N/A
N=51
Effect of Weight Loss on Myocardial Metabolism and Cardiac Relaxation in Obese Adults
Obesity
Bottom Line
View on ClinicalTrials.gov: NCT00572624 ↗Enrolled (actual)
51
Serious AEs
0.0%
Results posted
May 2017
Primary outcome: Primary: Total Myocardial Oxygen Consumption (MVO2) — 1064; 1202; 947; 835 µmol/min
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Diet (Behavioral); Gastric bypass surgery (Procedure)
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- Washington University School of Medicine
- Primary completion
- Jun 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Myocardial Oxygen Consumption (MVO2) |
1064; 1202; 947; 835 | — |
| PRIMARY Total Myocardial Fatty Acid (FA) Utilization |
148; 166; 144; 148 | — |
| PRIMARY Total Myocardial Fatty Acid (FA) Oxidation |
134; 141; 128; 127 | — |
| SECONDARY Left Ventricular (LV) Relaxation (E') |
14.0; 8.2; 14.1; 10.4 | — |
| SECONDARY Septal Ratio (E/E') |
5.9; 12.5; 6.1; 8.1 | — |
| SECONDARY Left Ventricular (LV) Mass |
186; 180; 186; 141 | — |
| SECONDARY Mean Heart Rate |
69; 72; 61; 65 | — |
| SECONDARY Mean Arterial Pressure |
89; 89; 89; 86 | — |
| SECONDARY Mean Body Mass Index |
39; 44; 36; 29 | — |
| SECONDARY Mean Total Serum Cholesterol and Triglycerides |
182; 167; 153; 136; 153; 168 | — |
| SECONDARY Mean Homeostasis Model Assessment of Insulin Resistance |
3.8; 5.5; 2.7; 0.9 | — |
Summary
Obesity adversely affects myocardial (muscular heart tissue) metabolism, efficiency, and diastolic function. The objective of this study was to determine if weight loss could improve obesity-related myocardial metabolism and efficiency and if these improvements were directly related to improved diastolic function.
Eligibility Criteria
Inclusion Criteria
- Body mass index (BMI) > 30 kg/m^2
- Sedentary lifestyle
Exclusion Criteria
- Body weight >159 kg
- Insulin-requiring diabetes
- Heart failure
- History of coronary artery disease
- Chest pain
- Untreated sleep apnea
- Being an active smoker
- Pregnant, lactating, or postmenopausal
Data sourced from ClinicalTrials.gov (NCT00572624). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.