) 4.
  • Hypofractionated radiation therapy was associated with specific counts of Grade 2 or greater GU and GI toxicity, while also providing data on SHIM scores and EPIC Sexual Scores for quality of life 6.
  • Androgen Deprivation Therapy (ADT) showed low rates of Grade 3 or greater GI/GU adverse events (4; 0) and recorded various IPSS scores 8.

For the clinician treating this condition

  • Flotufolastat (18F) PET shows a statistically significant reduction in urinary bladder radioactivity compared to piflufolastat, potentially improving imaging specificity 1.
  • Research CBCT demonstrates superior accuracy over Standard CBCT by reducing Hounsfield Unit errors and artifact amplitudes in both photon and proton therapy 16.

AI synthesis of 6 cited trials, updated Jun 22, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Prostate Cancer

Can dose intensification improve outcomes for intermediate- or high-risk prostate cancer?

Yes, early evidence suggests dose intensification to visible tumors may improve outcomes for intermediate- or high-risk prostate cancer, but ongoing trials will clarify safety and efficacy.

Full answer →
Is there more research on macrophage polarization for prostate cancer since 2015?

Yes, research on macrophage polarization in prostate cancer has grown significantly since 2015, with studies exploring its role in tumor progression and therapy resistance.

Full answer →
Can enzalutamide plus ADT improve survival for metastatic hormone-sensitive prostate cancer?

Yes, enzalutamide plus ADT significantly improves survival in metastatic hormone-sensitive prostate cancer, with a 34% reduction in risk of death and a 5-year survival rate of 66% versus 53% with ADT alone.

Full answer →

All Prostate Cancer Articles